K11859                      KO                                     
tumor necrosis factor, alpha-induced protein 3 [EC:]
map04064  NF-kappa B signaling pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04668  TNF signaling pathway
map05162  Measles
map05169  Epstein-Barr virus infection
H02424  Primary central nervous system lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
H02592  Familial Behcet-like autoinflammatory syndrome
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04668 TNF signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   04657 IL-17 signaling pathway
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
   05169 Epstein-Barr virus infection
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases  ubiquitinyl hydrolase 1
     K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C64
   K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
    K11859  TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3
Other DBs
GO: 0004843
HSA: 7128(TNFAIP3)
PTR: 472136(TNFAIP3)
PPS: 100994797(TNFAIP3)
GGO: 101149274(TNFAIP3)
PON: 100459145(TNFAIP3)
NLE: 100600197(TNFAIP3)
HMH: 116472893(TNFAIP3)
MCC: 704130(TNFAIP3)
MCF: 101867362(TNFAIP3)
MTHB: 126952579
MNI: 105465697(TNFAIP3)
CSAB: 103240296(TNFAIP3)
CATY: 105600386(TNFAIP3)
PANU: 100998710(TNFAIP3)
TGE: 112623017(TNFAIP3)
MLEU: 105538539(TNFAIP3)
RRO: 104675026(TNFAIP3)
RBB: 108518253(TNFAIP3)
TFN: 117097467(TNFAIP3)
PTEH: 111525526(TNFAIP3)
CANG: 105526163(TNFAIP3)
CJC: 100397002(TNFAIP3)
SBQ: 101052980(TNFAIP3)
CIMI: 108305702(TNFAIP3)
CSYR: 103268872(TNFAIP3)
MMUR: 105862062(TNFAIP3)
LCAT: 123633309(TNFAIP3)
PCOQ: 105815343(TNFAIP3)
OGA: 100941032(TNFAIP3)
MMU: 21929(Tnfaip3)
MCAL: 110303143(Tnfaip3)
MPAH: 110338221(Tnfaip3)
RNO: 683206(Tnfaip3)
MCOC: 116097806(Tnfaip3)
ANU: 117701024(Tnfaip3)
MUN: 110566369(Tnfaip3)
CGE: 100771931(Tnfaip3)
MAUA: 101834866(Tnfaip3)
PROB: 127215037(Tnfaip3)
PLEU: 114686120(Tnfaip3)
MORG: 121450083(Tnfaip3)
MFOT: 126511950
AAMP: 119820781(Tnfaip3)
NGI: 103724893(Tnfaip3)
CPOC: 100720503(Tnfaip3)
CCAN: 109697032(Tnfaip3)
DORD: 105993591(Tnfaip3)
DSP: 122125044(Tnfaip3)
PLOP: 125357333(Tnfaip3)
NCAR: 124989127
MMMA: 107155678(Tnfaip3)
OCU: 100350259
OPI: 101530617(TNFAIP3)
TUP: 102477224(TNFAIP3)
GVR: 103591258(TNFAIP3)
CFA: 484006(TNFAIP3)
CLUD: 112644182(TNFAIP3)
VVP: 112919472(TNFAIP3)
VLG: 121485796(TNFAIP3)
NPO: 129509287(TNFAIP3)
AML: 100474270(TNFAIP3)
UMR: 103663491(TNFAIP3)
UAH: 113259486(TNFAIP3)
UAR: 123803356(TNFAIP3)
ELK: 111147788
LLV: 125102704
MPUF: 101691448(TNFAIP3)
MNP: 132018190(TNFAIP3)
MLK: 131833753(TNFAIP3)
NVS: 122906225(TNFAIP3)
ORO: 101377530(TNFAIP3)
EJU: 114222770(TNFAIP3)
