KEGG   Homo sapiens (human): 84876
Entry
84876             CDS       T01001                                 
Symbol
ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A
Name
(RefSeq) ORAI calcium release-activated calcium modulator 1
  KO
K16056  calcium release-activated calcium channel protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04611  Platelet activation
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
hsa05340  Primary immunodeficiency
Network
nt06528  Calcium signaling
  Element
N01643  Ca2+ entry, Store-operated Ca2+ channel
Disease
H00093  Combined immunodeficiency
H02258  Tubular aggregate myopathy
Drug target
Zegocractin: D13009
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    84876 (ORAI1)
   04024 cAMP signaling pathway
    84876 (ORAI1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    84876 (ORAI1)
  09152 Endocrine system
   04924 Renin secretion
    84876 (ORAI1)
   04925 Aldosterone synthesis and secretion
    84876 (ORAI1)
   04927 Cortisol synthesis and secretion
    84876 (ORAI1)
 09160 Human Diseases
  09163 Immune disease
   05340 Primary immunodeficiency
    84876 (ORAI1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    84876 (ORAI1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    84876 (ORAI1)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   84876 (ORAI1)
SSDB
Motif
Pfam: Orai-1 DUF4153
Other DBs
NCBI-GeneID: 84876
NCBI-ProteinID: NP_116179
OMIM: 610277
HGNC: 25896
Ensembl: ENSG00000276045
UniProt: Q96D31
Structure
LinkDB
Position
12:121626530..121643109
AA seq 301 aa
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
NT seq 906 nt   +upstreamnt  +downstreamnt
atgcatccggagcccgccccgcccccgagccgcagcagtcccgagcttcccccaagcggc
ggcagcaccaccagcggcagccgccggagccgccgccgcagcggggacggggagcccccg
ggggccccgccaccgccgccgtccgccgtcacctacccggactggatcggccagagttac
tccgaggtgatgagcctcaacgagcactccatgcaggcgctgtcctggcgcaagctctac
ttgagccgcgccaagcttaaagcctccagccggacctcggctctgctctccggcttcgcc
atggtggcaatggtggaggtgcagctggacgctgaccacgactacccaccggggctgctc
atcgccttcagtgcctgcaccacagtgctggtggctgtgcacctgtttgcgctcatgatc
agcacctgcatcctgcccaacatcgaggcggtgagcaacgtgcacaatctcaactcggtc
aaggagtccccccatgagcgcatgcaccgccacatcgagctggcctgggccttctccacc
gtcatcggcacgctgctcttcctagctgaggtggtgctgctctgctgggtcaagttcttg
cccctcaagaagcagccaggccagccaaggcccaccagcaagccccccgccagtggcgca
gcagccaacgtcagcaccagcggcatcaccccgggccaggcagctgccatcgcctcgacc
accatcatggtgcccttcggcctgatctttatcgtcttcgccgtccacttctaccgctca
ctggttagccataagactgaccgacagttccaggagctcaacgagctggcggagtttgcc
cgcttacaggaccagctggaccacagaggggaccaccccctgacgcccggcagccactat
gcctag

