Homo sapiens (human): 8216
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Entry
8216 CDS
T01001
Symbol
LZTR1, BTBD29, LZTR-1, NS10, NS2, SWNTS2
Name
(RefSeq) leucine zipper like post translational regulator 1
KO
K23330
leucine-zipper-like transcriptional regulator 1
Organism
hsa
Homo sapiens (human)
Network
nt06526
MAPK signaling
Element
N01596
Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex
Disease
H00523
Noonan syndrome and related disorders
H01738
Noonan syndrome
H02945
Schwannomatosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
8216 (LZTR1)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit type E3
Cul3 complex
Adoptor and target recognizing subunit (BTB)
8216 (LZTR1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Kelch_KLHDC2_KLHL20_DRC7
Beta-prop_ATRN-LZTR1
Kelch_3
Kelch_1
Kelch_4
Kelch_5
BTB
Kelch_6
Kelch_2
NANM
BACK
RAG2
BACK_BPM_SPOP
Motif
Other DBs
NCBI-GeneID:
8216
NCBI-ProteinID:
NP_006758
OMIM:
600574
HGNC:
6742
Ensembl:
ENSG00000099949
UniProt:
Q8N653
A0A384NL67
LinkDB
All DBs
Position
22:20982297..20999032
Genome browser
AA seq
840 aa
AA seq
DB search
MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPC
DEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYH
HSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGA
TVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKM
FVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFG
GAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEERVGFKK
SRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ
FSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKITQARER
LAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKIKYPRKGH
VEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHCLN
FVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLE
GAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAF
ESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA
DKTQALDMKRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI
NT seq
2523 nt
NT seq
+upstream
nt +downstream
nt
atggctggaccgggcagcacgggggggcagatcggggctgcggccctggcaggcggcgcg
cggtccaaggtagccccgagcgtggacttcgaccatagctgctcggacagtgtcgagtac
ctgacgctcaacttcgggcccttcgaaacagtgcatcgctggcggcgcctcccgccctgc
gacgagttcgtgggtgcccggcgcagcaagcacacagtggtggcctataaagatgccatt
tatgtatttggtggagacaatgggaagaccatgctcaatgacctcctgcggttcgatgtg
aaagactgctcctggtgcagggcctttaccactgggaccccaccggccccccgttaccac
cactcggccgtcgtctatgggagcagcatgtttgtctttgggggttacactggggacatt
tattccaattctaacttgaagaataaaaacgacctctttgaatacaagtttgcaactggc
cagtggacggagtggaaaattgaaggacggttgccagtcgctaggtcagcccatggggcc
acggtgtacagtgacaagctgtggatctttgctggctatgacggcaacgccaggttgaat
gacatgtggacaattggcctccaggaccgagagctcacctgctgggaggaggtggcccag
agtggcgagatccccccatcttgctgcaacttccccgtggctgtgtgccgggacaagatg
tttgtattctctgggcaaagcggagccaaaataaccaacaacctcttccagtttgaattc
aaggacaagacgtggacacgcatcccaactgaacacctgctccggggctccccaccaccc
ccgcagcggcgctacgggcataccatggtggcctttgaccgccacctctatgtgtttggg
ggtgcggccgacaacacgctgcccaacgagctgcactgctatgacgtggacttccagacc
tgggaggtcgtccagcccagctccgacagcgaggttggtggggctgaagtgcccgagcga
gcctgtgcttccgaggaggtgcccaccctgacctatgaggagcgggttggcttcaagaag
tcccgagatgtgtttggcctggactttggcaccacctcagccaagcagcccacccagcct
gcctcggagctgcccagtgggaggctcttccacgcggctgctgtcatctcggacgccatg
tacatcttcgggggcacggtggacaacaacatccgcagcggggagatgtacaggttccag
ttctcctgttaccctaaatgcacgctgcacgaggactacgggcggctgtgggagagccgc
cagttctgcgacgtggagttcgtgctgggtgagaaggaggagtgcgtgcagggccacgta
gccattgtcacagcgcggagccgctggcttcgcaggaagatcacgcaggcgcgggagagg
ctggcccagaagctggagcaggaggccgccccagttcccagggaggcccccggcgtggct
gctggtggggcccggccgcccctgctgcacgtggccatccgggaggccgaggcccggccc
ttcgaggtgctcatgcagttcctctacaccgacaagatcaaatacccacggaaaggccat
gtggaggatgtgctgctcatcatggatgtgtacaaactggcactgagcttccagttgtgc
cgcctggagcagctgtgccgccagtacatcgaggcctccgtggacctgcagaacgtgctg
gttgtgtgcgagagtgccgcccggctgcagctgagccaactcaaggagcactgcctgaac
ttcgtggtaaaggagtcccacttcaaccaggtgatcatgatgaaggagttcgagcgcctc
tcctctccactgatagtggagattgtgcggcggaagcagcagccgccccctcgcactccc
ttggaccagccagtggacattggcacatctctgatccaggacatgaaggcatacctggag
ggagcgggcgcggaattctgtgacatcactctgttgcttgacgggcacccacggccagcc
cacaaggctatcctggccgcccgctccagctactttgaagccatgttccggtccttcatg
cccgaagatgggcaggtgaacatctccatcggggagatggtgcccagcaggcaggccttc
gagtccatgctgcgctacatctactacggcgaggtcaacatgccgcccgaggactcgctc
tacttgtttgcggccccctactactacggcttctacaacaaccggctgcaggcgtactgc
aagcagaacctggagatgaacgtgacggtgcagaacgtgctgcagatcctggaggcagct
gacaaaacgcaggcactggacatgaagcggcactgcctgcacatcattgtgcaccagttc
accaaggtctccaagttgcccaccctgcggtcgctgagccagcagctgctgctggacatc
atagactccctggcctcccacatctcagacaagcagtgcgcagagctgggcgccgacatc
tga
Homo sapiens (human): 8452
Help
Entry