ZCA: 113926644(TNFAIP3)
MLX: 118000841(TNFAIP3)
NSU: 110583100(TNFAIP3)
LWW: 102750812(TNFAIP3)
FCA: 101083682(TNFAIP3)
PYU: 121013398(TNFAIP3)
PCOO: 112862294(TNFAIP3)
PBG: 122490018(TNFAIP3)
LRUF: 124528541
PTG: 102958897(TNFAIP3)
PPAD: 109249867(TNFAIP3)
PUC: 125938952
AJU: 106982026
HHV: 120239375(TNFAIP3)
BTA: 508105(TNFAIP3)
BOM: 102266726(TNFAIP3)
BIU: 109563985(TNFAIP3)
BBUB: 102412133(TNFAIP3)
BBIS: 104991664(TNFAIP3)
CHX: 102182977(TNFAIP3)
OAS: 101113156(TNFAIP3)
BTAX: 128053331(TNFAIP3)
ODA: 120863082(TNFAIP3)
CCAD: 122434091(TNFAIP3)
MBEZ: 129560981(TNFAIP3)
SSC: 100622156(TNFAIP3)
CFR: 102523266(TNFAIP3)
CBAI: 105077436(TNFAIP3)
CDK: 105092086(TNFAIP3)
VPC: 102544179(TNFAIP3)
BACU: 103001161(TNFAIP3)
LVE: 103081298(TNFAIP3)
OOR: 101275303(TNFAIP3)
DLE: 111166213(TNFAIP3)
PCAD: 102991611(TNFAIP3)
PSIU: 116763624(TNFAIP3)
NASI: 112409139(TNFAIP3)
ECB: 100073197(TNFAIP3)
EPZ: 103549048(TNFAIP3)
EAI: 106846056(TNFAIP3)
MYB: 102258379(TNFAIP3)
MYD: 102761078(TNFAIP3)
MMYO: 118659998(TNFAIP3)
MLF: 102439185(TNFAIP3)
PKL: 118705217(TNFAIP3)
EFUS: 103305243(TNFAIP3)
MNA: 107530982(TNFAIP3)
DRO: 112297385(TNFAIP3)
SHON: 118986669(TNFAIP3)
AJM: 119051859(TNFAIP3)
PDIC: 114495444(TNFAIP3) 114510145
PHAS: 123822086(TNFAIP3)
MMF: 118621121(TNFAIP3)
PPAM: 129067803(TNFAIP3)
HAI: 109385645(TNFAIP3)
RFQ: 117020725(TNFAIP3)
PALE: 102887009(TNFAIP3)
PGIG: 120603700 120615771(TNFAIP3)
PVP: 105289467(TNFAIP3)
RAY: 107505426(TNFAIP3)
MJV: 108399269(TNFAIP3)
TOD: 119251021 119252914(TNFAIP3)
SARA: 101548313(TNFAIP3)
LAV: 100670852(TNFAIP3)
TMU: 101345067
ETF: 101651870(TNFAIP3)
DNM: 101441990(TNFAIP3)
MDO: 100025842(TNFAIP3)
GAS: 123245639(TNFAIP3)
SHR: 100919524(TNFAIP3)
AFZ: 127562255
PCW: 110199059(TNFAIP3)
OAA: 100075332(TNFAIP3)
GGA: 421684(TNFAIP3)
PCOC: 116240637(TNFAIP3)
MGP: 100550484(TNFAIP3)
CJO: 107311676(TNFAIP3)
TPAI: 128076645(TNFAIP3)
LMUT: 125689287(TNFAIP3)
NMEL: 110396285(TNFAIP3)
APLA: 101796300(TNFAIP3)
ACYG: 106032519(TNFAIP3)
CATA: 118243941(TNFAIP3)
AFUL: 116488348(TNFAIP3)
TGU: 100227030(TNFAIP3)
LSR: 110483298(TNFAIP3)
SCAN: 103818470(TNFAIP3)
PMOA: 120501443(TNFAIP3)
OTC: 121346184(TNFAIP3)
PRUF: 121354999(TNFAIP3)
GFR: 102041044(TNFAIP3)
FAB: 101817397(TNFAIP3)
OMA: 130251644(TNFAIP3)
PHI: 102102986(TNFAIP3)
PMAJ: 107202524(TNFAIP3)
CCAE: 111945140(TNFAIP3)
CCW: 104689521(TNFAIP3)
CBRC: 103617651(TNFAIP3)
ETL: 114059512(TNFAIP3)
ZAB: 102062598(TNFAIP3)
ACHL: 103810743(TNFAIP3)
SVG: 106854894(TNFAIP3)
MMEA: 130576339(TNFAIP3)
HRT: 120750956(TNFAIP3)
FPG: 101911730(TNFAIP3)
FCH: 102046472(TNFAIP3)
CLV: 102097352(TNFAIP3)
EGZ: 104131136(TNFAIP3)
NNI: 104008814(TNFAIP3)
PCRI: 104033162(TNFAIP3)
