Homo sapiens (human): 8883
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Entry
8883 CDS
T01001
Symbol
NAE1, A-116A10.1, APPBP1, HPP1, NEDFIH, ula-1
Name
(RefSeq) NEDD8 activating enzyme E1 subunit 1
KO
K04532
NEDD8-activating enzyme E1 regulatory subunit
Organism
hsa
Homo sapiens (human)
Pathway
hsa05010
Alzheimer disease
Disease
H02460
Neurodevelopmental disorder with dysmorphic facies and skeletal anomalies
Drug target
Pevonedistat (
DG01832
):
D10413
D10654
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
8883 (NAE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:
hsa04121
]
8883 (NAE1)
Ubiquitin system [BR:
hsa04121
]
Ubiquitin-activating enzymes (E1)
UBL-activating enzymes
8883 (NAE1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ThiF
E1_4HB
Motif
Other DBs
NCBI-GeneID:
8883
NCBI-ProteinID:
NP_003896
OMIM:
603385
HGNC:
621
Ensembl:
ENSG00000159593
UniProt:
Q13564
Structure
PDB
LinkDB
All DBs
Position
16:complement(66802878..66830976)
Genome browser
AA seq
534 aa
AA seq
DB search
MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
NT seq
1605 nt
NT seq
+upstream
nt +downstream
nt
atggcgcagctgggaaagctgctcaaggagcagaagtacgaccggcagctgaggttgtgg
ggtgatcatgggcaagaggctttagaatctgctcatgtttgcctaataaatgcaacagcc
acaggaactgaaattcttaaaaacttggtactaccaggtattggttcgtttacaattatt
gatggaaatcaggtcagcggagaagatgctggaaacaatttcttccttcaaagaagcagt
atcggcaagaaccgagctgaagctgccatggaattcttacaagaattaaatagcgatgtc
tctggaagttttgtggaagagagtccagaaaaccttctagacaatgatccctcatttttc
tgtaggtttactgttgtagttgcaactcagcttcctgaaagcacttcactacgcttagca
gatgtcctctggaattcccagattcctcttttgatctgtaggacatatggactagttggt
tatatgaggatcattataaaagaacatccagtaatagaatctcatccagataatgcatta
gaggatctacgactagataagccatttcctgaactgagagaacattttcagtcctatgat
ttggatcatatggaaaaaaaggaccacagtcatactccatggattgtgatcatagctaaa
tatttagcacagtggtatagtgaaacaaatggacgaatacctaaaacgtataaagaaaaa
gaggacttcagagatttgattagacaaggaattctaaaaaatgaaaatggggctccagaa
gatgaagagaattttgaagaagctattaaaaatgtgaacacagcactaaatacaactcag
atcccaagcagtattgaagatatatttaatgatgatcgctgcataaatatcaccaaacag
actccatcattttggattttagctcgtgccttaaaggaatttgtggccaaagagggtcaa
ggaaatttacctgttcgaggcacaattcctgatatgattgcagattcaggcaaatatata
aaactgcaaaacgtttaccgtgaaaaagcaaagaaagatgctgccgctgtgggtaatcat
gttgccaaattgctgcagtccattggccaggcaccagagtccatttcagagaaagaatta
aaattactctgcagcaattctgcatttcttcgagtggtaagatgtcgatccttagctgaa
gaatatggtttggatacaattaacaaggatgaaattatttctagcatggacaatccagat
aatgaaatagtgttgtacttaatgttacgggctgttgatagatttcataaacaacagggt
agatatccaggagtatctaactatcaagttgaagaagatataggaaagttgaagtcttgt
ctcactggcttccttcaggaatatggtttatctgtaatggtgaaagatgattatgtccac
gaattttgccgatatggagctgctgagccacataccattgctgcattcttggggggagct
gctgctcaagaggtcatcaaaataatcaccaaacaatttgtaatttttaataatacttac
atttacagtggcatgtcacaaacttcagcaactttccagttgtag
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