KEGG   NETWORK: N00146
Entry
N00146                      Network                                
Name
Crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
(FASLG,TNFSF10) -> (FAS,TNFRSF10B) -> FADD -> (CASP8,CASP10) -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
(356,8743) -> (355,8795) -> 8772 -> (841,843) -> 637 -> (581,578) -> 54205 == 317 -> 842 -> (836,840)
Class
nt06524 Apoptosis
nt06263 Hepatocellular carcinoma
nt06231 Apoptosis (cancer)
nt06460 Alzheimer disease
nt06466 Pathways of neurodegeneration
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06162 Hepatitis B virus (HBV)
nt06163 Hepatitis C virus (HCV)
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165 Epstein-Barr virus (EBV)
Type
Reference
Pathway
hsa04210  Apoptosis
Gene
356  FASLG; Fas ligand
8743  TNFSF10; TNF superfamily member 10
355  FAS; Fas cell surface death receptor
8795  TNFRSF10B; TNF receptor superfamily member 10b
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
843  CASP10; caspase 10
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Reference
PMID:21697901
  Authors
Vucic D, Dixit VM, Wertz IE
  Title
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
  Journal
Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:20683470
  Authors
Tait SW, Green DR
  Title
Mitochondria and cell death: outer membrane permeabilization and beyond.
  Journal
Nat Rev Mol Cell Biol 11:621-32 (2010)
DOI:10.1038/nrm2952
Reference
PMID:24685981
  Authors
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T
  Title
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment.
  Journal
Mutat Res 768:84-97 (2014)
DOI:10.1016/j.mrfmmm.2014.03.005
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