Homo sapiens (human): 7399 Help Entry 7399              CDS       T01001                                  Symbol USH2A, RP39, US2, USH2, dJ1111A8.1 Name (RefSeq) usherin isoform B precursor   KO K19636   usherin Organism hsa  Homo sapiens (human) Disease H00527   Retinitis pigmentosa H00779   Usher syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    03037 Cilium and associated proteins [BR:hsa03037]     7399 (USH2A) Cilium and associated proteins [BR:hsa03037]  Primary cilia and associated proteins   USH complex and associated proteins    7399 (USH2A) SSDB OrthologParalogGFIT Motif Pfam:  fn3 EGF_laminin Pur_ac_phosph_N FN3_DSCAM-DSCAML_C Laminin_G_2 Laminin_G_1 Laminin_N Fn3_VIN3 Fn3_ROS1 Laminin_G_3 EGF_LMN_ATRN Ig_PTPRO_6th Motif Other DBs NCBI-GeneID:  7399 NCBI-ProteinID:  NP_996816 OMIM:  608400 HGNC:  12601 Ensembl:  ENSP00000305941.3 UniProt:  O75445 LinkDB All DBs Position 1:complement(215622891..216423448) Genome browser AA seq 5202 aa AA seqDB search MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLRWFPPEELNGPSPIY QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFA ASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQ ITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK NYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEI SFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKW NKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG GCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGG LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGC TESSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSG SEENYIVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIH IQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGA CTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDG ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQ GSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLID GLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPAR NNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH SSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG NVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSV IISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH MPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTV PQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIY SGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTA IDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVF NGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRG ITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESIC GHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIV SNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCE TELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWN SYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNG IERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTA CTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRN GNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQY EIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY FIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENG RALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAW GNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQ APPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPT VQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTM EALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNG DIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRA PTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTAS EWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTT LYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMG LADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDN SLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL NT seq 15609 nt NT seq  +upstreamnt  +downstreamnt atgaattgcccagttctttcattgggctctggcttcttgtttcaggtcattgaaatgttg atctttgcctattttgcttcaatatccttgactgagtcacgaggtcttttcccaaggctg gagaacgtgggagctttcaagaaagtttccatcgtgccaacccaagcagtatgtggactc ccagaccgaagcactttttgtcacagctctgctgctgctgaaagtattcagttctgtacc cagcggttttgtattcaggattgcccatacagatcttcacaccctacctacactgccctt ttctcagcaggcctcagtagctgcatcacaccagacaagaatgatctgcatcctaacgcc catagcaattctgcaagttttatttttggaaatcacaagagctgcttttcttctcctcct tctccaaagctgatggcatcatttaccttagctgtatggctgaaacctgagcaacaaggt gtaatgtgtgttatagaaaagacagtagatgggcagattgtgttcaaacttacaatatct gagaaagagaccatgttttattatcgcacagtaaatggtttgcaacctccaataaaagta atgacactggggagaattcttgtgaagaaatggattcatcttagtgtgcaggtgcatcag acaaaaatcagcttctttatcaatggcgtggagaaggatcatacacctttcaatgcaaga actctaagtggttcaattacagattttgcatctggtactgtgcaaataggacagagttta aatggtttagagcagtttgtcggaagaatgcaagattttcgattataccaagtggcactt acaaacagagagattctggaagtcttctctggagatcttctcagattgcatgcccaatca cattgccgttgccctggcagccacccgcgggtccaccctttggcacagcggtactgcatt cctaatgatgcaggagacacagctgataatagagtgtcacggttgaatcctgaagcccat cctctctcttttgtcaatgataatgatgttggtacttcatgggtttcaaatgtgtttaca aacattacacagcttaatcaaggagtgactatttcagttgatttggaaaatggacagtat caggtgttttatattatcattcagttctttagtccacaaccaacggaaataaggattcaa aggaagaaggaaaatagtttagattgggaggactggcaatattttgccaggaattgtggt gcttttggaatgaaaaacaatggagatttggaaaaacctgattctgtcaactgtcttcag ctttccaattttactccatattcccgtggcaatgtcacatttagcatcctgacacctgga ccaaattatcgtcctggatacaataacttctataataccccatctcttcaagagttcgta aaagccacgcaaataaggtttcattttcatgggcagtactatacaactgagactgctgtt aacctcagacacagatattatgcagtggacgaaatcaccattagtgggagatgtcagtgc catggtcatgccgataactgcgacacaacaagccagccatatagatgcctctgctcccag gagagcttcactgaaggacttcattgtgatcgctgcttgcctctttataatgacaagcct ttccgccaaggtgatcaagtttacgctttcaattgtaaaccttgtcaatgcaacagccat tccaaaagctgccattacaacatctctgtagacccatttccttttgagcacttcagaggg ggaggaggagtttgtgatgattgtgagcataacactacaggaaggaactgtgagctgtgc aaggattactttttccgacaagttggtgcagatccttcggccatagatgtttgcaaaccc tgtgactgtgatacagttggcactagaaatggtagcattctttgtgatcagattggagga cagtgtaattgtaagagacacgtgtctggcaggcagtgcaatcagtgccagaatggattc tacaatctacaagagttggatcctgatggctgcagtccctgtaactgcaatacctctggg acagtggatggagatattacctgtcaccaaaattcaggccagtgcaagtgcaaagcaaac gttattgggcttaggtgtgatcattgcaattttggatttaaatttctccgaagctttaat gatgttggatgtgagccctgccagtgtaacctccatggctcagtgaacaaattctgcaat cctcactctgggcagtgtgagtgcaaaaaagaagccaaaggacttcagtgtgacacctgc agagaaaacttttatgggttagatgtcaccaattgtaaggcctgtgactgtgacacagct ggatccctccctgggactgtctgtaatgctaagacagggcagtgcatctgcaagcccaat gttgaagggagacagtgcaataaatgtttggagggaaacttctacctacggcaaaataat tctttcctctgtctgccttgcaactgtgataagactgggacaataaatggctctctgctg tgtaacaaatcaacaggacaatgtccttgcaaattaggggtaacaggtcttcgctgtaat cagtgtgagcctcacaggtacaatttgaccattgacaattttcaacactgccagatgtgt gagtgtgattccttggggacattacctgggaccatttgtgacccaatcagtggccagtgc