PLET: 104617651(TNFAIP3)
EHS: 104503452(TNFAIP3)
PCAO: 104053162(TNFAIP3)
ACUN: 113478855(TNFAIP3)
TALA: 104365454(TNFAIP3)
PADL: 103912709(TNFAIP3)
AFOR: 103900731(TNFAIP3)
ACHC: 115345133(TNFAIP3)
HALD: 104311314(TNFAIP3)
HLE: 104836210(TNFAIP3)
AGEN: 126038995
GCL: 127015038
CCRI: 104167197(TNFAIP3)
CSTI: 104554157(TNFAIP3)
CMAC: 104486787(TNFAIP3)
MUI: 104546684(TNFAIP3)
BREG: 104629590(TNFAIP3)
FGA: 104069123(TNFAIP3)
GSTE: 104250436(TNFAIP3)
LDI: 104340256(TNFAIP3)
MNB: 103780345(TNFAIP3)
OHA: 104327114(TNFAIP3)
NNT: 104406958(TNFAIP3)
SHAB: 115609894(TNFAIP3)
DPUB: 104300729(TNFAIP3)
PGUU: 104470818(TNFAIP3)
ACAR: 104528632(TNFAIP3)
CPEA: 104392356(TNFAIP3)
AVIT: 104272149(TNFAIP3)
CVF: 104284020(TNFAIP3)
RTD: 128907338(TNFAIP3)
CUCA: 104056240(TNFAIP3)
TEO: 104371558(TNFAIP3)
BRHI: 104494708(TNFAIP3)
AAM: 106497913(TNFAIP3)
AROW: 112971132(TNFAIP3)
NPD: 112954930(TNFAIP3)
TGT: 104571338(TNFAIP3)
DNE: 112996109(TNFAIP3)
SCAM: 104153150(TNFAIP3)
ASN: 102372488(TNFAIP3)
AMJ: 102558492(TNFAIP3)
CPOO: 109320187(TNFAIP3)
GGN: 109304738(TNFAIP3)
PSS: 102450291(TNFAIP3)
CMY: 102936943(TNFAIP3)
CCAY: 125634129(TNFAIP3)
DCC: 119853238(TNFAIP3)
CPIC: 101945596(TNFAIP3)
TST: 117874897(TNFAIP3)
CABI: 116818778(TNFAIP3)
MRV: 120401872(TNFAIP3)
ACS: 100564334(tnfaip3)
ASAO: 132760998(TNFAIP3)
PVT: 110071261(TNFAIP3)
SUND: 121918866(TNFAIP3)
PBI: 103068002(TNFAIP3)
PMUR: 107294501(TNFAIP3)
CTIG: 120298903(TNFAIP3)
TSR: 106547167(TNFAIP3)
PGUT: 117666303(TNFAIP3)
APRI: 131192099(TNFAIP3)
PTEX: 113439622(TNFAIP3)
NSS: 113411210(TNFAIP3)
VKO: 123020302(TNFAIP3)
PMUA: 114594180(TNFAIP3)
PRAF: 128410580(TNFAIP3)
ZVI: 118077770 118082066(TNFAIP3)
HCG: 128342105(TNFAIP3)
GJA: 107122065(TNFAIP3)
STOW: 125429036(TNFAIP3)
EMC: 129343091(TNFAIP3)
XLA: 446998(tnfaip3.S)
NPR: 108795154(TNFAIP3)
RTEM: 120937357(TNFAIP3)
BBUF: 120998529(TNFAIP3)
BGAR: 122934179(TNFAIP3)
GSH: 117357980(TNFAIP3)
DRE: 564497(tnfaip3)
SRX: 107720364 107751155(tnfaip3)
PTET: 122335487(tnfaip3)
LROH: 127174790(tnfaip3)
OMC: 131552546(tnfaip3)
PPRM: 120492273(tnfaip3)
RKG: 130095213(tnfaip3)
MAMB: 125277485(tnfaip3)
CIDE: 127524917
TROS: 130559463(tnfaip3)
TDW: 130431801(tnfaip3)
MANU: 129416016(tnfaip3)
IPU: 108263677
IFU: 128605277(tnfaip3)
PHYP: 113542100(tnfaip3)
SMEO: 124403391(tnfaip3)
TFD: 113655347(tnfaip3)
TVC: 132847010(tnfaip3)
AMEX: 103035626(tnfaip3)
CMAO: 118810129(tnfaip3)
EEE: 113585834(tnfaip3)
CHAR: 105898157(tnfaip3)
TRU: 101062530(tnfaip3)
TFS: 130534217(tnfaip3)
LCO: 104928434(tnfaip3)
NCC: 104955588(tnfaip3)
TBEN: 117499655(tnfaip3)
CGOB: 115019818(tnfaip3)
PGEO: 117459543(tnfaip3)
GACU: 117560835(tnfaip3)
ELY: 117248491(tnfaip3)
EFO: 125903526(tnfaip3)
