KEGG ORTHOLOGY: K11859

ORTHOLOGY: K11859

Entry

K11859                      KO

Symbol

TNFAIP3, A20, OTUD7C

Name

tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]

Pathway

map04064

NF-kappa B signaling pathway

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04668

TNF signaling pathway

map05162

Measles

map05169

Epstein-Barr virus infection

Disease

H02424

Primary central nervous system lymphoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

H02592

Familial Behcet-like autoinflammatory syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04668 TNF signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04657 IL-17 signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   05169 Epstein-Barr virus infection
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C64
   K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Ubiquitin system [BR:ko04121]
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3

Other DBs

GO:

0004843

Genes

HSA:	7128(TNFAIP3)

PTR:	472136(TNFAIP3)

PPS:	100994797(TNFAIP3)

GGO:	101149274(TNFAIP3)

PON:	100459145(TNFAIP3)

PPYG:

129038625(TNFAIP3)

NLE:	100600197(TNFAIP3)

HMH:	116472893(TNFAIP3)

SSYN:

129474201(TNFAIP3)

MCC:	704130(TNFAIP3)

MCF:	101867362(TNFAIP3)

MTHB:

126952579

MNI:	105465697(TNFAIP3)

CSAB:

103240296(TNFAIP3)

CATY:

105600386(TNFAIP3)

PANU:

100998710(TNFAIP3)

TGE:	112623017(TNFAIP3)

MLEU:

105538539(TNFAIP3)

RRO:	104675026(TNFAIP3)

RBB:	108518253(TNFAIP3)

TFN:	117097467(TNFAIP3)

PTEH:

111525526(TNFAIP3)

CANG:

105526163(TNFAIP3)

CJC:	100397002(TNFAIP3)

SBQ:	101052980(TNFAIP3)

CIMI:

108305702(TNFAIP3)

ANAN:

105732412(TNFAIP3)

CSYR:

103268872(TNFAIP3)

MMUR:

105862062(TNFAIP3)

LCAT:

123633309(TNFAIP3)

PCOQ:

105815343(TNFAIP3)

OGA:	100941032(TNFAIP3)

MMU:	21929(Tnfaip3)

MCAL:

110303143(Tnfaip3)

MPAH:

110338221(Tnfaip3)

RNO:	683206(Tnfaip3)

MCOC:

116097806(Tnfaip3)

ANU:	117701024(Tnfaip3)

MUN:	110566369(Tnfaip3)

CGE:	100771931(Tnfaip3)

MAUA:

101834866(Tnfaip3)

PROB:

127215037(Tnfaip3)

PLEU:

114686120(Tnfaip3)

MORG:

121450083(Tnfaip3)

MFOT:

126511950

AAMP:

119820781(Tnfaip3)

NGI:	103724893(Tnfaip3)

HGL:	101707330 101707725

CPOC:

100720503(Tnfaip3)

CCAN:

109697032(Tnfaip3)

DORD:

105993591(Tnfaip3)

DSP:	122125044(Tnfaip3)

PLOP:

125357333(Tnfaip3)

NCAR:

124989127

MMMA:

107155678(Tnfaip3)

OCU:

100350259

OPI:	101530617(TNFAIP3)

TUP:	102477224(TNFAIP3)

GVR:	103591258(TNFAIP3)

CFA:	484006(TNFAIP3)

CLUD:

112644182(TNFAIP3)

VVP:	112919472(TNFAIP3)

VLG:	121485796(TNFAIP3)

NPO:	129509287(TNFAIP3)

AML:	100474270(TNFAIP3)

UMR:	103663491(TNFAIP3)

UAH:	113259486(TNFAIP3)

UAR:	123803356(TNFAIP3)

ELK:

111147788

LLV:

125102704

MPUF:

101691448(TNFAIP3)

MNP:	132018190(TNFAIP3)

MLK:	131833753(TNFAIP3)

NVS:	122906225(TNFAIP3)

ORO:	101377530(TNFAIP3)

EJU:	114222770(TNFAIP3)

ZCA:	113926644(TNFAIP3)

MLX:	118000841(TNFAIP3)

NSU:	110583100(TNFAIP3)

LWW:	102750812(TNFAIP3)

FCA:	101083682(TNFAIP3)

PYU:	121013398(TNFAIP3)

PCOO:

112862294(TNFAIP3)

PBG:	122490018(TNFAIP3)

PVIV:

125166299(TNFAIP3)

LRUF:

124528541

PTG:	102958897(TNFAIP3)

PPAD:

109249867(TNFAIP3)

PUC:

125938952

AJU:

106982026

HHV:	120239375(TNFAIP3)

BTA:	508105(TNFAIP3)

BOM:	102266726(TNFAIP3)

BIU:	109563985(TNFAIP3)

BBUB:

102412133(TNFAIP3)

BBIS:

