KEGG   Homo sapiens (human): 728
Entry
728               CDS       T01001                                 
Symbol
C5AR1, C5A, C5AR, C5R1, CD88
Name
(RefSeq) complement C5a receptor 1
  KO
K04010  C5a anaphylatoxin chemotactic receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04613  Neutrophil extracellular trap formation
hsa04936  Alcoholic liver disease
hsa05150  Staphylococcus aureus infection
hsa05171  Coronavirus disease - COVID-19
Drug target
Avacopan: D11093<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    728 (C5AR1)
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    728 (C5AR1)
   04613 Neutrophil extracellular trap formation
    728 (C5AR1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    728 (C5AR1)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    728 (C5AR1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    728 (C5AR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    728 (C5AR1)
   04090 CD molecules [BR:hsa04090]
    728 (C5AR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Peptide
   Anaphylatoxin
    728 (C5AR1)
CD molecules [BR:hsa04090]
 Proteins
  728 (C5AR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx 7TM_GPCR_Srw
Other DBs
NCBI-GeneID: 728
NCBI-ProteinID: NP_001727
OMIM: 113995
HGNC: 1338
Ensembl: ENSG00000197405
UniProt: P21730
Structure
LinkDB
Position
19:47307477..47322066
AA seq 350 aa
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
NT seq 1053 nt   +upstreamnt  +downstreamnt
atggactccttcaattataccacccctgattatgggcactatgatgacaaggataccctg
gacctcaacacccctgtggataaaacttctaacacgctgcgtgttccagacatcctggcc
ttggtcatctttgcagtcgtcttcctggtgggagtgctgggcaatgccctggtggtctgg
gtgacggcattcgaggccaagcggaccatcaatgccatctggttcctcaacttggcggta
gccgacttcctctcctgcctggcgctgcccatcttgttcacgtccattgtacagcatcac
cactggccctttggcggggccgcctgcagcatcctgccctccctcatcctgctcaacatg
tacgccagcatcctgctcctggccaccatcagcgccgaccgctttctgctggtgtttaaa
cccatctggtgccagaacttccgaggggctggcttggcctggatcgcctgtgccgtggct
tggggtttagccctgctgctgaccataccctccttcctgtaccgggtggtccgggaggag
tactttccaccaaaggtgttgtgtggcgtggactacagccacgacaaacggcgggagcga
gccgtggccatcgtccggctggtcctgggcttcctgtggcctctactcacgctcacgatt
tgttacactttcatcctgctccggacgtggagccgcagggccacgcggtccaccaagaca
ctcaaggtggtggtggcagtggtggccagtttctttatcttctggttgccctaccaggtg
acggggataatgatgtccttcctggagccatcgtcacccaccttcctgctgctgaagaag
ctggactccctgtgtgtctcctttgcctacatcaactgctgcatcaaccccatcatctac
gtggtggccggccagggcttccagggccgactgcggaaatccctccccagcctcctccgg
aacgtgttgactgaagagtccgtggttagggagagcaagtcattcacgcgctccacagtg
gacactatggcccagaagacccaggcagtgtag

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