Homo sapiens (human): 9101
Help
Entry
9101 CDS
T01001
Symbol
USP8, HumORF8, PITA4, SPG59, UBPY
Name
(RefSeq) ubiquitin specific peptidase 8
KO
K11839
ubiquitin carboxyl-terminal hydrolase 8 [EC:
3.4.19.12
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04137
Mitophagy - animal
hsa04144
Endocytosis
hsa04934
Cushing syndrome
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00319
Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
Disease
H01102
Pituitary adenomas
H01431
Cushing syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
9101 (USP8)
04137 Mitophagy - animal
9101 (USP8)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
9101 (USP8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
9101 (USP8)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
9101 (USP8)
04121 Ubiquitin system [BR:
hsa04121
]
9101 (USP8)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.19 Omega peptidases
3.4.19.12 ubiquitinyl hydrolase 1
9101 (USP8)
Peptidases and inhibitors [BR:
hsa01002
]
Cysteine peptidases
Family C19: ubiquitin-specific protease family
9101 (USP8)
Membrane trafficking [BR:
hsa04131
]
Endosome - Lysosome transport
Others
Others
9101 (USP8)
Ubiquitin system [BR:
hsa04121
]
Deubiquitinating enzyme (DUB)
Ubiquitin-specific proteases (UBPs)
UBP/USP
9101 (USP8)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
UCH
USP8_dimer
WW_USP8
UCH_1
Rhodanese
Metallothio_Pro
HscB_4_cys
Motif
Other DBs
NCBI-GeneID:
9101
NCBI-ProteinID:
NP_001122082
OMIM:
603158
HGNC:
12631
Ensembl:
ENSG00000138592
Pharos:
P40818
(Tbio)
UniProt:
P40818
Structure
PDB
LinkDB
All DBs
Position
15:50424405..50514421
Genome browser
AA seq
1118 aa
AA seq
DB search
MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
NT seq
3357 nt
NT seq
+upstream
nt +downstream
nt
atgcctgctgtggcttcagttcctaaagaactctacctcagttcttcactaaaagacctt
aataagaagacagaagttaaaccagagaaaataagcactaagagttatgtgcacagtgcc
ctgaagatctttaagacagcagaagaatgcagattagatcgtgatgaggaaagggcctat
gtactatatatgaaatacgtgactgtttataatcttatcaaaaaaagacctgatttcaag
caacagcaggattatttccattcaatacttggacctggaaacatcaaaaaagctgtcgaa
gaagctgaaagactctctgaaagccttaaattaagatatgaagaagctgaagtccggaaa
aaacttgaggaaaaagacaggcaggaggaagcacagcggctacaacaaaaaaggcaggaa
acaggaagagaggatggtggcacattggctaaaggctctttggagaatgttttggattcc
aaagacaaaacccaaaagagcaatggtgaaaagaatgaaaaatgtgagaccaaagagaaa
ggagcaatcacagcaaaggaactatacacaatgatgacggataaaaacatcagcttgatt
ataatggatgctcgaagaatgcaggattatcaggattcctgtattttacattctctcagt
gttcctgaagaagccatcagtccaggagtcactgctagttggattgaagcacacctgcca
gatgattctaaagacacatggaagaagagggggaatgtggagtatgtggtacttcttgac
tggtttagttctgccaaagatttacagattggaacaactctccggagtctgaaagatgca
cttttcaagtgggaaagtaaaactgtcctgcgcaatgagcctttggttttagagggaggc
tatgaaaactggctcctttgttatccccagtatacaacaaatgctaaggtcactccaccc
ccacgacgccagaatgaagaggtgtctatctcattggattttacttatccctcattggaa
gaatcaattccttctaaacctgctgcccagacgccacctgcatctatagaagtagatgaa
aatatagaattgataagtggtcaaaatgagagaatgggaccactgaatatatcaactcca
gttgaaccagttgctgcttctaaatctgatgtttcacccataattcagccagtgcctagt
ataaagaatgttccacagattgatcgtactaaaaaaccagcagtcaaattgcctgaagag
catagaataaaatctgaaagtacaaaccatgagcaacaatctcctcagagtggaaaagtt
attcctgatcgttccaccaagccagtagttttttctccaactctcatgttaacagatgaa
gaaaaggctcgtattcatgcagaaactgctcttctaatggaaaaaaacaaacaagaaaaa
gaacttcgggaaaggcagcaagaggaacagaaagagaaactgaggaaggaagaacaagaa
caaaaagccaaaaagaaacaagaagctgaagaaaatgaaattacagagaagcaacaaaaa
gcaaaagaagaaatggagaagaaagaaagtgaacaggccaagaaagaagataaagaaacc
tcagcaaagaggggcaaagaaataacaggagtaaaaagacaaagtaaaagtgaacatgaa
acttctgatgccaagaaatctgtagaagatagggggaaaaggtgtccaaccccagaaata
cagaaaaagtcaacaggagatgtgccccatacatctgtgacaggggattcaggttcaggc
aagccatttaagattaaaggacaaccagaaagtggaattctaaggacaggaacttttaga
gaggatacagacgataccgaaagaaataaagctcaacgagaacctttgacaagagcacga
agtgaagaaatggggaggatcgtaccaggactgccttcaggctgggccaagtttcttgac
ccaatcactggaacctttcgttattatcattcacccaccaacactgttcatatgtaccca
ccggaaatggctccttcatctgcacctccttccacccctccaactcataaagccaagcca
cagattcctgctgagcgggatagggaaccttccaaactgaagcgctcctactcctcccca
gatataacccaggctattcaagaggaagagaagaggaagccaacagtaactccaacagtt
aatcgggaaaacaagccaacatgttatcctaaagctgagatctcaaggctttctgcttct
cagattcggaacctcaatcctgtttttggaggttctggaccagctcttactggacttcgt
aacttaggaaatacttgttatatgaactcaatattgcagtgcctatgtaacgctccacat
ttggctgattatttcaaccgaaactgttatcaggatgatattaacaggtcaaatttgttg
gggcataaaggtgaagtggcagaagaatttggtataatcatgaaagccctgtggacagga
cagtatagatatatcagtccaaaggactttaaaatcaccattgggaagatcaatgaccag
tttgcaggatacagtcagcaagattcacaagaattgcttctgttcctaatggatggtctc
catgaagatctaaataaagctgataatcggaagagatataaagaagaaaataatgatcat
ctcgatgactttaaagctgcagaacatgcctggcagaaacacaagcagctcaatgagtct
attattgttgcactttttcagggtcaattcaaatctacagtacagtgcctcacatgtcac
aaaaagtctaggacatttgaggccttcatgtatttgtctctaccactagcatccacaagt
aaatgtacattacaggattgccttagattattttccaaagaagaaaaactcacagataac
aacagattttactgcagtcattgcagagctcgacgggattctctaaaaaagatagaaatc
tggaagttaccacctgtgcttttagtgcatctgaaacgtttttcctacgatggcaggtgg
aaacaaaaattacagacatctgtggacttcccgttagaaaatcttgacttgtcacagtat
gttattggtccaaagaacaatttgaagaaatataatttgttttctgtttcaaatcactac
ggtgggctggatggaggccactacacagcctattgtaaaaatgcagcaagacaacggtgg
tttaagtttgatgatcatgaagtttctgatatctccgtttcttctgtgaaatcttcagca
gcttatatcctcttttatacttcattgggaccacgagtaactgatgtagccacataa
DBGET
integrated database retrieval system
