Homo sapiens (human): 8797
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Entry
8797 CDS
T01001
Symbol
TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1
Name
(RefSeq) TNF receptor superfamily member 10a
KO
K04722
tumor necrosis factor receptor superfamily member 10A/B
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04061
Viral protein interaction with cytokine and cytokine receptor
hsa04115
p53 signaling pathway
hsa04210
Apoptosis
hsa04217
Necroptosis
hsa04650
Natural killer cell mediated cytotoxicity
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05164
Influenza A
hsa05417
Lipid and atherosclerosis
Network
nt06527
Necroptosis
Element
N01631
TNFSF10-RIPK1/3 signaling pathway
Drug target
Mapatumumab:
D04858
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09133 Signaling molecules and interaction
04061 Viral protein interaction with cytokine and cytokine receptor
8797 (TNFRSF10A)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
8797 (TNFRSF10A)
09160 Human Diseases
09172 Infectious disease: viral
05164 Influenza A
8797 (TNFRSF10A)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
8797 (TNFRSF10A)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
8797 (TNFRSF10A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04050 Cytokine receptors [BR:
hsa04050
]
8797 (TNFRSF10A)
04090 CD molecules [BR:
hsa04090
]
8797 (TNFRSF10A)
Cytokine receptors [BR:
hsa04050
]
Tumor necrosis factor receptors
TNF receptor superfamily
8797 (TNFRSF10A)
CD molecules [BR:
hsa04090
]
Proteins
8797 (TNFRSF10A)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Death
TNFR_c6
DUF6721
CR_prot_dom_plant
Motif
Other DBs
NCBI-GeneID:
8797
NCBI-ProteinID:
NP_003835
OMIM:
603611
HGNC:
11904
Ensembl:
ENSG00000104689
UniProt:
O00220
Structure
PDB
PDBj
LinkDB
All DBs
Position
8:complement(23190452..23225102)
Genome browser
AA seq
468 aa
AA seq
DB search
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMG
QHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGT
QQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPC
TTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNI
WVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEIL
SNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADP
TETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTG
RNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
NT seq
1407 nt
NT seq
+upstream
nt +downstream
nt
atggcgccaccaccagctagagtacatctaggtgcgttcctggcagtgactccgaatccc
gggagcgcagcgagtgggacagaggcagccgcggccacacccagcaaagtgtggggctct
tccgcggggaggattgaaccacgaggcgggggccgaggagcgctccctacctccatggga
cagcacggacccagtgcccgggcccgggcagggcgcgccccaggacccaggccggcgcgg
gaagccagccctcggctccgggtccacaagaccttcaagtttgtcgtcgtcggggtcctg
ctgcaggtcgtacctagctcagctgcaaccatcaaacttcatgatcaatcaattggcaca
cagcaatgggaacatagccctttgggagagttgtgtccaccaggatctcatagatcagaa
catcctggagcctgtaaccggtgcacagagggtgtgggttacaccaatgcttccaacaat
ttgtttgcttgcctcccatgtacagcttgtaaatcagatgaagaagagagaagtccctgc
accacgaccaggaacacagcatgtcagtgcaaaccaggaactttccggaatgacaattct
gctgagatgtgccggaagtgcagcagagggtgccccagagggatggtcaaggtcaaggat
tgtacgccctggagtgacatcgagtgtgtccacaaagaatcaggcaatggacataatata
tgggtgattttggttgtgactttggttgttccgttgctgttggtggctgtgctgattgtc
tgttgttgcatcggctcaggttgtggaggggaccccaagtgcatggacagggtgtgtttc
tggcgcttgggtctcctacgagggcctggggctgaggacaatgctcacaacgagattctg
agcaacgcagactcgctgtccactttcgtctctgagcagcaaatggaaagccaggagccg
gcagatttgacaggtgtcactgtacagtccccaggggaggcacagtgtctgctgggaccg
gcagaagctgaagggtctcagaggaggaggctgctggttccagcaaatggtgctgacccc
actgagactctgatgctgttctttgacaagtttgcaaacatcgtgccctttgactcctgg
gaccagctcatgaggcagctggacctcacgaaaaatgagatcgatgtggtcagagctggt
acagcaggcccaggggatgccttgtatgcaatgctgatgaaatgggtcaacaaaactgga
cggaacgcctcgatccacaccctgctggatgccttggagaggatggaagagagacatgca
agagagaagattcaggacctcttggtggactctggaaagttcatctacttagaagatggc
acaggctctgccgtgtccttggagtga
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