ctgtgtgtgcctaatcgtcaaggaagaaggtgtaatcagtgtcaaccaggtttttatatt tctccaggcaatgccactggctgcctgccatgctcatgccatacaactggtgcagttaat cacatctgtaatagcctgactggtcagtgtgtttgccaagatgcttccattgctgggcaa cgttgtgaccaatgcaaagaccattactttggatttgatcctcagactggaagatgtcag ccttgtaattgtcatctctcaggagccttgaatgaaacctgtcacttggtcacaggccag tgtttctgtaaacaatttgtcactggctcaaagtgtgatgcttgtgttcccagtgcaagc cacttggatgtcaacaatctattgggttgcagcaaaactccattccagcaacctccgccc agaggacaagttcaaagttcttctgctatcaatctctcctggagtccacctgattctcca aatgcccactggcttacttacagtttactcagggatggttttgaaatctacacaacagag gatcaatacccatacagtattcaatacttcttagacacagacctgttaccatataccaaa tattcctattacattgagaccaccaatgtgcatggttcaacaaggagtgtagctgtcact tacaagacaaaaccaggggtcccagagggaaacttgactttaagttatatcattcctatt ggctcagactctgtgacacttacctggacaacactctcaaatcaatctggtcccatagag aaatatattttgtcctgtgcccctttggctggtggtcagccatgtgtttcctacgaaggt catgaaacctcagctaccatctggaatctggttccatttgccaagtacgatttttctgta caggcgtgtactagcgggggctgtttacacagcttgcccattacagtgaccacagcccag gcccctccccaaagactaagtccacctaagatgcagaaaatcagttctacagaacttcat gtagaatggtctccaccagcggaactaaatggaataattataagatatgaactatacatg agaagactgagatctactaaagaaaccacatctgaggaaagtcgagtttttcagagcagt ggttggctcagtcctcattcatttgtagaatcggccaatgaaaatgcattaaaacctcct caaacaatgacaaccatcactggcttggagccatacaccaagtatgagttcagagtctta gctgtgaatatggctggaagtgtgtcttctgcctgggtctcagaaagaacgggagaatca gcacctgtattcatgatccctccttcagtctttcccctctcttcgtactctctcaatatc tcctgggagaagccagcagataatgttacaagaggaaaagttgtggggtatgacatcaat atgctttctgaacaatcacctcaacagtctattcccatggcgttttcacagctgttgcac actgctaaatcccaagaactatcttacactgtagaaggactgaaaccttataggatatat gagtttactattactctctgcaattcagttggttgtgtgaccagtgcttcgggagcagga caaactttagcagcagcaccagcacaactgaggccacctctggttaaaggaatcaacagc acaacaatccatcttaggtggtttccacctgaagaactgaatggaccctctcctatatat cagctggaaaggagagagtcatctctaccagctctgatgaccacgatgatgaaaggaatc cgtttcataggaaatgggtattgtaaatttcccagctccactcacccagtcaatacagac ttcactggcattaaggccagctttcgaacaaaagtgcctgaaggtttgattgtctttgca gcatcacctggcaatcaggaagagtattttgcacttcagttgaagaagggacgtctttat tttctttttgatcctcaggggtcaccagtggaagtaactacaactaatgatcatggcaaa caatatagtgatggaaaatggcatgaaataattgctattaggcatcaggcttttggccaa atcactctggatgggatatatacaggttcctctgccatcctgaatggtagtactgttatt ggagataacacaggagtctttctgggagggctcccgcgaagttataccatcctcaggaag gatcctgagataatccaaaaaggttttgtgggctgtctcaaggatgtacattttatgaag aattacaatccgtcagctatttgggaacctctggattggcagagttctgaagaacaaatc aacgtgtataacagctgggagggatgtcccgcttcattaaatgagggagctcagttccta ggagcagggttcctggaacttcatccatatatgtttcatggtggaatgaactttgagatt tcctttaagttcagaactgaccaattaaatggattgcttcttttcgtttataacaaagat ggacctgattttcttgctatggagctgaaaagtggaatattgaccttccggttaaatacc agtcttgcctttacacaagtggatctattgctggggctatcctattgtaatggaaagtgg aataaagtcattattaaaaaggaaggctctttcatatcagcaagtgtgaatggactgatg aagcatgcatcggagtccggagaccagccactggtggtgaattcaccagtttatgtggga ggaatcccacaggaactgctgaactcttatcaacatttgtgtttggaacaaggtttcggt ggttgcatgaaggatgttaaatttacacggggtgctgtcgttaacttggcatctgtgtcc agcggtgctgtcagagtcaatctggatggatgcctatcaactgacagtgctgttaactgc aggggaaatgactccatcctggtttaccagggaaaagagcagagtgtttacgagggtggt ctccagccttttacagaatacctgtatcgagtgatagcctcgcatgaaggaggttcagta tatagtgattggagtcgaggacgtacaacaggagcagctccacaaagtgtgccaactccc tcaagagtccgcagcttaaatggatacagcattgaggtgacctgggatgaacctgttgtc agaggtgtaattgagaagtacattctgaaagcctatagtgaggacagcacccgtccaccc