Homo sapiens (human): 8036
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Entry
8036 CDS
T01001
Symbol
SHOC2, NSLH1, SIAA0862, SOC2, SUR8
Name
(RefSeq) SHOC2 leucine rich repeat scaffold protein
KO
K19613
leucine-rich repeat protein SHOC2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04014
Ras signaling pathway
Network
nt06526
MAPK signaling
Element
N01598
Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H00523
Noonan syndrome and related disorders
H02191
Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
8036 (SHOC2)
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Gene cluster
GFIT
Motif
Pfam:
LRR_8
LRR_14
LRR_4
LRR_1
LRR_LRWD1
LRR_9
LRR_13
NKWYS
Motif
Other DBs
NCBI-GeneID:
8036
NCBI-ProteinID:
NP_001311265
OMIM:
602775
HGNC:
15454
Ensembl:
ENSG00000108061
UniProt:
Q9UQ13
Structure
PDB
PDBj
LinkDB
All DBs
Position
10:110919370..111013665
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AA seq
582 aa
AA seq
DB search
MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAA
QPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIK
ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK
LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL
ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP
RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL
NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED
VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN
NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC
SKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV
NT seq
1749 nt
NT seq
+upstream
nt +downstream
nt
atgagtagtagtttaggaaaagaaaaagactctaaagaaaaagatcccaaagtaccatca
gccaaggaaagagaaaaggaggcaaaagcctctggaggttttgggaaagagagcaaagaa
aaagaacctaagaccaaagggaaagatgccaaagatggaaagaaggactccagtgctgcc
caaccaggggtggcattttcagttgacaatacgatcaaacggccaaacccagcacctggg
actagaaaaaaatccagcaatgcagaggtgattaaagagctcaacaaatgccgggaagag
aattcaatgcgtttggacttatccaagagatctatacacatattgccatcatcaatcaaa
gagttgactcaattaacagaactttatttatacagtaacaaattgcagtccctcccagca
gaggtgggatgtttagtaaatctcatgacactggctctaagtgaaaattcacttaccagt
ttgcctgactctcttgataacttgaagaagctgcggatgcttgatttacggcataataaa
ctgagagaaattccttcagtggtgtataggctggattctctcaccactctttaccttcgc
tttaatcgtataactactgtggaaaaggacatcaaaaacttgtcaaaactcagcatgctt
agcattcgagagaacaaaattaaacaactacctgctgaaattggtgaattatgtaacctc
attacgctggatgtagctcacaatcaacttgaacaccttccaaaggagattggaaactgt
acacagataaccaaccttgacttgcagcacaatgaactgctagacctcccagatactata
ggaaacctgtccagtttaagtcgtcttggtctgagatataacagactgtcagcaataccc
agatcattagcaaaatgcagtgcacttgaagaattaaatttagagaacaataacatttct
actttaccagagagtcttttatcaagtcttgtgaaactgaatagtttgaccttagctaga
aattgcttccagttgtatccagtgggtggtccatctcagttttctaccatctattccctc
aacatggaacacaatcgaatcaacaaaattccatttggaattttctccagagcaaaagta
ttaagtaagctgaatatgaaggacaatcagttaacatcacttcccttggattttggaact
tggaccagtatggtagaattgaatttagccactaatcagctcacaaagatccctgaggat
gtgtctggtctcgtttctcttgaggttcttatcttatcaaacaatcttctaaagaagctt
ccccatggtcttggaaaccttaggaagttaagagagttggatctagaagagaacaaattg
gaatccttgccaaatgaaattgcatatcttaaggatttacagaaattagtcttgacaaac
aaccagttgaccactcttcccagaggcattggtcaccttactaatctcacacatctgggc
cttggagagaacctacttactcaccttcctgaagaaattggtacactggagaacctagaa
gaactgtatttgaatgacaaccccaacctgcatagccttccctttgagctggcactctgc
agcaagctttcaatcatgagtattgagaactgtccactcagtcaccttccacctcagatt
gttgctggggggccttctttcatcattcagttcttaaagatgcagggtccatatcgtgcc
atggtctga
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