Homo sapiens (human): 875 Help Entry 875               CDS       T01001                                  Symbol CBS, CBSL, HIP4 Name (RefSeq) cystathionine beta-synthase   KO K01697   cystathionine beta-synthase [EC:4.2.1.22] Organism hsa  Homo sapiens (human) Pathway hsa00260   Glycine, serine and threonine metabolism hsa00270   Cysteine and methionine metabolism hsa00670   One carbon pool by folate hsa01100   Metabolic pathways hsa01230   Biosynthesis of amino acids Module hsa_M00035   Methionine degradation hsa_M00338   Cysteine biosynthesis, homocysteine + serine => cysteine Network nt06030  Methionine metabolism   Element N01628   Cysteine biosynthesis Disease H00183   Homocystinuria Drug target Pegtibatinase:  D12197 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00260 Glycine, serine and threonine metabolism     875 (CBS)    00270 Cysteine and methionine metabolism     875 (CBS)   09108 Metabolism of cofactors and vitamins    00670 One carbon pool by folate     875 (CBS) Enzymes [BR:hsa01000]  4. Lyases   4.2  Carbon-oxygen lyases    4.2.1  Hydro-lyases     4.2.1.22  cystathionine beta-synthase      875 (CBS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PALP CBS DUF5380 Motif Other DBs NCBI-GeneID:  875 NCBI-ProteinID:  NP_000062 OMIM:  613381 HGNC:  1550 Ensembl:  ENSG00000160200 UniProt:  P35520 Q9NTF0 Structure PDBPDBj LinkDB All DBs Position 21:complement(43053191..43076873) Genome browser AA seq 551 aa AA seqDB search MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL NFVAAQERDQK NT seq 1656 nt NT seq  +upstreamnt  +downstreamnt atgccttctgagaccccccaggcagaagtggggcccacaggctgcccccaccgctcaggg ccacactcggcgaaggggagcctggagaaggggtccccagaggataaggaagccaaggag cccctgtggatccggcccgatgctccgagcaggtgcacctggcagctgggccggcctgcc tccgagtccccacatcaccacactgccccggcaaaatctccaaaaatcttgccagatatt ctgaagaaaatcggggacacccctatggtcagaatcaacaagattgggaagaagttcggc ctgaagtgtgagctcttggccaagtgtgagttcttcaacgcgggcgggagcgtgaaggac cgcatcagcctgcggatgattgaggatgctgagcgcgacgggacgctgaagcccggggac acgattatcgagccgacatccgggaacaccgggatcgggctggccctggctgcggcagtg aggggctatcgctgcatcatcgtgatgccagagaagatgagctccgagaaggtggacgtg ctgcgggcactgggggctgagattgtgaggacgcccaccaatgccaggttcgactccccg gagtcacacgtgggggtggcctggcggctgaagaacgaaatccccaattctcacatccta gaccagtaccgcaacgccagcaaccccctggctcactacgacaccaccgctgatgagatc ctgcagcagtgtgatgggaagctggacatgctggtggcttcagtgggcacgggcggcacc atcacgggcattgccaggaagctgaaggagaagtgtcctggatgcaggatcattggggtg gatcccgaagggtccatcctcgcagagccggaggagctgaaccagacggagcagacaacc tacgaggtggaagggatcggctacgacttcatccccacggtgctggacaggacggtggtg gacaagtggttcaagagcaacgatgaggaggcgttcacctttgcccgcatgctgatcgcg caagaggggctgctgtgcggtggcagtgctggcagcacggtggcggtggccgtgaaggcc gcgcaggagctgcaggagggccagcgctgcgtggtcattctgcccgactcagtgcggaac tacatgaccaagttcctgagcgacaggtggatgctgcagaagggctttctgaaggaggag gacctcacggagaagaagccctggtggtggcacctccgtgttcaggagctgggcctgtca gccccgctgaccgtgctcccgaccatcacctgtgggcacaccatcgagatcctccgggag aagggcttcgaccaggcgcccgtggtggatgaggcgggggtaatcctgggaatggtgacg cttgggaacatgctctcgtccctgcttgccgggaaggtgcagccgtcagaccaagttggc aaagtcatctacaagcagttcaaacagatccgcctcacggacacgctgggcaggctctcg cacatcctggagatggaccacttcgccctggtggtgcacgagcagatccagtaccacagc accgggaagtccagtcagcggcagatggtgttcggggtggtcaccgccattgacttgctg aacttcgtggccgcccaggagcgggaccagaagtga