KEGG   Homo sapiens (human): 80228
Entry
80228             CDS       T01001                                 
Symbol
ORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B
Name
(RefSeq) ORAI calcium release-activated calcium modulator 2
  KO
K16057  calcium release-activated calcium channel protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
Network
nt06528  Calcium signaling
  Element
N01643  Ca2+ entry, Store-operated Ca2+ channel
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    80228 (ORAI2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    80228 (ORAI2)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   80228 (ORAI2)
SSDB
Motif
Pfam: Orai-1 CopD MFS_1 DUF4199
Other DBs
NCBI-GeneID: 80228
NCBI-ProteinID: NP_001119812
OMIM: 610929
HGNC: 21667
Ensembl: ENSG00000160991
UniProt: Q96SN7
LinkDB
Position
7:102433575..102456825
AA seq 254 aa
MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKL
KASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILP
NVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARR
QPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKL
KVQLDGHERSLQVL
NT seq 765 nt   +upstreamnt  +downstreamnt
atgagtgctgagcttaacgtgcctatcgacccctctgctcctgcctgccctgagcccggc
cataagggcatggattaccgggactgggtccgccgcagctacctggaactggtcacctct
aaccaccactcggtacaggccctgtcgtggcggaagctctacctgagcagggccaagctg
aaggcctccagcaggacctccgccctcctctccggctttgccatggtggccatggtggag
gtgcagctggagacgcagtaccagtacccgcggccgctgctgattgccttcagcgcctgc
accacggtgctggtggccgtgcacctgttcgccctcctcatcagcacctgcatcctgccc
aatgtggaggccgtgagcaacatccacaacctgaactccatcagcgagtccccgcatgag
cgcatgcacccctacatcgagctggcctggggcttctccaccgtgcttggcatcctactc
ttcctggccgaggtggtgctgctctgctggatcaagttcctccccgtggatgcccggcgc
cagcctggccccccacctggccctgggagtcacacgggctggcaggccgccctggtgtcc
accatcatcatggtgcccgtgggcctcatcttcgtggtcttcaccatccacttctaccgc
tccctggtgcgccacaaaacggagcgccacaaccgcgagatcgaggagctccacaagctc
aaggtccagctggacgggcatgagcgcagcctgcaggtcttgtga

KEGG   Homo sapiens (human): 93129
Entry
93129             CDS       T01001                                 
Symbol
ORAI3, TMEM142C
Name
(RefSeq) ORAI calcium release-activated calcium modulator 3
  KO
K16058  calcium release-activated calcium channel protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
Network
nt06528  Calcium signaling
  Element
N01643  Ca2+ entry, Store-operated Ca2+ channel
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    93129 (ORAI3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    93129 (ORAI3)
Ion channels [BR:hsa04040]
 Other channels
  Calcium channel, calcium release-activated (Orai)
   93129 (ORAI3)
SSDB
Motif
Pfam: Orai-1
Other DBs
NCBI-GeneID: 93129
NCBI-ProteinID: NP_689501
OMIM: 610930
HGNC: 28185
Ensembl: ENSG00000175938
UniProt: Q9BRQ5
LinkDB
Position
16:30949068..30954938
AA seq 295 aa
MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAK
LKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLL
PHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAP
LDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGP
GWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV
NT seq 888 nt   +upstreamnt  +downstreamnt
atgaagggcggcgagggggacgcgggcgagcaggccccgctgaaccctgagggcgagagc
cctgcaggctcggccacgtaccgggagttcgtgcaccgcggctacctggacctcatgggg
gccagtcagcactcgctgcgggcgctcagctggcgccgcctctacctcagccgggccaag
ctcaaagcttccagccgcacgtctgccttgctctcgggcttcgccatggtggccatggtg
gaggtgcagctggagagtgaccacgagtacccaccaggcctgctggtggccttcagtgcc
tgcaccaccgtgctggtggctgtgcacctctttgcactcatggtctccacgtgtctgctg
ccccacattgaagctgtgagcaacatccacaacctcaactctgtccaccagtcgccacac
cagagactgcaccgctacgtggagctggcctggggcttctccactgccctgggcaccttt
ctcttccttgctgaagttgtcctggttggttgggtcaagtttgtgcccattggggctccc
ttggacacaccgacccccatggtgcccacatcccgggtgcccgggactctggcaccagtg
gctacctcccttagtccagcttccaatctcccacggtcctctgcgtctgcagcaccgtcc
caagctgagccagcctgcccaccccggcaagcctgtggtggtggtggggcccatgggcca
ggctggcaagcagccatggcctccacagccatcatggtacccgtggggctcgtgtttgtg
gcctttgccctgcatttctaccgctccttggtggcacacaagacagaccgctacaagcag
gaactagaggaactgaatcgcctgcagggggagctgcaggctgtgtga

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