cgcatgccctctgccagtgctgaatttgtcaatacaagcaacctcacaggcatattgaca ggcttgctacccttcaaaaactatgcagtaaccctaactgcttgcactttggctggctgt actgagagctcacatgcattgaacatctctactccacaagaagccccacaagaggttcag ccaccagtagccaaatcccttcccagttctttgctgctctcctggaacccacccaaaaag gcaaatggtattataactcagtactgtttatacatggatgggaggctgatctattcaggc agtgaggagaactacatagtcacagatttagcagtatttacaccccaccagtttctacta agtgcatgcacacatgtgggctgtacaaacagttcctgggtcctactgtacacagcacag ctgccaccagaacacgtggattccccagttctgactgtcctggattctagaactatacac atacagtggaaacaaccaagaaaaataagtgggattctggaacgctatgtattatatatg tcaaaccatacacatgattttacaatttggagtgtcatctataacagtacagaacttttc caggatcatatgctacaatacgttttacctggtaataaatatctcatcaagctgggagct tgcacaggtggtgggtgcacagtgagtgaggccagtgaggccctaactgacgaggacata cccgaaggcgtgccagcccccaaagcccactcatattcacctgactcctttaatgtctcc tggactgagcctgaatatccgaatggtgttatcacgagttatggattatatctagatggt atattaatccacaattcctcagaactcagctatcgtgcttacggatttgctccttggagt ttacattccttcagagtccaagcatgcacggccaaaggttgtgctctgggcccactggtg gaaaatcgaactctagaagctcctcctgaaggaacagtaaatgtgtttgtcaaaacacag ggatcccggaaagcccacgtgaggtgggaagcaccttttcgccctaatggactcttaaca cactcagtccttttcactgggatattctatgtagacccagtaggtaataactacaccctt ctgaatgtcacaaaagtcatgtacagcggagaagagacaaacctttgggtgctcatcgat gggctggttccttttaccaactatactgtacaagtgaatatttcaaatagccaaggcagc ttgataactgatcctataacaattgcaatgcctccaggagctccagatggcgtgctgcct cccaggctttcatctgccactccaaccagtcttcaggttgtctggtctacaccagctcgt aataacgctcctggctctcccagataccaactccagatgaggtctggcgactccacccat ggatttctagagttattttccaatccttctgcatcgttaagctatgaagtgagtgatctc caaccgtacacagagtatatgtttcggttggttgcctccaatggatttggcagtgcacat agttcttggattccattcatgaccgcagaggacaaacctggacctgtagttcctccgatt cttctggatgtgaagtcaagaatgatgttggtcacctggcagcatcctagaaaatccaat ggggttattacccattataacatttatctacatggccgtctatacttgagaactcctgga aatgtcactaattgcacagtgatgcatttacacccatacactgcctataagtttcaggta gaagcctgcacttcaaaaggatgttccctttcaccagagtcccagactgtatggacactc ccaggggcaccggaagggatcccaagtccagagctgttctctgatactccaacatctgtg attatatcttggcaaccccctacccaccccaatggcttggtggagaatttcacaattgag agaagagtcaaaggaaaggaagaagttactaccctggtgactctcccgaggagtcattcc atgaggtttattgacaagacttctgctcttagcccatggacaaaatatgaatatcgggta ctgatgagcactcttcatggaggcacaaacagcagtgcttgggtagaagttaccacaaga ccctcacgacctgctggggtgcagccacctgtggtgacagtgctggaacccgatgcagtc caggtcacttggaaacccccactcatccagaacggagacatacttagctatgagattcac atgcctgaccctcacatcactttaaccaatgtgacttccgcagtgttaagtcaaaaagtt actcatctgattcctttcactaattattctgtcaccattgttgcttgctcagggggtaat gggtaccttggagggtgcacagagagtttacctacctatgttaccactcaccccaccgta cctcagaatgttggcccattgtctgtgattccactaagtgaatcatatgttgtgatttct tggcaaccaccatccaagccaaatggacctaatttgagatatgagcttctgagacgtaaa atccagcagccacttgcatcaaatcccccagaagatttaaatcggtggcacaatatttat tcaggaactcagtggctttatgaagataagggtcttagcaggtttacaacctatgaatat atgctcttcgtacacaacagtgtgggttttacaccgagccgagaagtgactgtgacaacg ttagctggtcttccagagagaggagccaatctcactgcgagtgtccttaaccacacagcc atcgacgtgaggtgggctaaaccaactgttcaagacctacaaggtgaagttgaatattac acacttttttggagttctgctacctcaaacgactctctaaaaatcttgccagatgtaaac tctcatgtcattggccacctaaagccaaacacagagtattggatctttatctctgtcttc aatggagtccacagcatcaacagtgcaggacttcatgcaaccacttgcgatggggagcct cagggcatgcttcctccagaggttgtcatcatcaacagtacagctgtacgtgtcatctgg acatctccttcaaacccaaatggtgttgtcactgagtattctatctatgtaaataataag ctctacaagactggaatgaatgtgcctgggtcgtttattctgagagacctgtctcccttc