104991664(TNFAIP3)

CHX:	102182977(TNFAIP3)

OAS:	101113156(TNFAIP3)

BTAX:

128053331(TNFAIP3)

ODA:	120863082(TNFAIP3)

CCAD:

122434091(TNFAIP3)

MBEZ:

129560981(TNFAIP3)

SSC:	100622156(TNFAIP3)

CFR:	102523266(TNFAIP3)

CBAI:

105077436(TNFAIP3)

CDK:	105092086(TNFAIP3)

VPC:	102544179(TNFAIP3)

BACU:

103001161(TNFAIP3)

BMUS:

118905339(TNFAIP3)

LVE:	103081298(TNFAIP3)

OOR:	101275303(TNFAIP3)

DLE:	111166213(TNFAIP3)

PCAD:

102991611(TNFAIP3)

PSIU:

116763624(TNFAIP3)

NASI:

112409139(TNFAIP3)

ECB:	100073197(TNFAIP3)

EPZ:	103549048(TNFAIP3)

EAI:	106846056(TNFAIP3)

MYB:	102258379(TNFAIP3)

MYD:	102761078(TNFAIP3)

MMYO:

118659998(TNFAIP3)

MLF:	102439185(TNFAIP3)

PKL:	118705217(TNFAIP3)

EFUS:

103305243(TNFAIP3)

MNA:	107530982(TNFAIP3)

DRO:	112297385(TNFAIP3)

SHON:

118986669(TNFAIP3)

AJM:	119051859(TNFAIP3)

PDIC:

114495444(TNFAIP3) 114510145

PHAS:

123822086(TNFAIP3)

MMF:	118621121(TNFAIP3)

PPAM:

129067803(TNFAIP3)

HAI:	109385645(TNFAIP3)

RFQ:	117020725(TNFAIP3)

PALE:

102887009(TNFAIP3)

PGIG:

120603700 120615771(TNFAIP3)

PVP:	105289467(TNFAIP3)

RAY:	107505426(TNFAIP3)

MJV:	108399269(TNFAIP3)

TOD:	119251021 119252914(TNFAIP3)

SARA:

101548313(TNFAIP3)

SETR:

126029730(TNFAIP3)

LAV:	100670852(TNFAIP3)

TMU:

101345067

ETF:	101651870(TNFAIP3)

DNM:	101441990(TNFAIP3)

MDO:	100025842(TNFAIP3)

GAS:	123245639(TNFAIP3)

SHR:	100919524(TNFAIP3)

AFZ:

127562255

PCW:	110199059(TNFAIP3)

TVP:	118858399(TNFAIP3)

OAA:	100075332(TNFAIP3)

GGA:	421684(TNFAIP3)

PCOC:

116240637(TNFAIP3)

MGP:	100550484(TNFAIP3)

CJO:	107311676(TNFAIP3)

TPAI:

128076645(TNFAIP3)

LMUT:

125689287(TNFAIP3)

NMEL:

110396285(TNFAIP3)

APLA:

101796300(TNFAIP3)

ACYG:

106032519(TNFAIP3)

CATA:

118243941(TNFAIP3)

AFUL:

116488348(TNFAIP3)

TGU:	100227030(TNFAIP3)

LSR:	110483298(TNFAIP3)

SCAN:

103818470(TNFAIP3)

PMOA:

120501443(TNFAIP3)

OTC:	121346184(TNFAIP3)

PRUF:

121354999(TNFAIP3)

GFR:	102041044(TNFAIP3)

FAB:	101817397(TNFAIP3)

OMA:	130251644(TNFAIP3)

PHI:	102102986(TNFAIP3)

PMAJ:

107202524(TNFAIP3)

CCAE:

111945140(TNFAIP3)

CCW:	104689521(TNFAIP3)

CBRC:

103617651(TNFAIP3)

ETL:	114059512(TNFAIP3)

ZAB:	102062598(TNFAIP3)

ZLE:	135444891(TNFAIP3)

ACHL:

103810743(TNFAIP3)

SVG:	106854894(TNFAIP3)

MMEA:

130576339(TNFAIP3)

HRT:	120750956(TNFAIP3)

FPG:	101911730(TNFAIP3)

FCH:	102046472(TNFAIP3)

CLV:	102097352(TNFAIP3)

EGZ:	104131136(TNFAIP3)

NNI:	104008814(TNFAIP3)

PCRI:

104033162(TNFAIP3)

PLET:

104617651(TNFAIP3)

EHS:	104503452(TNFAIP3)

PCAO:

104053162(TNFAIP3)

ACUN:

113478855(TNFAIP3)

TALA:

104365454(TNFAIP3)

PADL:

103912709(TNFAIP3)

AFOR:

103900731(TNFAIP3)

ACHC:

115345133(TNFAIP3)

HALD:

104311314(TNFAIP3)

