Homo sapiens (human): 8435
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Entry
8435 CDS
T01001
Symbol
SOAT2, ACACT2, ACAT2, ARGP2
Name
(RefSeq) sterol O-acyltransferase 2
KO
K00637
sterol O-acyltransferase [EC:
2.3.1.26
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00100
Steroid biosynthesis
hsa04979
Cholesterol metabolism
Drug target
Avasimibe:
D03012
Cetaben sodium:
D03447
Eldacimibe:
D03734
Lecimibide:
D03735
Melinamide:
D01202
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
8435 (SOAT2)
09150 Organismal Systems
09154 Digestive system
04979 Cholesterol metabolism
8435 (SOAT2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.26 sterol O-acyltransferase
8435 (SOAT2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MBOAT
MBOAT_2
Motif
Other DBs
NCBI-GeneID:
8435
NCBI-ProteinID:
NP_003569
OMIM:
601311
HGNC:
11178
Ensembl:
ENSG00000167780
UniProt:
O75908
Structure
PDB
PDBj
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All DBs
Position
12:53103486..53124535
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AA seq
522 aa
AA seq
DB search
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
NT seq
1569 nt
NT seq
+upstream
nt +downstream
nt
atggagccaggcggggcccgtctgcgtctgcagaggacagaagggctgggaggggagcgg
gagcgccaaccctgtggagatggaaacactgagacgcacagagccccggacttggtacaa
tggacccgacacatggaggctgtgaaggcacaattgctggagcaagcgcagggacaactg
agggagctgctggatcgggccatgcgggaggctatacaatcctacccatcacaagacaaa
cctctgcccccacctcccccaggttccttgagcaggacccaggagccatccctggggaaa
cagaaagttttcatcatccgcaagtccctgcttgatgagctgatggaggtgcagcatttc
cgcaccatctaccacatgttcatcgctggcctgtgtgtcttcatcatcagcaccctggcc
atcgacttcattgatgagggcaggctgctgctggagtttgacctactgatcttcagcttc
ggacagctgccattggcgctggtgacctgggtgcccatgtttctgtccaccctgttggcg
ccgtaccaggccctacggctgtgggccaggggcacctggacgcaggcgacgggcctgggc
tgtgcgctgctagccgcccacgccgtggtgctctgcgcgctgccggtccacgtggccgtg
gagcatcagctcccgccggcctcccgttgtgtcctggtcttcgagcaggttaggttcctg
atgaaaagctactccttcctgagagaggctgtgcctgggacccttcgtgccagacgaggt
gaggggatccaggcccccagtttctccagctacctctacttcctcttctgcccaacactc
atctacagggagacttaccctaggacgccctatgtcaggtggaattatgtggccaagaac
tttgcccaggccctgggatgtgtgctctatgcctgcttcatcctgggccgcctctgtgtt
cctgtctttgccaacatgagccgagagcccttcagcacccgtgccctggtgctctctatc
ctgcatgccacgttgccaggcatcttcatgctgctgctcatcttctttgccttcctccat
tgctggctcaacgcctttgccgagatgctacgatttggagacaggatgttctaccgggac
tggtggaactcaacgtccttctccaactactaccgcacttggaacgtggtggtccatgac
tggctgtacagctacgtgtatcaggatgggctgcggctccttggtgcccgggcccgaggg
gtagccatgctgggtgtgttcctggtctccgcagtggcccatgagtatatcttctgcttc
gtcctggggttcttctatcccgtcatgctgatactcttccttgtcattggaggaatgttg
aacttcatgatgcatgaccagcgcaccggcccggcatggaacgtgctgatgtggaccatg
ctgtttctaggccagggaatccaggtcagcctgtactgccaggagtggtacgcacggcgg
cactgccccttaccccaggcaactttctgggggctggtgacacctcgatcttggtcctgc
catacctag
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