actatctatgacattcaggttgaagtctgcacaatatatgcctgcgtgaaaagcaatgga acccaaattaccactgtggaagacactccaagtgatataccaacacccacaattcgtggc atcacttcaagatctcttcaaattgattgggtgtctccacggaagccaaatggcatcatt cttggatatgatctcctatggaaaacatggtatccatgcgctaaaactcaaaagttagtg caggatcagagtgatgagctctgcaaggcagtgaggtgtcaaaaacctgaatctatctgt ggacacatttgctattcttctgaagctaaggtttgttgtaacggagtgctctataacccc aagcctggacatcgctgttgtgaagaaaagtatatcccgtttgttctgaattctactgga gtttgttgtggtggccgaatacaggaggcacaaccaaatcatcagtgctgctctgggtat tacgctagaattctaccaggtgaagtatgctgtccagatgaacagcacaatcgggtttct gttggcattggtgattcctgctgtggcagaatgccgtactccacctcaggaaaccagatt tgctgtgctgggaggcttcatgatggccatggccagaagtgctgtggcagacagattgtg agcaacgatttagagtgttgtggtggagaagaaggagtggtgtacaatcgccttccaggt atgttctgttgtgggcaggattatgtgaatatgtcagataccatatgctgctcagcttcc agtggagagtctaaagcacatattaaaaagaatgacccggtgccagtaaaatgctgtgag actgaacttattccaaagagccagaaatgctgtaatggagttggatataatcctttgaaa tatgtttgctctgacaagatttcaactggaatgatgatgaaggaaaccaaagagtgcagg atcctctgcccagcatctatggaagccacagaacattgtggcaggtgtgacttcaacttt accagccacatttgcactgtgataagagggtctcacaattccacagggaaggcatcaatt gaagaaatgtgttcatctgccgaagaaaccattcatacagggagtgtaaacacgtactct tacacagatgtgaacctcaagccctacatgacatatgagtacaggatttctgcctggaac agctatgggcgaggactcagcaaagctgtgagagccagaacaaaagaagatgtgcctcaa ggagtgagtccccctacgtggaccaaaatagacaatcttgaagatacaattgtcttaaac tggagaaaacctatacaatcaaatggtcctattatttactacatccttcttcgaaatgga attgaacgttttcggggaacatcactgagcttctctgataaagagggaattcaaccattt caggaatattcatatcagctgaaagcttgcacggttgctggctgtgccaccagtagcaag gtagttgcagctactacccaaggagttccggagagcatcctgccaccaagcatcacagcc ctaagtgcagtggctctgcatctgagctggagtgtccctgagaaatcaaacggcgtcatt aaagagtaccagatcaggcaggttgggaaaggtctcatccacactgacaccactgacagg agacagcatacggtcacaggtctccagccatacaccaactacagcttcactcttacagct tgtacatctgctgggtgcacttcaagcgagccttttctaggtcagacactgcaggcagct cctgaaggagtttgggtgacacctcgacacattatcatcaattctacaacagtggaatta tattggagtctgccagaaaagcccaatggcctcgtttctcaatatcaattgagtcgtaat ggaaacttgcttttcctgggtggcagtgaggagcagaatttcactgataaaaacctggag cccaatagcagatacacttacaagttagaagtcaaaactggaggtggcagcagtgctagt gatgattacattgttcaaacacctatgtcaacaccagaagaaatctatcctccatataat atcacagtaattgggccttattctatatttgtagcttggataccaccagggatcctcatc cccgaaattcctgtggagtacaatgtcttactcaatgatggaagtgtaacacctctggcc ttctccgttggtcatcatcaatccacccttctggaaaatttgactccattcacacagtat gagataaggatacaagcatgtcaaaatggaagttgtggagttagcagtaggatgtttgtc aaaacacctgaagcagccccaatggatcttaattctcctgttcttaaggcactggggtca gcttgcatagagattaagtggatgccacctgaaaaaccaaatggaatcatcatcaactac tttatttacagacgccctgctggcattgaagaggagtctgttttatttgtctggtcagaa ggagcccttgaatttatggatgaaggagacaccctgaggcctttcacactctacgaatat cgggtcagagcctgtaactccaagggttcagtggagagtctgtggtcattaacacaaact ctggaagctccacctcaagattttccagctccttgggctcaagccacgagtgctcattca gttctgttgaattggacaaagccagaatctcccaatggcattatctcccattaccgtgtg gtctaccaggagagacccgacgatcctacatttaacagccctaccgtgcatgctttcaca gtgaagggaacaagccatcaagcccacctgtacgggttagaaccattcacaacatatcgc attggtgttgtggctgcaaaccatgcaggagaaattttaagcccttggactctgattcaa accttagaatcttccccaagtggactgagaaactttatagtagaacagaaagagaatggc cgggcattgctactacagtggtcagaacctatgagaaccaatggtgtgattaagacatac aacatcttcagtgacgggttcctggagtactctggtttgaatcgtcagtttctcttccgc cgcctggatcctttcactctctacacactgaccctggaggcctgcaccagagcaggttgt