KEGG   Homo sapiens (human): 8891
Entry
8891              CDS       T01001                                 
Symbol
EIF2B3, EIF-2B, EIF2Bgamma, VWM3
Name
(RefSeq) eukaryotic translation initiation factor 2B subunit gamma
  KO
K03241  translation initiation factor eIF-2B subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
  Element
N00571  PKR-eIF2alpha signaling pathway
Disease
H00869  Leukoencephalopathy with vanishing white matter
Drug target
Fosigotifator (DG03349): D13118 D13119
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    8891 (EIF2B3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03012 Translation factors [BR:hsa03012]
    8891 (EIF2B3)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-2B
    8891 (EIF2B3)
SSDB
Motif
Pfam: LbH_EIF2B NTP_transferase NTP_transf_3 Hexapep_GlmU Hexapep DUF4954 GMPPB_C Fucose_pyrophosphorylase Bactofilin CTP_transf_3
Other DBs
NCBI-GeneID: 8891
NCBI-ProteinID: NP_065098
OMIM: 606273
HGNC: 3259
Ensembl: ENSG00000070785
UniProt: Q9NR50 Q9HA31
Structure
LinkDB
Position
1:complement(44850522..44986595)
AA seq 452 aa
MEFQAVVMAVGGGSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERVGFEEVIVVTTRDVQ
KALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTDVLVLSCDLITDVALHEVVDL
FRAYDASLAMLMRKGQDSIEPVPGQKGKKKAVEQRDFIGVDSTGKRLLFMANEADLDEEL
VIKGSILQKHPRIRFHTGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQFSSA
SSQQGQEEKEEDLKKKELKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSRSQVRC
YVHIMKEGLCSRVSTLGLYMEANRQVPKLLSALCPEEPPVHSSAQIVSKHLVGVDSLIGP
ETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSVICNNAVIEKGAD
IKDCLIGSGQRIEAKAKRVNEVIVGNDQLMEI
NT seq 1359 nt   +upstreamnt  +downstreamnt
atggaatttcaagcagtagtgatggcagtaggtggaggatctcggatgacagacctaact
tccagcattcccaaacctctgcttccagttgggaacaaacctttaatttggtacccattg
aacctgcttgagcgtgttggatttgaagaagtcattgtggttacaaccagggatgttcaa
aaggctctatgtgcagaattcaagatgaaaatgaagccagatattgtgtgtattcctgat
gacgctgacatgggaactgcagattctttgcgctacatatatccaaaacttaagacagat
gtgctggtgctgagctgtgatctgataacagacgttgccttacatgaggttgtggacctg
tttagagcttatgatgcatcacttgctatgttgatgagaaaaggccaagatagcatagaa
cctgttcccggtcaaaaggggaaaaaaaaagcagtggagcagcgtgacttcattggagtg
gacagcacaggaaagaggctgctcttcatggctaatgaagcagacttggatgaagagctg
gtcattaagggatccatcctacagaagcatcctagaatacgtttccacacgggtcttgtg
gatgcccacctctactgtttgaaaaaatacatcgtggatttcctaatggaaaatgggtca
ataacttctatccggagtgaactgattccatatttagtgagaaaacagttttcctcagct
tcctcacaacagggacaagaagaaaaagaggaggatctaaagaaaaaggagctgaagtcc
ttagatatctacagttttataaaagaagccaatacactgaacctggctccctatgatgcc
tgctggaatgcctgtcgaggagacaggtgggaagacttgtccagatcacaggtgcgctgc
tatgtccacatcatgaaagaggggctctgctctcgagtgagcacactgggactctacatg
gaagcaaacagacaggtgcccaaattgctgtctgctctctgtccagaagaaccaccagtc
cattcgtcagcccagattgtcagcaaacacctggttggagttgacagcctcattgggcca
gagacacagattggagagaagtcatccattaagcgctcagtcattggctcatcctgtctc
ataaaagatagagtgactattaccaattgccttctcatgaactcagtcactgtggaggaa
ggaagcaatatccaaggcagtgtcatctgcaacaatgctgtgatcgagaagggtgcagac
atcaaggactgcttgattggaagtggccagaggattgaagccaaagctaaacgagtgaat
gaggtgatcgtggggaatgaccagctcatggagatctga

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