Homo sapiens (human): 8879 Help Entry 8879              CDS       T01001                                  Symbol SGPL1, NPHS14, RENI, S1PL, SPL Name (RefSeq) sphingosine-1-phosphate lyase 1   KO K01634   sphinganine-1-phosphate aldolase [EC:4.1.2.27] Organism hsa  Homo sapiens (human) Pathway hsa00600   Sphingolipid metabolism hsa01100   Metabolic pathways hsa04071   Sphingolipid signaling pathway Module hsa_M00100   Sphingosine degradation Disease H01657   Nephrotic syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00600 Sphingolipid metabolism     8879 (SGPL1)  09130 Environmental Information Processing   09132 Signal transduction    04071 Sphingolipid signaling pathway     8879 (SGPL1) Enzymes [BR:hsa01000]  4. Lyases   4.1  Carbon-carbon lyases    4.1.2  Aldehyde-lyases     4.1.2.27  sphinganine-1-phosphate aldolase      8879 (SGPL1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pyridoxal_deC Aminotran_5 Aminotran_1_2 DegT_DnrJ_EryC1 SepSecS Cys_Met_Meta_PP Motif Other DBs NCBI-GeneID:  8879 NCBI-ProteinID:  NP_003892 OMIM:  603729 HGNC:  10817 Ensembl:  ENSG00000166224 Pharos:  O95470(Tchem) UniProt:  O95470 Structure PDBPDBj LinkDB All DBs Position 10:70815948..70881184 Genome browser AA seq 568 aa AA seqDB search MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE LSSVFLDSLYSTDTVTQGSQMNGSPKPH NT seq 1707 nt NT seq  +upstreamnt  +downstreamnt atgcctagcacagaccttctgatgttgaaggcctttgagccctacttagagattttggaa gtatactccacaaaagccaagaattatgtaaatggacattgcaccaagtatgagccctgg cagctaattgcatggagtgtcgtgtggaccctgctgatagtctggggatatgagtttgtc ttccagccagagagtttatggtcaaggtttaaaaagaaatgttttaagctcaccaggaag atgcccattattggtcgtaagattcaagacaagttgaacaagaccaaggatgatattagc aagaacatgtcattcctgaaagtggacaaagagtatgtgaaagctttaccctcccagggt ctgagctcatctgctgttttggagaaacttaaggagtacagctctatggacgccttctgg caagaggggagagcctctggaacagtgtacagtggggaggagaagctcactgagctcctt gtgaaggcttatggagattttgcatggagtaaccccctgcatccagatatcttcccagga ctacgcaagatagaggcagaaatcgtgaggatagcttgttccctgttcaatgggggacca gattcgtgtggatgtgtgacttctgggggaacagaaagcatactgatggcctgcaaagca tatcgggatctggcctttgagaaggggatcaaaactccagaaattgtggctccccaaagt gcccatgctgcatttaacaaagcagccagttactttgggatgaagattgtgcgggtccca ttgacgaagatgatggaggtggatgtgcgggcaatgagaagagctatctccaggaacact gccatgctcgtctgttctaccccacagtttcctcatggtgtaatagatcctgtccctgaa gtggccaagctggctgtcaaatacaaaataccccttcatgtcgacgcttgtctgggaggc ttcctcatcgtctttatggagaaagcaggatacccactggagcacccatttgatttccgg gtgaaaggtgtaaccagcatttcagctgacacccataagtatggctatgccccaaaaggc tcatcattggtgttgtatagtgacaagaagtacaggaactatcagttcttcgtcgataca gattggcagggtggcatctatgcttccccaaccatcgcaggctcacggcctggtggcatt agcgcagcctgttgggctgccttgatgcacttcggtgagaacggctatgttgaagctacc aaacagatcatcaaaactgctcgcttcctcaagtcagaactggaaaatatcaaaggcatc tttgtttttgggaatccccaattgtcagtcattgctctgggatcccgtgattttgacatc taccgactatcaaacctgatgactgctaaggggtggaacttgaaccagttgcagttccca cccagtattcatttctgcatcacattactacacgcccggaaacgagtagctatacaattc ctaaaggacattcgagaatctgtcactcaaatcatgaagaatcctaaagcgaagaccaca ggaatgggtgccatctatggcatggcccagacaactgttgacaggaatatggttgcagaa ttgtcctcagtcttcttggacagcttgtacagcaccgacactgtcacccagggcagccag atgaatggttctccaaaaccccactga

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