KEGG T01001: 8743

Homo sapiens (human): 8743

Entry

8743              CDS       T01001

Symbol

TNFSF10, APO2L, Apo-2L, CD253, TANCR, TL2, TNLG6A, TRAIL

Name

(RefSeq) TNF superfamily member 10

K04721

tumor necrosis factor ligand superfamily member 10

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04061

Viral protein interaction with cytokine and cytokine receptor

hsa04068

FoxO signaling pathway

hsa04210

Apoptosis

hsa04217

Necroptosis

hsa04650

Natural killer cell mediated cytotoxicity

hsa05130

Pathogenic Escherichia coli infection

hsa05132

Salmonella infection

hsa05164

Influenza A

hsa05417

Lipid and atherosclerosis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06231  Apoptosis (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
nt06527  Necroptosis

Element

N00146

Crosstalk between extrinsic and intrinsic apoptotic pathways

N01631

TNFSF10-RIPK1/3 signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    8743 (TNFSF10)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    8743 (TNFSF10)
   04061 Viral protein interaction with cytokine and cytokine receptor
    8743 (TNFSF10)
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    8743 (TNFSF10)
   04217 Necroptosis
    8743 (TNFSF10)
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    8743 (TNFSF10)
09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    8743 (TNFSF10)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    8743 (TNFSF10)
   05132 Salmonella infection
    8743 (TNFSF10)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    8743 (TNFSF10)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8743 (TNFSF10)
   04052 Cytokines and neuropeptides [BR:hsa04052]
    8743 (TNFSF10)
   04090 CD molecules [BR:hsa04090]
    8743 (TNFSF10)
Exosome [BR:hsa04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   8743 (TNFSF10)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Tumor necrosis fators
   8743 (TNFSF10)
CD molecules [BR:hsa04090]
Proteins
  8743 (TNFSF10)

SSDB

Motif

Pfam:

TNF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

3:complement(172505508..172523430)

AA seq 281 aa
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

NT seq 846 nt +upstreamnt +downstreamnt
atggctatgatggaggtccaggggggacccagcctgggacagacctgcgtgctgatcgtg
atcttcacagtgctcctgcagtctctctgtgtggctgtaacttacgtgtactttaccaac
gagctgaagcagatgcaggacaagtactccaaaagtggcattgcttgtttcttaaaagaa
gatgacagttattgggaccccaatgacgaagagagtatgaacagcccctgctggcaagtc
aagtggcaactccgtcagctcgttagaaagatgattttgagaacctctgaggaaaccatt
tctacagttcaagaaaagcaacaaaatatttctcccctagtgagagaaagaggtcctcag
agagtagcagctcacataactgggaccagaggaagaagcaacacattgtcttctccaaac
tccaagaatgaaaaggctctgggccgcaaaataaactcctgggaatcatcaaggagtggg
cattcattcctgagcaacttgcacttgaggaatggtgaactggtcatccatgaaaaaggg
ttttactacatctattcccaaacatactttcgatttcaggaggaaataaaagaaaacaca
aagaacgacaaacaaatggtccaatatatttacaaatacacaagttatcctgaccctata
ttgttgatgaaaagtgctagaaatagttgttggtctaaagatgcagaatatggactctat
tccatctatcaagggggaatatttgagcttaaggaaaatgacagaatttttgtttctgta
acaaatgagcacttgatagacatggaccatgaagccagtttttttggggcctttttagtt
ggctaa

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