Homo sapiens (human): 84894
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Entry
84894 CDS
T01001
Symbol
LINGO1, LERN1, LRRN6A, MRT64, UNQ201
Name
(RefSeq) leucine rich repeat and Ig domain containing 1
KO
K23533
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
Organism
hsa
Homo sapiens (human)
Disease
H00768
Autosomal recessive intellectual developmental disorder
Drug target
Opicinumab:
D11767
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
84894 (LINGO1)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Lipid raft mediated endocytosis
RhoA-dependent endocytosis
84894 (LINGO1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
LRR_8
LRR_5
LRR_4
I-set
Ig_3
ig
Ig_2
LRR_9
LRR_Zer-1
LRRNT
V-set
Motif
Other DBs
NCBI-GeneID:
84894
NCBI-ProteinID:
NP_116197
OMIM:
609791
HGNC:
21205
Ensembl:
ENSG00000169783
UniProt:
Q96FE5
Structure
PDB
PDBj
LinkDB
All DBs
Position
15:complement(77613027..77820900)
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AA seq
620 aa
AA seq
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MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRK
RFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFN
LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLV
YISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYR
LKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIS
TIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGN
LETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFT
CRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDG
TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGE
ANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPR
KSDAGISSADAPRKFNMKMI
NT seq
1863 nt
NT seq
+upstream
nt +downstream
nt
atgcaggtgagcaagaggatgctggcggggggcgtgaggagcatgcccagccccctcctg
gcctgctggcagcccatcctcctgctggtgctgggctcagtgctgtcaggctcggccacg
ggctgcccgccccgctgcgagtgctccgcccaggaccgcgctgtgctgtgccaccgcaag
cgctttgtggcagtccccgagggcatccccaccgagacgcgcctgctggacctaggcaag
aaccgcatcaaaacgctcaaccaggacgagttcgccagcttcccgcacctggaggagctg
gagctcaacgagaacatcgtgagcgccgtggagcccggcgccttcaacaacctcttcaac
ctccggacgctgggtctccgcagcaaccgcctgaagctcatcccgctaggcgtcttcact
ggcctcagcaacctgaccaagctggacatcagcgagaacaagatcgttatcctactggac
tacatgtttcaggacctgtacaacctcaagtcactggaggttggcgacaatgacctcgtc
tacatctctcaccgcgccttcagcggcctcaacagcctggagcagctgacgctggagaaa
tgcaacctgacctccatccccaccgaggcgctgtcccacctgcacggcctcatcgtcctg
aggctccggcacctcaacatcaatgccatccgggactactccttcaagaggctgtaccga
ctcaaggtcttggagatctcccactggccctacttggacaccatgacacccaactgcctc
tacggcctcaacctgacgtccctgtccatcacacactgcaatctgaccgctgtgccctac
ctggccgtccgccacctagtctatctccgcttcctcaacctctcctacaaccccatcagc
accattgagggctccatgttgcatgagctgctccggctgcaggagatccagctggtgggc
gggcagctggccgtggtggagccctatgccttccgcggcctcaactacctgcgcgtgctc
aatgtctctggcaaccagctgaccacactggaggaatcagtcttccactcggtgggcaac
ctggagacactcatcctggactccaacccgctggcctgcgactgtcggctcctgtgggtg
ttccggcgccgctggcggctcaacttcaaccggcagcagcccacgtgcgccacgcccgag
tttgtccagggcaaggagttcaaggacttccctgatgtgctactgcccaactacttcacc
tgccgccgcgcccgcatccgggaccgcaaggcccagcaggtgtttgtggacgagggccac
acggtgcagtttgtgtgccgggccgatggcgacccgccgcccgccatcctctggctctca
ccccgaaagcacctggtctcagccaagagcaatgggcggctcacagtcttccctgatggc
acgctggaggtgcgctacgcccaggtacaggacaacggcacgtacctgtgcatcgcggcc
aacgcgggcggcaacgactccatgcccgcccacctgcatgtgcgcagctactcgcccgac
tggccccatcagcccaacaagaccttcgctttcatctccaaccagccgggcgagggagag
gccaacagcacccgcgccactgtgcctttccccttcgacatcaagaccctcatcatcgcc
accaccatgggcttcatctctttcctgggcgtcgtcctcttctgcctggtgctgctgttt
ctctggagccggggcaagggcaacacaaagcacaacatcgagatcgagtatgtgccccga
aagtcggacgcaggcatcagctccgccgacgcgccccgcaagttcaacatgaagatgata
tga
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