Homo sapiens (human): 84678
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Entry
84678 CDS
T01001
Symbol
KDM2B, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2
Name
(RefSeq) lysine demethylase 2B
KO
K10276
F-box and leucine-rich repeat protein 10/11 [EC:
1.14.11.27
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03083
Polycomb repressive complex
Network
nt06523
Epigenetic regulation by Polycomb complexes
Element
N01586
Activation of PRC2.2 by ubiquitination of H2AK119
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09126 Chromosome
03083 Polycomb repressive complex
84678 (KDM2B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
84678 (KDM2B)
04121 Ubiquitin system [BR:
hsa04121
]
84678 (KDM2B)
03036 Chromosome and associated proteins [BR:
hsa03036
]
84678 (KDM2B)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase
84678 (KDM2B)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
84678 (KDM2B)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
SCF complex
Target recognizing subunit (F-box)
84678 (KDM2B)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
Histone demethylases
84678 (KDM2B)
Polycomb repressive complex (PRC) and associated proteins
Noncanonical PRC1 (PRC1.1)
84678 (KDM2B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PHD_4
zf-CXXC
F-box-like
JHD
F-box
Cupin_8
JmjC
Motif
Other DBs
NCBI-GeneID:
84678
NCBI-ProteinID:
NP_115979
OMIM:
609078
HGNC:
13610
Ensembl:
ENSG00000089094
UniProt:
Q8NHM5
Structure
PDB
LinkDB
All DBs
Position
12:complement(121408461..121582279)
Genome browser
AA seq
1336 aa
AA seq
DB search
MAGPQMGGSAEDHPPRKRHAAEKQKKKTVIYTKCFEFESATQRPIDRQRYDENEDLSDVE
EIVSVRGFSLEEKLRSQLYQGDFVHAMEGKDFNYEYVQREALRVPLIFREKDGLGIKMPD
PDFTVRDVKLLVGSRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSH
TKLEHLVKRPTVVDLVDWVDNMWPQHLKEKQTEATNAIAEMKYPKVKKYCLMSVKGCFTD
FHIDFGGTSVWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIEL
KQGYTFFIPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYY
EMCWYVLERYVYCVTQRSHLTQEYQRESMLIDAPRKPSIDGFSSDSWLEMEEEACDQQPQ
EEEEKDEEGEGRDRAPKPPTDGSTSPTSTPSEDQEALGKKPKAPALRFLKRTLSNESEES
VKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIED
PQALLEGVKNVLKEHADDDPSLAITGVPVVTWPKKTPKNRAVGRPKGKLGPASAVKLAAN
RTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTA
VCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECP
KCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECEEAPRRRSDE
HSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRASSLQTSPGSSSHLSPRPPLGSS
LSPWWRSSLTYFQQQLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDELPEA
PPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQR
TENSLANENQQPIKSEPESEGEEPKRPPGICERPHRFSKGLNGTPRELRHQLGPSLRSPP
RVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSYLSHQ
DLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQ
LSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTD
NRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLT
AVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEGCEQFIAEMSV
SVQFGQVEEKLLQKLS
NT seq
4011 nt
NT seq
+upstream
nt +downstream
nt
atggcgggtccgcaaatggggggatctgcagaggatcaccccccacgaaaaagacatgca
gcagaaaagcaaaaaaagaaaacagttatatatacaaaatgctttgaatttgagtcggcc
acacagcgcccgattgaccgccagcgatacgacgagaacgaggacttgtcggacgtggag
gagatcgtcagcgtccgcggcttcagcctggaggagaagcttcgcagccagctgtaccag
ggggacttcgtgcacgccatggagggcaaagatttcaactatgagtacgtacagagagaa
gctctcagggttcccctgatatttcgagaaaaggatggactgggaattaagatgcctgac
cctgatttcacagtccgagacgtcaaactcctagtggggagccggcggcttgtggacgtg
atggatgtgaacacccagaagggcacggagatgagcatgtcccagtttgtgcgttactac
gagacgcccgaggcccagcgggacaagctgtacaacgtcatcagcctagagttcagccac