HLE:	104836210(TNFAIP3)

AGEN:

126038995

GCL:

127015038

CCRI:

104167197(TNFAIP3)

CSTI:

104554157(TNFAIP3)

CMAC:

104486787(TNFAIP3)

MUI:	104546684(TNFAIP3)

BREG:

104629590(TNFAIP3)

FGA:	104069123(TNFAIP3)

GSTE:

104250436(TNFAIP3)

LDI:	104340256(TNFAIP3)

MNB:	103780345(TNFAIP3)

OHA:	104327114(TNFAIP3)

NNT:	104406958(TNFAIP3)

SHAB:

115609894(TNFAIP3)

DPUB:

104300729(TNFAIP3)

PGUU:

104470818(TNFAIP3)

ACAR:

104528632(TNFAIP3)

CPEA:

104392356(TNFAIP3)

AVIT:

104272149(TNFAIP3)

CVF:	104284020(TNFAIP3)

RTD:	128907338(TNFAIP3)

CUCA:

104056240(TNFAIP3)

TEO:	104371558(TNFAIP3)

BRHI:

104494708(TNFAIP3)

AAM:	106497913(TNFAIP3)

AROW:

112971132(TNFAIP3)

NPD:	112954930(TNFAIP3)

TGT:	104571338(TNFAIP3)

DNE:	112996109(TNFAIP3)

SCAM:

104153150(TNFAIP3)

ASN:	102372488(TNFAIP3)

AMJ:	102558492(TNFAIP3)

CPOO:

109320187(TNFAIP3)

GGN:	109304738(TNFAIP3)

PSS:	102450291(TNFAIP3)

CMY:	102936943(TNFAIP3)

CCAY:

125634129(TNFAIP3)

DCC:	119853238(TNFAIP3)

CPIC:

101945596(TNFAIP3)

TST:	117874897(TNFAIP3)

CABI:

116818778(TNFAIP3)

MRV:	120401872(TNFAIP3)

ACS:	100564334(tnfaip3)

ASAO:

132760998(TNFAIP3)

PVT:	110071261(TNFAIP3)

SUND:

121918866(TNFAIP3)

PBI:	103068002(TNFAIP3)

PMUR:

107294501(TNFAIP3)

CTIG:

120298903(TNFAIP3)

TSR:	106547167(TNFAIP3)

PGUT:

117666303(TNFAIP3)

APRI:

131192099(TNFAIP3)

PTEX:

113439622(TNFAIP3)

NSS:	113411210(TNFAIP3)

VKO:	123020302(TNFAIP3)

PMUA:

114594180(TNFAIP3)

PRAF:

128410580(TNFAIP3)

ZVI:	118077770 118082066(TNFAIP3)

HCG:	128342105(TNFAIP3)

GJA:	107122065(TNFAIP3)

STOW:

125429036(TNFAIP3)

EMC:	129343091(TNFAIP3)

XLA:	446998(tnfaip3.S)

NPR:	108795154(TNFAIP3)

RTEM:

120937357(TNFAIP3)

BBUF:

120998529(TNFAIP3)

BGAR:

122934179(TNFAIP3)

MUO:	115465115 115466930

GSH:	117357980(TNFAIP3)

DRE:	564497(tnfaip3)

SRX:	107720364 107751155(tnfaip3)

SANH:

107681039 107699163

SGH:	107561980 107597710

CCAR:

109091353 109091354

CAUA:

113057381 113113085

CGIB:

127969644 128026548

PTET:

122335487(tnfaip3)

LROH:

127174790(tnfaip3)

OMC:	131552546(tnfaip3)

PPRM:

120492273(tnfaip3)

RKG:	130095213(tnfaip3)

MAMB:

125277485(tnfaip3)

CIDE:

127524917

MASI:

127412117 127413613

TROS:

130559463(tnfaip3)

TDW:	130431801(tnfaip3)

MANU:

129416016(tnfaip3)

IPU:

108263677

IFU:	128605277(tnfaip3)

PHYP:

113542100(tnfaip3)

SMEO:

124403391(tnfaip3)

TFD:	113655347(tnfaip3)

TVC:	132847010(tnfaip3)

TRN:	134315010(tnfaip3)

AMEX:

103035626(tnfaip3)

CMAO:

118810129(tnfaip3)

EEE:	113585834(tnfaip3)

CHAR:

105898157(tnfaip3)

TRU:	101062530(tnfaip3)

TFS:	130534217(tnfaip3)

TNG:	GSTEN00014358G001

LCO:	104928434(tnfaip3)

NCC:	104955588(tnfaip3)

TBEN:

117499655(tnfaip3)

CGOB:

115019818(tnfaip3)

PGEO:

117459543(tnfaip3)

GACU:

117560835(tnfaip3)

ELY:	117248491(tnfaip3)

EFO:	125903526(tnfaip3)

