KEGG T01001: 7139

Homo sapiens (human): 7139

Entry

7139              CDS       T01001

Symbol

TNNT2, CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT

Name

(RefSeq) troponin T2, cardiac type

K12045

troponin T, cardiac muscle

Organism

hsa Homo sapiens (human)

Pathway

hsa04260

Cardiac muscle contraction

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04814

Motor proteins

hsa04820

Cytoskeleton in muscle cells

hsa05410

Hypertrophic cardiomyopathy

hsa05414

Dilated cardiomyopathy

Network

nt06539 Cytoskeleton in muscle cells

Element

N01818

Actin thin filament, muscle contraction

Disease

H00292

Hypertrophic cardiomyopathy

H00294

Dilated cardiomyopathy

H01216

Left ventricular noncompaction

H01219

Restrictive cardiomyopathy

Drug target

Nelutroctiv:

D12804

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    7139 (TNNT2)
   04820 Cytoskeleton in muscle cells
    7139 (TNNT2)
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    7139 (TNNT2)
   04261 Adrenergic signaling in cardiomyocytes
    7139 (TNNT2)
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    7139 (TNNT2)
   05414 Dilated cardiomyopathy
    7139 (TNNT2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7139 (TNNT2)
Cytoskeleton proteins [BR:hsa04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Troponins
     7139 (TNNT2)

SSDB

Motif

Pfam:

Troponin

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

1:complement(201359014..201377680)

AA seq 298 aa
MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE
EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF
ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED
EARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR
EKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK

NT seq 897 nt +upstreamnt +downstreamnt
atgtctgacatagaagaggtggtggaagagtacgaggaggaggagcaggaagaagcagct
gttgaagaagaggaggactggagagaggacgaagacgagcaggaggaggcagcggaagag
gatgctgaagcagaggctgagaccgaggagaccagggcagaagaagatgaagaagaagag
gaagcaaaggaggctgaagatggcccaatggaggagtccaaaccaaagcccaggtcgttc
atgcccaacttggtgcctcccaagatccccgatggagagagagtggactttgatgacatc
caccggaagcgcatggagaaggacctgaatgagttgcaggcgctgatcgaggctcacttt
gagaacaggaagaaagaggaggaggagctcgtttctctcaaagacaggatcgagagacgt
cgggcagagcgggccgagcagcagcgcatccggaatgagcgggagaaggagcggcagaac
cgcctggctgaagagagggctcgacgagaggaggaggagaacaggaggaaggctgaggat
gaggcccggaagaagaaggctttgtccaacatgatgcattttgggggttacatccagaag
caggcccagacagagcggaaaagtgggaagaggcagactgagcgggaaaagaagaagaag
attctggctgagaggaggaaggtgctggccattgaccacctgaatgaagatcagctgagg
gagaaggccaaggagctgtggcagagcatctataacttggaggcagagaagttcgacctg
caggagaagttcaagcagcagaaatatgagatcaatgttctccgaaacaggatcaacgat
aaccagaaagtctccaagacccgcgggaaggctaaagtcaccgggcgctggaaatag

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