Homo sapiens (human): 8452 Help Entry 8452              CDS       T01001                                  Symbol CUL3, CUL-3, NEDAUS, PHA2E Name (RefSeq) cullin 3   KO K03869   cullin 3 Organism hsa  Homo sapiens (human) Pathway hsa04120   Ubiquitin mediated proteolysis hsa04340   Hedgehog signaling pathway Network nt06526  MAPK signaling   Element N01596   Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex Disease H00243   Hyperkalemic distal renal tubular acidosis (RTA type 4) H02310   Renal tubular acidosis H02715   Neurodevelopmental disorder with defects of ubiquitin-proteasome system Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     8452 (CUL3)  09130 Environmental Information Processing   09132 Signal transduction    04340 Hedgehog signaling pathway     8452 (CUL3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     8452 (CUL3)    03400 DNA repair and recombination proteins [BR:hsa03400]     8452 (CUL3) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   Multi subunit Ring-finger type E3    Cul3 complex     Cullin      8452 (CUL3) DNA repair and recombination proteins [BR:hsa03400]  Eukaryotic type   SSBR (single strand breaks repair)    NER (nucleotide excision repair)     Other NER factors      8452 (CUL3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Cullin Cullin_Nedd8 Stu2_CTS RhgB_N DUF6655 WAC_Acf1_DNA_bd Motif Other DBs NCBI-GeneID:  8452 NCBI-ProteinID:  NP_003581 OMIM:  603136 HGNC:  2553 Ensembl:  ENSG00000036257 Pharos:  Q13618(Tbio) UniProt:  Q13618 Structure PDB LinkDB All DBs Position 2:complement(224470150..224585363) Genome browser AA seq 768 aa AA seqDB search MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA NT seq 2307 nt NT seq  +upstreamnt  +downstreamnt atgtcgaatctgagcaaaggcacgggcagccggaaggacaccaagatgcggatccgggcc tttccgatgaccatggatgaaaaatatgtaaacagcatttgggaccttctgaaaaatgca attcaagaaatccagcgtaagaataacagtggtcttagttttgaggagctctatagaaat gcatatacaatggttttgcataaacatggagaaaagctctacactggactaagagaagtt gttaccgaacatctcataaataaggtgcgagaagatgtactaaattcattgaataacaac tttcttcaaacgctaaatcaagcttggaatgatcatcaaacagctatggtgatgattaga gacatactaatgtacatggaccgtgtgtatgtacaacaaaataatgtggagaacgtctac aatttgggattaattatttttcgagatcaagttgtacgttatgggtgtattagggatcat ctacggcaaactctattggatatgattgcaagagagcggaaaggagaagtcgtagacaga ggcgcaataagaaatgcttgccagatgttaatgattttaggtctcgaaggaagatcagtc tatgaagaagattttgaggctccttttttggaaatgtctgcagaattttttcagatggaa agccagaaatttttagcagaaaatagtgcttcagtatatataaagaaagtagaagctaga attaatgaagaaatagaacgagtgatgcactgccttgacaaatcaacggaagaaccaatt gtaaaggtggttgaaagggaactcatttccaagcacatgaagactatagtagaaatggag aattctgggctagtacatatgttgaaaaatggaaagacagaagaccttggttgcatgtac aagttatttagtcgtgtgccaaatggtttgaaaacaatgtgtgagtgtatgagttcctat ttgagggagcaaggtaaagctcttgtttctgaagaaggagaaggaaagaatcctgttgac tatatccagggcttattggatctgaagagtaggttcgatcgcttcctcctggaatcattc aacaatgaccgtctctttaaacaaactattgcgggtgactttgagtattttctcaacctc aactccaggtctcctgaatacctctcattatttattgatgataagctgaaaaagggagtc aaagggctaacagaacaagaagtagaaacaatattggataaagcaatggtcctttttagg tttatgcaagaaaaagatgtatttgaacgttattataaacaacacttggcaaggagactt ctcacaaataaaagtgtttctgatgactctgaaaaaaacatgatatctaagttaaagact gaatgtggatgtcagttcacgtcaaaactggaaggaatgtttagggatatgagcatctca aacacaacgatggatgaattcaggcaacatctacaggcaactggtgtatctttaggtggt gttgatcttacagtccgggtgctcacgacaggatattggcccactcagtcagccacacca aagtgcaacatcccaccagcaccaagacatgcttttgagatattcagaaggttctactta gccaaacacagtggtcgacagctcacactccagcatcatatgggttctgcagatctcaat gccacattttatggaccagttaaaaaggaagatggatctgaagttggtgttggaggtgca caagtaactggctctaatacacggaagcacatattgcaagtttccactttccagatgacc atattaatgctctttaataatagagaaaaatacacatttgaggaaattcagcaagagaca gatatccctgaaagagagcttgttagagccctacagtccctcgcctgtggtaaaccaaca cagcgggttcttacaaaagaacccaaatcaaaggaaatagaaaatggtcatatatttaca gttaatgatcaattcacatccaaactacacagagtcaagattcaaacagttgctgccaaa caaggtgaatccgacccagagaggaaagaaacaaggcagaaagtagacgacgacagaaaa catgagatagaagctgctatagtgcggataatgaaatctagaaagaagatgcagcacaat gttctagtagcggaggtaactcagcagttgaaggcgcgattcttaccaagtccagttgtt attaagaaacgtattgaaggacttattgagagagaatatttggcacgaacacctgaggat cgcaaagtatacacatatgtagcataa

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