Homo sapiens (human): 9181
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Entry
9181 CDS
T01001
Symbol
ARHGEF2, GEF, GEF-H1, GEFH1, LFP40, Lfc, NEDMHM, P40
Name
(RefSeq) Rho/Rac guanine nucleotide exchange factor 2
KO
K12791
Rho guanine nucleotide exchange factor 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04530
Tight junction
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06180
Pathogenic Escherichia coli
Element
N01285
Microtubule-RHOA signaling pathway
Disease
H02470
Neurodevelopmental disorder with structural brain abnormalities
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
9181 (ARHGEF2)
05131 Shigellosis
9181 (ARHGEF2)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
9181 (ARHGEF2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
9181 (ARHGEF2)
Membrane trafficking [BR:
hsa04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
9181 (ARHGEF2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RhoGEF
PH_16
PH
C1_1
C1_2
Prok-RING_1
Zn_ribbon_19
PHD
Motif
Other DBs
NCBI-GeneID:
9181
NCBI-ProteinID:
NP_001155855
OMIM:
607560
HGNC:
682
Ensembl:
ENSG00000116584
UniProt:
Q92974
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:complement(155946854..155979617)
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AA seq
986 aa
AA seq
DB search
MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSI
TAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERP
SSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNM
RNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVI
YELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLER
RRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDK
RFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALG
LVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLL
WKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFL
ISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQK
DRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIR
EVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSD
SSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRA
NSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLR
ESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPP
QPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHS
PRDFTRMQDIPEETESRDGEAVASES
NT seq
2961 nt
NT seq
+upstream
nt +downstream
nt
atgtctcggatcgaatccctcacgcgggcgcggatcgaccggagcagagagctggcgagc
aagacccgggaaaaggagaagatgaaggaagccaaggatgcccgctataccaatgggcac
ctcttcaccaccatttcagtttcaggcatgaccatgtgctatgcctgtaacaagagcatc
acagccaaggaagccctcatctgcccaacctgcaatgtgactatccacaaccgctgtaaa
gacaccctcgccaactgtaccaaggtcaagcagaagcaacagaaagcggccctgctgaag
aacaacaccgccttgcagtccgtttctcttcgaagtaagacaaccatccgggagcggcca
agctcggccatctacccctccgacagcttccggcagtccctcctgggctcccgccgtggc
cgctcctccttgtctttagccaagagtgtttctaccaccaacattgctggacatttcaat
gatgagtctcccctggggctgcgccggatcctctcacagtccacagactccctcaacatg
cggaaccgaaccctatccgtggaatccctcattgacgaagcagaggtaatctacagtgag
ctgatgagtgactttgagatggatgagaaggactttgcagctgactcttggagtcttgct
gtggacagcagcttcctgcagcagcataaaaaggaggtgatgaagcagcaagatgtcatc
tatgagctaatccagacagagctgcaccatgtgaggacactgaagatcatgacccgcctc
ttccgcacggggatgctggaagagctacacttggagccaggagtggtccagggcctgttc
ccctgcgtggacgagctcagtgacatccatacacgcttcctcagccagctattagaacgc
cgacgccaggccctgtgccctggcagcacccggaactttgtcatccatcgcttgggtgat
ctgctcatcagccagttctcaggtcctagtgcggagcagatgtgtaagacctactcggag
ttctgcagccgccacagcaaggccttaaagctctataaggagctgtacgcccgagacaaa
cgcttccagcaattcatccggaaagtgacccgccccgccgtgctcaagcggcacggggta
caggagtgcatcctgctggtgactcagcgcatcaccaagtacccgttactcatcagccgc
atcctgcagcattcccacgggatcgaggaggagcgccaggacctgaccacagcactgggg
ctagtgaaggagctgctgtccaatgtggacgagggtatttatcagctggagaaaggggcc
cgtctgcaggagatctacaaccgcatggaccctcgggcccaaaccccagtgcctggcaag
ggcccctttggccgagaggaacttctgaggcgcaaactcatccacgatggctgcctgctc
tggaagacagcgacggggcgcttcaaagatgtgctagtgctgctgatgacagatgtactg
gtgtttctccaggaaaaggaccagaagtacatctttcctaccctggacaagccttcagtg
gtatcgctgcagaatctaatcgtacgagacattgccaaccaggagaaagggatgtttctg
atcagcgcagccccacctgagatgtacgaggtgcacacagcatcccgggatgaccggagc
acctggatccgggtcattcagcagagcgtgcgcacatgcccatccagggaggacttcccc
ctgattgagacagaggatgaggcttacctgcggcgaattaagatggagttgcagcagaag
gaccgggcactggtggagctgctgcgagagaaggtcgggctgtttgctgagatgacccat
ttccaggccgaagaggatggtggcagtgggatggccctgcccaccctgcccaggggcctt
ttccgctctgagtcccttgagtcccctcgtggcgagcggctgctgcaggatgccatccgt
gaggtggagggtctgaaagacctgctggtggggccaggagtggaactgctcttgacaccc
cgagagccagccctgcccttggaaccagacagcggtggtaacacgagtcctggggtcact
gccaatggtgaggccagaaccttcaatggctccattgaactctgcagagctgactcagac
tctagccagagggatcgaaatggaaatcagctgagatcaccgcaagaggaggcgttacag
cgattggtcaatctctatggacttctacatggcctacaggcagctgtggcccagcaggac
actctgatggaagcccggttccctgagggccctgagcggcgggagaagctgtgccgagcc
aactctcgggatggggaggctggcagggctggggctgcccctgtggcccctgaaaagcag
gccacggaactggcattactgcagcggcaacatgcgctgctgcaggaggagctacggcgc
tgccggcggctaggtgaagaacgggcaaccgaagctggcagcctggaggcccggctccgg
gagagtgagcaggcccgggcactgctggagcgtgaggccgaagaggctcgaaggcagctg
gccgccctgggccagaccgagccactcccagctgaggccccctgggcccgcagacctgtg
gatcctcggcggcgcagcctccccgcaggcgatgccctgtacttgagtttcaacccccca
cagcccagccgaggcactgaccgcctggatctacctgtcactactcgctctgtccatcga
aactttgaggaccgagagaggcaggaactggggagccccgaagagcggctgcaagacagc
agtgaccctgacactggcagcgaggaggaaggtagcagccgtctgtctccgccccacagt
ccacgagactttaccagaatgcaggacatcccggaggagacggagagccgcgacggggag
gctgtagcctccgagagctaa
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