accaagctggagcacttggtcaagcgtccgactgtggtagacctggtggactgggtggac
aacatgtggccccagcatctgaaggagaagcagacagaagccacgaacgccattgcagag
atgaagtacccgaaagtgaaaaagtactgtctgatgagcgtgaaaggttgtttcaccgac
ttccacatcgactttggaggcacttccgtttggtaccatgttttccggggtgggaagatt
ttttggctgattcctccaacgctgcacaatttggcgctgtacgaggagtgggtgctgtca
ggcaaacagagtgacatctttctgggagaccgtgtggaacgatgccaaagaattgagctg
aagcagggctacacatttttcatcccttccggttggatccatgccgtctacacccctgta
gactctttggtgttcggcggaaacatcctgcacagctttaacgtgcccatgcagctgcgg
atctacgagatcgaggacaggacgcgggtgcagcccaaattccgttaccccttctactat
gagatgtgctggtatgtcctggagagatacgtgtactgtgtgacccagcgctcccacctc
actcaggaataccagagggagtcgatgcttattgatgccccgaggaagcccagcatagac
ggcttctcttcggattcctggctggagatggaggaggaggcctgtgatcagcagcctcag
gaggaggaggagaaggacgaggagggcgagggcagggacagggcacccaaaccgcccacc
gatggctccacttcacccaccagcacgccctctgaggaccaggaggccctcgggaagaag
cccaaagcacctgccctgcgattcctcaaaaggactttgtctaatgagtcggaggaaagt
gtgaagtccaccacattggccgtagactaccccaagacccccaccggctctcccgccacg
gaggtctctgccaaatggacccatctcactgagtttgaactgaagggcctgaaagctctg
gtggagaaactggaatccctcccggagaacaagaagtgtgtccccgagggcatcgaggac
ccccaggcactcctggagggtgtgaagaacgtcctgaaggagcacgcagatgatgaccct
agtctggccatcactggggtccctgtggtgacttggccaaagaagactccaaagaaccgg
gctgtgggtcggcccaaggggaagctgggcccggcctccgcggtgaagttggccgccaac
cggacaacggcaggagctcggcggcgccggacgcgatgccgcaagtgcgaggcctgcctg
cggaccgagtgcggagagtgccacttctgcaaggacatgaagaagttcgggggccccggg
cgcatgaagcagagctgcatcatgcggcagtgcatcgcgccagtgctgccccacaccgcc
gtgtgccttgtgtgtggcgaggcggggaaggaagacacggtggaagaggaggaaggcaag
tttaacctcatgctcatggagtgctccatctgcaatgaaatcatccaccctggatgcctt
aagattaaggagtcagagggtgtggtcaacgacgagcttccaaactgctgggagtgtccg
aagtgtaaccacgccggcaagaccgggaaacaaaagcgtggccctggctttaagtacgcc
tccaacctgcccggctccctgctcaaggagcagaagatgaaccgggacaacaaggaaggg
caggaacctgccaagcggaggagtgagtgtgaggaggcgccccggcgcaggtcggatgag
cactcgaagaaggtgccgccggacggccttctgcgcagaaagtctgacgacgtgcacctg
aggaagaagcggaaatacgagaagccccaggagctgagtggacgcaagcgggcctcatcg
cttcaaacgtcccccggttcctcctctcacctctcgccgaggccccctctaggcagcagc
ctcagcccctggtggagatccagtctcacttacttccagcagcagctcaaacctggcaaa
gaagataagcttttcaggaaaaagcggcggtcctggaagaacgccgaggaccgcatggcg
ctggccaacaagcccctccggcgcttcaagcaggaacccgaggacgaactgcccgaggcg
ccccccaagaccagggagagcgaccactcccgctccagctcccccaccgcgggacccagc
accgaaggggccgagggcccggaggagaagaagaaggtgaagatgcgccggaagcggcgg
cttcccaacaaggagctgagcagggagctgagcaaggagctcaaccacgagatccagagg
acggagaacagcctggccaacgagaaccagcagcccatcaagtcggagcctgagagcgag
ggcgaggagcccaagcggcccccgggcatctgcgagcgtccccaccgcttcagcaagggg
ctcaacggcaccccccgggagctgcggcaccagctggggcccagcctgcgcagcccgccc
cgtgtcatctcccggcccccaccctccgtgtccccgcccaagtgtatccagatggagcgc
catgtgatccggccaccccccatcagccccccgcctgactcgctacccctggacgatggg
gcagcccacgtcatgcacagggaggtgtggatggccgtcttcagctacctcagccaccaa
gacctgtgtgtgtgcatgcgggtctgcaggacctggaaccgctggtgctgcgataagcgg
ttgtggacccgcattgacctgaaccactgcaagtctatcacacccctgatgctgagtggc
atcatccggcgacagcccgtctccctcgacctcagctggaccaatatctccaagaagcag
ctgagctggctcatcaaccggctgcctgggctccgggacttggtgctgtcaggctgctca
tggatcgcggtctcggccctttgcagctccagttgtccgctgctccggaccctggatgtc
cagtgggtggagggactaaaggatgcccagatgcgggatctcctgtccccgcccacagac
aacaggccaggtcagatggacaatcggagcaagctccggaacatcgtggagctgcgcctg
gcaggcctggacatcacagatgcctccctgcggctcatcatccgccacatgcccctgctc
tccaagctccacctcagttactgtaaccacgtcaccgaccagtctatcaacctgctcact
gctgttggcaccaccacccgagactccttaaccgagatcaacctgtctgactgcaataag
gtcactgatcagtgcctgtccttcttcaaacgctgtggaaacatctgtcatattgacctg
aggtactgcaagcaagtcaccaaggaaggctgtgagcagttcatagccgagatgtctgtg
agtgtccagtttgggcaagtagaagaaaaactcctgcaaaaactgagttag
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integrated database retrieval system
