Homo sapiens (human): 8659
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Entry
8659 CDS
T01001
Symbol
ALDH4A1, ALDH4, P5CD, P5CDh
Name
(RefSeq) aldehyde dehydrogenase 4 family member A1
KO
K00294
1-pyrroline-5-carboxylate dehydrogenase [EC:
1.2.1.88
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00250
Alanine, aspartate and glutamate metabolism
hsa00330
Arginine and proline metabolism
hsa01100
Metabolic pathways
Module
hsa_M00970
Proline degradation, proline => glutamate
Network
nt06033
Glycine, serine and arginine metabolism
Element
N01622
Proline degradation
Disease
H00190
Hyperprolinemia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00250 Alanine, aspartate and glutamate metabolism
8659 (ALDH4A1)
00330 Arginine and proline metabolism
8659 (ALDH4A1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.1 With NAD+ or NADP+ as acceptor
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
8659 (ALDH4A1)
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Motif
Pfam:
Aldedh
Motif
Other DBs
NCBI-GeneID:
8659
NCBI-ProteinID:
NP_003739
OMIM:
606811
HGNC:
406
Ensembl:
ENSG00000159423
UniProt:
P30038
A0A024RAC7
Structure
PDB
PDBj
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Position
1:complement(18871430..18902555)
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AA seq
563 aa
AA seq
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MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGR
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
WTSPQVIKETHKPLGDWSYAYMQ
NT seq
1692 nt
NT seq
+upstream
nt +downstream
nt
atgctgctgccggcgcccgcgctccgccgcgccctgctgtcccgcccctggaccggggcc
ggcctgcggtggaagcacacctcctccctgaaggtggccaacgagcccgtcttagccttc
acgcagggcagccctgagcgagatgccctgcaaaaggccttgaaggacctgaagggccgg
atggaagccatcccatgcgtggtgggggatgaggaggtgtggacgtcggacgtgcagtac
caagtgtcgccttttaaccatggacataaggtggccaagttctgttatgcagacaagagc
ctgctcaacaaagccattgaggctgccctggctgcccggaaagagtgggacctgaagcct
attgcagaccgggcccagatcttcctgaaggcggcagacatgctgagtgggccgcgcagg
gctgagatcctcgccaagaccatggtgggacagggtaagaccgtgatccaagcggagatt
gacgctgcagcggaactcatcgacttcttccggttcaatgccaagtatgcggtggagctg
gaggggcagcagcccatcagcgtgcccccgagcaccaacagcacggtgtaccggggtctg
gagggcttcgtggcggccatctcgccctttaacttcactgcaatcggcggcaacctggcg
ggggcaccggccctgatgggcaacgtggtcctatggaagcccagtgacactgccatgctg
gccagctatgctgtctaccgcatccttcgggaggctggcctgccccccaacatcatccag
tttgtgccagctgatgggcccctatttggggacactgtcaccagctcagagcacctctgt
ggcatcaacttcacaggcagtgtgcccaccttcaaacacctgtggaagcaggtggcccag
aacctggaccggttccacaccttcccacgcctggctggagagtgcggcggaaagaacttc
cacttcgtgcaccgctcggccgacgtggagagcgtggtgagcgggaccctccgctcagcc
ttcgagtacggtggccagaagtgttccgcgtgctcgcgtctctacgtgccgcactcgctg
tggccgcagatcaaagggcggctgctggaggagcacagtcggatcaaagtgggcgaccct
gcagaggattttgggaccttcttctctgcagtgattgatgccaagtcctttgcccgtatc
aagaagtggctggagcacgcacgctcctcacccagcctcaccatcctggccgggggcaag
tgtgatgactccgtgggctactttgtggagccctgcatcgtggagagcaaggaccctcag
gagcccatcatgaaggaggagatcttcgggcctgtactgtctgtgtacgtctacccggat
gacaagtacaaggagacgctgcagctggttgacagcaccaccagctatggcctcacgggg
gcagtgttctcccaggataaggacgtcgtgcaggaggccacaaaggtgctgaggaatgct
gccggcaacttctacatcaacgacaagtccactggctcgatagtgggccagcagcccttt
gggggggcccgagcctctggaaccaatgacaagccagggggcccacactacatcctgcgc
tggacgtcgccgcaggtcatcaaggagacacataagcccctgggggactggagctacgcg
tacatgcagtga
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