KEGG   NETWORK: N01285
Entry
N01285                      Network                                
Name
Microtubule-RHOA signaling pathway
Definition
(TUBA+TUBB) -| ARHGEF2 -> RHOA -> ROCK1/2
  Expanded
((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688)) -| 9181 -> 387 -> (6093,9475)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Gene
7846  TUBA1A; tubulin alpha 1a
10376  TUBA1B; tubulin alpha 1b
84790  TUBA1C; tubulin alpha 1c
7278  TUBA3C; tubulin alpha 3c
113457  TUBA3D; tubulin alpha 3d
112714  TUBA3E; tubulin alpha 3e
7277  TUBA4A; tubulin alpha 4a
51807  TUBA8; tubulin alpha 8
203068  TUBB; tubulin beta class I
81027  TUBB1; tubulin beta 1 class VI
7280  TUBB2A; tubulin beta 2A class IIa
347733  TUBB2B; tubulin beta 2B class IIb
10381  TUBB3; tubulin beta 3 class III
10382  TUBB4A; tubulin beta 4A class IVa
10383  TUBB4B; tubulin beta 4B class IVb
84617  TUBB6; tubulin beta 6 class V
347688  TUBB8; tubulin beta 8 class VIII
9181  ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
Reference
  Authors
Krendel M, Zenke FT, Bokoch GM
  Title
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.
  Journal
Nat Cell Biol 4:294-301 (2002)
DOI:10.1038/ncb773
Reference
  Authors
Birkenfeld J, Nalbant P, Yoon SH, Bokoch GM
  Title
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?
  Journal
Trends Cell Biol 18:210-9 (2008)
DOI:10.1016/j.tcb.2008.02.006
Reference
  Authors
Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandi MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G
  Title
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
  Journal
J Cell Biol 218:3077-3097 (2019)
DOI:10.1083/jcb.201812073
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