KEGG   Homo sapiens (human): 7128
Entry
7128              CDS       T01001                                 
Symbol
TNFAIP3, A20, AIFBL1, AISBL, OTUD7C, TNFA1P2
Name
(RefSeq) TNF alpha induced protein 3
  KO
K11859  tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa04657  IL-17 signaling pathway
hsa04668  TNF signaling pathway
hsa05162  Measles
hsa05169  Epstein-Barr virus infection
Network
nt06169  Measles virus (MV)
nt06516  TNF signaling
nt06517  TLR signaling
  Element
N00692  MV P to TLR2/4-NFKB signaling pathway
N01546  Regulation of TNF-NFKB signaling pathway, OTULIN/TNFAIP3-mediated deubiquitination
Disease
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
H02592  Familial Behcet-like autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    7128 (TNFAIP3)
   04668 TNF signaling pathway
    7128 (TNFAIP3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    7128 (TNFAIP3)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    7128 (TNFAIP3)
   04657 IL-17 signaling pathway
    7128 (TNFAIP3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    7128 (TNFAIP3)
   05169 Epstein-Barr virus infection
    7128 (TNFAIP3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    7128 (TNFAIP3)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    7128 (TNFAIP3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     7128 (TNFAIP3)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C64
   7128 (TNFAIP3)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    7128 (TNFAIP3)
SSDB
Motif
Pfam: zf-A20 OTU
Other DBs
NCBI-GeneID: 7128
NCBI-ProteinID: NP_001257436
OMIM: 191163
HGNC: 11896
Ensembl: ENSG00000118503
UniProt: P21580
Structure
LinkDB
Position
6:137866349..137883312
AA seq 790 aa
MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQF
REIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDL
VLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTP
MARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPA
QECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKE
KLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENS
EQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPK
LNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRS
PGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCF
KRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGD
RTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGR
ECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARAS
CKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCN
ECFQFKQMYG
NT seq 2373 nt   +upstreamnt  +downstreamnt
atggctgaacaagtccttcctcaggctttgtatttgagcaatatgcggaaagctgtgaag
atacgggagagaactccagaagacatttttaaacctactaatgggatcattcatcatttt
aaaaccatgcaccgatacacactggaaatgttcagaacttgccagttttgtcctcagttt
cgggagatcatccacaaagccctcatcgacagaaacatccaggccaccctggaaagccag
aagaaactcaactggtgtcgagaagtccggaagcttgtggcgctgaaaacgaacggtgac
ggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttg
gtactgaggaaggcgctgttcagcacgctcaaggaaacagacacacgcaactttaaattc
cgctggcaactggagtctctcaaatctcaggaatttgttgaaacggggctttgctatgat
actcggaactggaatgatgaatgggacaatcttatcaaaatggcttccacagacacaccc
atggcccgaagtggacttcagtacaactcactggaagaaatacacatatttgtcctttgc
aacatcctcagaaggccaatcattgtcatttcagacaaaatgctaagaagtttggaatca
ggttccaatttcgcccctttgaaagtgggtggaatttacttgcctctccactggcctgcc
caggaatgctacagataccccattgttctcggctatgacagccatcattttgtacccttg
gtgaccctgaaggacagtgggcctgaaatccgagctgttccacttgttaacagagaccgg
ggaagatttgaagacttaaaagttcactttttgacagatcctgaaaatgagatgaaggag
aagctcttaaaagagtacttaatggtgatagaaatccccgtccaaggctgggaccatggc
acaactcatctcatcaatgccgcaaagttggatgaagctaacttaccaaaagaaatcaat
ctggtagatgattactttgaacttgttcagcatgagtacaagaaatggcaggaaaacagc
gagcaggggaggagagaggggcacgcccagaatcccatggaaccttccgtgccccagctt
tctctcatggatgtaaaatgtgaaacgcccaactgccccttcttcatgtctgtgaacacc
cagcctttatgccatgagtgctcagagaggcggcaaaagaatcaaaacaaactcccaaag
ctgaactccaagccgggccctgaggggctccctggcatggcgctcggggcctctcgggga
gaagcctatgagcccttggcgtggaaccctgaggagtccactggggggcctcattcggcc
ccaccgacagcacccagcccttttctgttcagtgagaccactgccatgaagtgcaggagc
cccggctgccccttcacactgaatgtgcagcacaacggattttgtgaacgttgccacaac
gcccggcaacttcacgccagccacgccccagaccacacaaggcacttggatcccgggaag
tgccaagcctgcctccaggatgttaccaggacatttaatgggatctgcagtacttgcttc
aaaaggactacagcagaggcctcctccagcctcagcaccagcctccctccttcctgtcac
cagcgttccaagtcagatccctcgcggctcgtccggagcccctccccgcattcttgccac
agagctggaaacgacgcccctgctggctgcctgtctcaagctgcacggactcctggggac
aggacggggacgagcaagtgcagaaaagccggctgcgtgtattttgggactccagaaaac
aagggcttttgcacactgtgtttcatcgagtacagagaaaacaaacattttgctgctgcc
tcagggaaagtcagtcccacagcgtccaggttccagaacaccattccgtgcctggggagg
gaatgcggcacccttggaagcaccatgtttgaaggatactgccagaagtgtttcattgaa
gctcagaatcagagatttcatgaggccaaaaggacagaagagcaactgagatcgagccag
cgcagagatgtgcctcgaaccacacaaagcacctcaaggcccaagtgcgcccgggcctcc
tgcaagaacatcctggcctgccgcagcgaggagctctgcatggagtgtcagcatcccaac
cagaggatgggccctggggcccaccggggtgagcctgcccccgaagacccccccaagcag
cgttgccgggcccccgcctgtgatcattttggcaatgccaagtgcaacggctactgcaac
gaatgctttcagttcaagcagatgtatggctaa

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