PLEP: 121954268(tnfaip3)
SLUC: 116056560(tnfaip3)
ECRA: 117959978(tnfaip3)
ESP: 116705091(tnfaip3)
PFLV: 114572289(tnfaip3)
GAT: 120820768(tnfaip3)
PPUG: 119214561(tnfaip3)
AFB: 129092203(tnfaip3)
CLUM: 117743681(tnfaip3)
PSWI: 130207390(tnfaip3)
MSAM: 119917056(tnfaip3)
SCHU: 122884521(tnfaip3)
CUD: 121510853(tnfaip3)
ALAT: 119033781(tnfaip3)
MZE: 101476138(tnfaip3)
ONL: 100692128(tnfaip3)
OAU: 116325737(tnfaip3)
OLA: 101160685(tnfaip3)
OML: 112161989(tnfaip3)
CSAI: 133463293(tnfaip3)
XMA: 102237440(tnfaip3)
XCO: 114138247(tnfaip3)
XHE: 116713474(tnfaip3)
PRET: 103476679(tnfaip3)
PFOR: 103137459(tnfaip3)
PLAI: 106957380(tnfaip3)
PMEI: 106927532(tnfaip3)
GAF: 122842081(tnfaip3)
PPRL: 129359794(tnfaip3)
CVG: 107099924(tnfaip3)
CTUL: 119790547(tnfaip3)
GMU: 124859347(tnfaip3)
NFU: 107375829(tnfaip3)
KMR: 108245439(tnfaip3)
ALIM: 106535065(tnfaip3)
NWH: 119418610(tnfaip3)
AOCE: 111582004(tnfaip3)
MCEP: 125019103(tnfaip3)
CSEM: 103386958(tnfaip3)
POV: 109634788(tnfaip3)
SSEN: 122781973(tnfaip3)
HHIP: 117775228(tnfaip3)
HSP: 118119057(tnfaip3)
SMAU: 118283644(tnfaip3)
LCF: 108897419
SDU: 111235218(tnfaip3)
SLAL: 111645308(tnfaip3)
XGL: 120796570(tnfaip3)
HCQ: 109510035(tnfaip3)
SSCV: 125979007
SBIA: 133509644(tnfaip3)
PEE: 133409468(tnfaip3)
PTAO: 133485515(tnfaip3)
BPEC: 110157241(tnfaip3)
MALB: 109959569(tnfaip3)
BSPL: 114841963(tnfaip3)
SJO: 128372943(tnfaip3)
SASA: 106589680(tnfaip3) 106610821
STRU: 115152841 115201493(tnfaip3)
ONE: 115115916 115144332(tnfaip3)
OKI: 109870265(tnfaip3) 109875868
SALP: 111968025(tnfaip3) 111978266
SNH: 120029473(tnfaip3) 120046845
CCLU: 121547633(tnfaip3) 121578069
ELS: 105021223(tnfaip3)
SFM: 108931280 108932919(tnfaip3)
PKI: 111837608(tnfaip3)
LOC: 102692234(tnfaip3) 107077521
PSPA: 121303322 121316063 121317186(tnfaip3)
PSEX: 120516256(tnfaip3)
LCM: 102362242(TNFAIP3) 106703405
CMK: 103178317(tnfaip3) 103185665
RTP: 109916597(tnfaip3)
CPLA: 122547276(tnfaip3) 122564311
HOC: 132805532(tnfaip3) 132829959
LERI: 129697404(tnfaip3)
PMRN: 116955620(TNFAIP3)
LRJ: 133357132
SPU: 590500
APLC: 110974467
SKO: 100369415
PVUL: 126810920
PCAN: 112567026
BGT: 106078457
GAE: 121372539
CRG: 105347244
CANU: 128183348
OED: 125674859
MYI: 110463768
PMAX: 117327794
MMER: 123553032
LAK: 106165950
NVE: 5510450
EPA: 110235961
ATEN: 116303600
ADF: 107344228
AMIL: 114975192
PDAM: 113664510
SPIS: 111325763
DGT: 114537034
HMG: 105848063
AQU: 105316699
 » show all
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Nature 430:694-9 (2004)
Opipari AW Jr, Boguski MS, Dixit VM
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
J Biol Chem 265:14705-8 (1990)

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