Homo sapiens (human): 83737
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Entry
83737 CDS
T01001
Symbol
ITCH, ADMFD, AIF4, AIP4, NAPP1
Name
(RefSeq) itchy E3 ubiquitin protein ligase
KO
K05632
E3 ubiquitin-protein ligase Itchy [EC:
2.3.2.26
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04120
Ubiquitin mediated proteolysis
hsa04144
Endocytosis
hsa04330
Notch signaling pathway
hsa04668
TNF signaling pathway
hsa04932
Non-alcoholic fatty liver disease
Disease
H01232
Syndromic multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
83737 (ITCH)
09130 Environmental Information Processing
09132 Signal transduction
04330 Notch signaling pathway
83737 (ITCH)
04668 TNF signaling pathway
83737 (ITCH)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
83737 (ITCH)
09160 Human Diseases
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
83737 (ITCH)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
83737 (ITCH)
04121 Ubiquitin system [BR:
hsa04121
]
83737 (ITCH)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.26 HECT-type E3 ubiquitin transferase
83737 (ITCH)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Ubiquitin E3 ligases
83737 (ITCH)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
HECT type E3
83737 (ITCH)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HECT
WW
C2
Motif
Other DBs
NCBI-GeneID:
83737
NCBI-ProteinID:
NP_001244066
OMIM:
606409
HGNC:
13890
Ensembl:
ENSG00000078747
UniProt:
Q96J02
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:34363273..34511773
Genome browser
AA seq
903 aa
AA seq
DB search
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL
CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
GQE
NT seq
2712 nt
NT seq
+upstream
nt +downstream
nt
atgtctgacagtggatcacaacttggttcaatgggtagcctcaccatgaaatcacagctt
cagatcactgtcatctcagcaaaacttaaggaaaataagaagaattggtttggaccaagt
ccttacgtagaggtcacagtagatggacagtcaaagaagacagaaaaatgcaacaacaca
aacagtcccaagtggaagcaaccccttacagttatcgttacccctgtgagtaaattacat
tttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcatta
gatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttgtgactttg
cagcttggaggtgacaaagagccaacagagacaataggagacttgtcaatttgtcttgat
gggctacagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaaatggg
gtttcgctctgtttgcccaggctggagtgcaatagtgcgatctcggctcactgcaacctc
tgcctcccgggtttaagtgattctcctatctcagcctcccgagtagctgggtttacaggt
gcttctcagaatgatgatggctccagatccaaggatgaaacaagagtgagcacaaatgga
tcagatgaccctgaagatgcaggagctggtgaaaataggagagtcagtgggaataattct
ccatcactctcaaatggtggttttaaaccttctagacctccaagaccttcacgaccacca
ccacccaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagt
gatgggtctagtacaggctctctgccgccgacaaatacaaatacaaatacatctgaagga
gcaacatctggattaataattcctcttactatatctggaggctcaggccctaggccatta
aatcctgtaactcaagctcccttgccacctggttgggagcagagagtggaccagcacggg
cgagtttactatgtagatcatgttgagaaaagaacaacatgggatagaccagaacctcta
cctcctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttc
acaagaacaacaacgtggcagaggccaacactggaatccgtccggaactatgaacaatgg
cagctacagcgtagtcagcttcaaggagcaatgcagcagtttaaccagagattcatttat
gggaatcaagatttatttgctacatcacaaagtaaagaatttgatcctcttggtccattg
ccacctggatgggagaagagaacagacagcaatggcagagtatatttcgtcaaccacaac
acacgaattacacaatgggaagaccccagaagtcaaggtcaattaaatgaaaagccctta
cctgaaggttgggaaatgagattcacagtggatggaattccatattttgtggaccacaat
agaagaactaccacctatatagatccccgcacaggaaaatctgccctagacaatggacct
cagatagcctatgttcgggacttcaaagcaaaggttcagtatttccggttctggtgtcag
caactggccatgccacagcacataaagattacagtgacaagaaaaacattgtttgaggat
tcctttcaacagataatgagcttcagtccccaagatctgcgaagacgtttgtgggtgatt
tttccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttg
tcacatgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactac
tgcttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgtttt
attggcagatttattgccatggctctgttccatgggaaattcatagacacgggtttttct
ttaccattctataagcgtatcttgaacaaaccagttggactcaaggatttagaatctatt
gatccagaattttacaattctctcatctgggttaaggaaaacaatattgaggaatgtgat
ttggaaatgtacttctccgttgacaaagaaattctaggtgaaattaagagtcatgatctg
aaacctaatggtggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatg
gtagctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttctttgaaggc
tttaatgaaattcttccccagcaatatttgcaatactttgatgcaaaggaattagaggtc
cttttatgtggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgt
cattatgcaaggaccagcaaacaaatcatgtggttttggcagtttgttaaagaaattgat
aatgagaagagaatgagacttctgcagtttgttactggaacctgccgattgccagtagga
ggatttgctgatctcatggggagcaatggaccacagaaattctgcattgaaaaagttggg
aaagaaaattggctacccagaagtcatacctgttttaatcgcctggacctgccaccatac
aagagctatgagcaactgaaggaaaagctgttgtttgccatagaagaaacagaaggattt
ggacaagagtaa
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