gcacactcggcgcctcagcctctgtggacagatgaagcccctccagactctcagctggct cctactgtccactctgtgaagtccaccagtgttgagctgagctggtctgagcctgttaac ccaaatggaaaaataattcgctatgaagtgattcgcagatgcttcgagggaaaagcttgg ggaaatcagacaatccaggccgacgagaaaattgttttcacagaatataacactgaaagg aatacatttatgtataatgacacaggtttgcaaccatggacgcagtgtgaatataaaatc tacacttggaattcagctgggcatacctgtagctcttggaatgtggtgaggacattgcaa gcacctccagaaggtctctctccacctgtgatatcctatgtttctatgaatccccaaaaa ctgctgatttcctggatcccaccagaacagtctaatggtattatccagtcctataggctt caaaggaatgaaatgctctatccttttagctttgatcctgtgactttcaattacactgat gaagagcttcttcctttttccacctatagctatgcactccaagcctgcacgagtggagga tgctccaccagcaaacccaccagcatcacaactctggaggctgctccatcagaagtcagc cctccagatctttgggccgtcagtgccactcaaatgaatgtatgttggtcaccgcccaca gtgcaaaatggaaagattactaaatatttagttagatatgataataaagagtcccttgct ggccagggcctgtgcctgctggtttcccacctgcagccttactctcagtataacttctcc cttgtagcctgcacgaatggaggttgcacagctagtgtgtcaaaatctgcctggacaatg gaggccctgccagagaacatggactctccaacattgcaagtcacaggctcagaatcaata gaaatcacctggaaacctccaagaaacccaaatggccagatcagaagttatgaacttagg agggatggaaccattgtatatacaggcttggaaacacgctatcgtgattttactctcacc ccaggtgtggagtatagctacacagtaactgccagcaacagccaagggggtattttgagt cctcttgtcaaagatcgaaccagcccctcagcaccctcagggatggaacctccaaaattg caggccaggggtcctcaggagatcttagtgaactgggaccctccagtgagaacaaatggt gatatcatcaattataccctcttcatccgtgaactatttgaaagagaaactaaaatcata cacataaacacaactcataattcttttggtatgcagtcatatatagtaaaccagctgaag ccatttcacaggtatgaaatacgaattcaagcgtgcaccaccctgggatgtgcatcaagt gactggacattcatacagacccctgagattgcacctttgatgcaaccccctccacatctg gaggtacaaatggctccaggaggattccagccaactgtttctcttttgtggacaggaccg ctgcagccaaatggaaaagttttgtattacgaattatacagaagacaaatagcaactcag cctagaaaatccaatccagtcctaatctataacggaagctcaacatcttttatagattcc gaactattgcctttcacagagtatgagtatcaggtctgggcagtgaattctgcaggaaaa gcccccagtagctggacatggtgcagaaccgggccagccccaccagaaggtctcagagcc cccacgttccatgtgatctcttctacccaagcagtggtcaacatcagtgcccctgggaag cccaacgggatcgtcagtctctacaggctgttctccagcagcgcccatggggctgagaca gtgctatccgaaggcatggccacccagcagactctccatggccttcaagccttcactaac tactctattggagtagaggcctgcacctgcttcaactgttgcagcaaaggaccgacagct gaactgagaacccatcctgccccaccctcaggactgtcctctccacaaatcgggacgctg gcctcaaggacggcctccttccggtggagtccccccatgttccccaatggtgtcattcac agctatgaactccaattccacgtggcttgccctcctgactcagccctcccctgtactccc agccaaatagaaacaaagtacacggggctggggcagaaagccagccttgggggtctccag ccctacaccacatacaagctgagagtggtggcacacaacgaggtgggcagtacggcttcc gagtggatcagtttcaccacccaaaaagaattgcctcagtaccgagccccattttcggtg gacagcaatttgtctgtggtgtgtgtgaactggagtgacaccttcctcctgaacggccaa ctgaaggagtacgtgttaaccgacggagggcgacgcgtgtacagcggcttggacaccacc ctctacataccgagaacggcggacaaaaccttctttttccaggtcatctgcacgactgac gaaggaagtgttaagacgccgttgatccaatatgatacctctactggacttggcttggtc ctaacaactcctgggaaaaagaagggatcgcggagcaaaagcacagagttctacagcgag ctgtggttcatagtgttaatggcgatgctgggcttgatcttgttggccatttttctgtcc ctgatactacaaagaaaaatccacaaagagccatatatcagagaaagacctcccttggta cctcttcagaagaggatgtctccattgaatgtttacccaccgggggaaaaccatatgggg ttagccgataccaaaattccccggtctgggacacctgtgagtatccgcagcaaccggagt gcatgtgtcctgcgcatcccgagtcaaaaccaaaccagcctaacctactcccagggttct cttcaccgcagcgtcagccagctcatggacattcaagacaagaaagtcttgatggacaac tcactgtgggaagccatcatgggccacaacagtggactgtatgtggatgaagaggacctg atgaacgccatcaaggatttcagctcagtgactaaggaacgcaccacattcacagacacc cacctgtaa

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