PLEP:

121954268(tnfaip3)

SLUC:

116056560(tnfaip3)

ECRA:

117959978(tnfaip3)

ESP:	116705091(tnfaip3)

PFLV:

114572289(tnfaip3)

GAT:	120820768(tnfaip3)

PPUG:

119214561(tnfaip3)

AFB:	129092203(tnfaip3)

CLUM:

117743681(tnfaip3)

PSWI:

130207390(tnfaip3)

MSAM:

119917056(tnfaip3)

SCHU:

122884521(tnfaip3)

CUD:	121510853(tnfaip3)

ALAT:

119033781(tnfaip3)

MZE:	101476138(tnfaip3)

ONL:	100692128(tnfaip3)

OAU:	116325737(tnfaip3)

OLA:	101160685(tnfaip3)

OML:	112161989(tnfaip3)

CSAI:

133463293(tnfaip3)

XMA:	102237440(tnfaip3)

XCO:	114138247(tnfaip3)

XHE:	116713474(tnfaip3)

PRET:

103476679(tnfaip3)

PFOR:

103137459(tnfaip3)

PLAI:

106957380(tnfaip3)

PMEI:

106927532(tnfaip3)

GAF:	122842081(tnfaip3)

PPRL:

129359794(tnfaip3)

CVG:	107099924(tnfaip3)

CTUL:

119790547(tnfaip3)

GMU:	124859347(tnfaip3)

NFU:	107375829(tnfaip3)

KMR:	108245439(tnfaip3)

ALIM:

106535065(tnfaip3)

NWH:	119418610(tnfaip3)

AOCE:

111582004(tnfaip3)

MCEP:

125019103(tnfaip3)

CSEM:

103386958(tnfaip3)

POV:	109634788(tnfaip3)

SSEN:

122781973(tnfaip3)

HHIP:

117775228(tnfaip3)

HSP:	118119057(tnfaip3)

PPLT:

128453615(tnfaip3)

SMAU:

118283644(tnfaip3)

LCF:

108897419

SDU:	111235218(tnfaip3)

SLAL:

111645308(tnfaip3)

XGL:	120796570(tnfaip3)

HCQ:	109510035(tnfaip3)

SSCV:

125979007

SBIA:

133509644(tnfaip3)

PEE:	133409468(tnfaip3)

PTAO:

133485515(tnfaip3)

BPEC:

110157241(tnfaip3)

MALB:

109959569(tnfaip3)

BSPL:

114841963(tnfaip3)

SJO:	128372943(tnfaip3)

SASA:

106589680(tnfaip3) 106610821

STRU:

115152841 115201493(tnfaip3)

OTW:	112224552 112234622

OMY:	100136337 110502983

OGO:	124038624 124040271

ONE:	115115916 115144332(tnfaip3)

OKI:	109870265(tnfaip3) 109875868

OKE:	118376197 118402833

SALP:

111968025(tnfaip3) 111978266

SNH:	120029473(tnfaip3) 120046845

CCLU:

121547633(tnfaip3) 121578069

ELS:	105021223(tnfaip3)

SFM:	108931280 108932919(tnfaip3)

PKI:	111837608(tnfaip3)

AANG:

118206810 118218217(tnfaip3) 118220328 118221581

LOC:	102692234(tnfaip3) 107077521

PSPA:

121303322 121316063 121317186(tnfaip3)

ARUT:

117402624 117410570(tnfaip3) 117413426 117413785

PSEX:

120516256(tnfaip3)

LCM:	102362242(TNFAIP3) 106703405

CMK:	103178317(tnfaip3) 103185665

RTP:	109916597(tnfaip3)

CPLA:

122547276(tnfaip3) 122564311

HOC:	132805532(tnfaip3) 132829959

LERI:

129697404(tnfaip3)

PMRN:

116955620(TNFAIP3)

LRJ:

133357132

BFO:	118422293 118422444 118422666 118423520 118423658

BBEL:

109472437 109488011 109488038 109488039

SPU:

APLC:

ARUN:

SKO:

HRO:	HELRODRAFT_163398

PVUL:

PCAN:

BGT:

GAE:

HRF:	124113622 124147847

HRJ:	124261918 124282613

CRG:

105347244

CANU:

128183348

CVN:	111104432 111134417

OED:

MYI:

PMAX:

MMER:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124441119 124441293 124441526 124441529 124441531 124442386 124443398

HMG:

105848063

AQU:

105316699

» show all

Reference

PMID:15258597

Authors

Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM

Title

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

Journal

Nature 430:694-9 (2004)
DOI:10.1038/nature02794

Reference

PMID:2118515

Authors

Opipari AW Jr, Boguski MS, Dixit VM

Title

The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.

Journal

J Biol Chem 265:14705-8 (1990)

Sequence

[hsa:7128]

LinkDB

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