8452 CDS
T01001
Symbol
CUL3, CUL-3, NEDAUS, PHA2E
Name
(RefSeq) cullin 3
KO
K03869
cullin 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04340
Hedgehog signaling pathway
Network
nt06526
MAPK signaling
nt06541
Cytoskeleton in neurons
Element
N01596
Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex
N01855
Neurofilament regulation, ubiqutination by Gigaxonin
Disease
H00243
Hyperkalemic distal renal tubular acidosis (RTA type 4)
H02310
Renal tubular acidosis
H02715
Neurodevelopmental disorder with defects of ubiquitin-proteasome system
H02864
Neurodevelopmental disorder with or without autism or seizures
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
8452 (CUL3)
09130 Environmental Information Processing
09132 Signal transduction
04340 Hedgehog signaling pathway
8452 (CUL3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
8452 (CUL3)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
8452 (CUL3)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit type E3
Cul3 complex
Cullin
8452 (CUL3)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
SSBR (single strand breaks repair)
NER (nucleotide excision repair)
Other NER factors
8452 (CUL3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cullin
Cullin_Nedd8
Stu2_CTS
RhgB_N
DUF6655
WAC_Acf1_DNA_bd
Motif
Other DBs
NCBI-GeneID:
8452
NCBI-ProteinID:
NP_003581
OMIM:
603136
HGNC:
2553
Ensembl:
ENSG00000036257
UniProt:
Q13618
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(224470150..224585363)
Genome browser
AA seq
768 aa
AA seq
DB search
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN
AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR
DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR
INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY
KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR
FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS
NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL
AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT
ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT
VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN
VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA
NT seq
2307 nt
NT seq
+upstream
nt +downstream
nt
atgtcgaatctgagcaaaggcacgggcagccggaaggacaccaagatgcggatccgggcc
tttccgatgaccatggatgaaaaatatgtaaacagcatttgggaccttctgaaaaatgca
attcaagaaatccagcgtaagaataacagtggtcttagttttgaggagctctatagaaat
gcatatacaatggttttgcataaacatggagaaaagctctacactggactaagagaagtt
gttaccgaacatctcataaataaggtgcgagaagatgtactaaattcattgaataacaac
tttcttcaaacgctaaatcaagcttggaatgatcatcaaacagctatggtgatgattaga
gacatactaatgtacatggaccgtgtgtatgtacaacaaaataatgtggagaacgtctac
aatttgggattaattatttttcgagatcaagttgtacgttatgggtgtattagggatcat
ctacggcaaactctattggatatgattgcaagagagcggaaaggagaagtcgtagacaga
ggcgcaataagaaatgcttgccagatgttaatgattttaggtctcgaaggaagatcagtc
tatgaagaagattttgaggctccttttttggaaatgtctgcagaattttttcagatggaa
agccagaaatttttagcagaaaatagtgcttcagtatatataaagaaagtagaagctaga
attaatgaagaaatagaacgagtgatgcactgccttgacaaatcaacggaagaaccaatt
gtaaaggtggttgaaagggaactcatttccaagcacatgaagactatagtagaaatggag
aattctgggctagtacatatgttgaaaaatggaaagacagaagaccttggttgcatgtac
aagttatttagtcgtgtgccaaatggtttgaaaacaatgtgtgagtgtatgagttcctat
ttgagggagcaaggtaaagctcttgtttctgaagaaggagaaggaaagaatcctgttgac
tatatccagggcttattggatctgaagagtaggttcgatcgcttcctcctggaatcattc
aacaatgaccgtctctttaaacaaactattgcgggtgactttgagtattttctcaacctc
aactccaggtctcctgaatacctctcattatttattgatgataagctgaaaaagggagtc
aaagggctaacagaacaagaagtagaaacaatattggataaagcaatggtcctttttagg
tttatgcaagaaaaagatgtatttgaacgttattataaacaacacttggcaaggagactt
ctcacaaataaaagtgtttctgatgactctgaaaaaaacatgatatctaagttaaagact
gaatgtggatgtcagttcacgtcaaaactggaaggaatgtttagggatatgagcatctca
aacacaacgatggatgaattcaggcaacatctacaggcaactggtgtatctttaggtggt
gttgatcttacagtccgggtgctcacgacaggatattggcccactcagtcagccacacca
aagtgcaacatcccaccagcaccaagacatgcttttgagatattcagaaggttctactta
gccaaacacagtggtcgacagctcacactccagcatcatatgggttctgcagatctcaat
gccacattttatggaccagttaaaaaggaagatggatctgaagttggtgttggaggtgca
caagtaactggctctaatacacggaagcacatattgcaagtttccactttccagatgacc
atattaatgctctttaataatagagaaaaatacacatttgaggaaattcagcaagagaca
gatatccctgaaagagagcttgttagagccctacagtccctcgcctgtggtaaaccaaca
cagcgggttcttacaaaagaacccaaatcaaaggaaatagaaaatggtcatatatttaca
gttaatgatcaattcacatccaaactacacagagtcaagattcaaacagttgctgccaaa
caaggtgaatccgacccagagaggaaagaaacaaggcagaaagtagacgacgacagaaaa
catgagatagaagctgctatagtgcggataatgaaatctagaaagaagatgcagcacaat
gttctagtagcggaggtaactcagcagttgaaggcgcgattcttaccaagtccagttgtt
attaagaaacgtattgaaggacttattgagagagaatatttggcacgaacacctgaggat
cgcaaagtatacacatatgtagcataa
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