Homo sapiens (human): 102724560 Help Entry 102724560         CDS       T01001                                  Symbol CBS, CBSL Name (RefSeq) cystathionine beta-synthase like   KO K01697   cystathionine beta-synthase [EC:4.2.1.22] Organism hsa  Homo sapiens (human) Pathway hsa00260   Glycine, serine and threonine metabolism hsa00270   Cysteine and methionine metabolism hsa00670   One carbon pool by folate hsa01100   Metabolic pathways hsa01230   Biosynthesis of amino acids Module hsa_M00035   Methionine degradation hsa_M00338   Cysteine biosynthesis, homocysteine + serine => cysteine Network nt06030  Methionine metabolism   Element N01628   Cysteine biosynthesis Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00260 Glycine, serine and threonine metabolism     102724560 (CBS)    00270 Cysteine and methionine metabolism     102724560 (CBS)   09108 Metabolism of cofactors and vitamins    00670 One carbon pool by folate     102724560 (CBS) Enzymes [BR:hsa01000]  4. Lyases   4.2  Carbon-oxygen lyases    4.2.1  Hydro-lyases     4.2.1.22  cystathionine beta-synthase      102724560 (CBS) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PALP CBS DUF5380 Motif Other DBs NCBI-GeneID:  102724560 NCBI-ProteinID:  NP_001308002 Ensembl:  ENSG00000274276 UniProt:  P35520 Structure PDBPDBj LinkDB All DBs Position 21:complement(6444869..6468621) Genome browser AA seq 551 aa AA seqDB search MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL NFVAAQERDQK NT seq 1656 nt NT seq  +upstreamnt  +downstreamnt atgccttctgagaccccccaggcagaagtggggcccacaggctgcccccaccgctcaggg ccacactcggcgaaggggagcctggagaaggggtccccagaggataaggaagccaaggag cccctgtggatccggcccgatgctccgagcaggtgcacctggcagctgggccggcctgcc tccgagtccccacatcaccacactgccccggcaaaatctccaaaaatcttgccagatatt ctgaagaaaatcggggacacccctatggtcagaatcaacaagattgggaagaagttcggc ctgaagtgtgagctcttggccaagtgtgagttcttcaacgcgggcgggagcgtgaaggac cgcatcagcctgcggatgattgaggatgctgagcgcgacgggacgctgaagcccggggac acgattatcgagccgacatccgggaacaccgggatcgggctggccctggctgcggcagtg aggggctatcgctgcatcatcgtgatgccagagaagatgagctccgagaaggtggacgtg ctgcgggcactgggggctgagattgtgaggacgcccaccaatgccaggttcgactccccg gagtcacacgtgggggtggcctggcggctgaagaacgaaatccccaattctcacatccta gaccagtaccgcaacgccagcaaccccctggctcactatgacaccaccgctgatgagatc ctgcagcagtgtgatgggaagctggacatgctggtggcttcagtgggcacgggcggcacc atcacgggcattgccaggaagctgaaggagaagtgtcctggatgcaggatcattggggtg gatcccgaagggtccatcctcgcagagccggaggagctgaaccagacggagcagacaacc tacgaggtggaagggatcggctacgacttcatccccacggtgctggacaggacggtggtg gacaagtggttcaagagcaacgatgaggaggcgttcacctttgcccgcatgctgatcgcg caagaggggctgctgtgcggtggcagtgctggcagcacggtggcggtggccgtgaaggcc gcgcaggagctgcaggagggccagcgctgcgtggtcattctgcccgactcagtgcggaac tacatgaccaagttcctgagcgacaggtggatgctgcagaagggctttctgaaggaggag gacctcacggagaagaagccctggtggtggcacctccgtgttcaggagctgggcctgtca gccccgctgaccgtgctcccgaccatcacctgtgggcacaccatcgagatcctccgggag aagggcttcgaccaggcgcccgtggtggatgaggcgggggtaatcctgggaatggtgacg cttgggaacatgctctcgtccctgcttgccgggaaggtgcagccgtcagaccaagttggc aaagtcatctacaagcagttcaaacagatccgcctcacggacacgctgggcaggctctcg cacatcctggagatggaccacttcgccctggtggtgcacgagcagatccagtaccacagc accgggaagtccagtcagcggcagatggtgttcggggtggtcaccgccattgacttgctg aacttcgtggccgcccaggagcgggaccagaagtga

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