 | | NETWORK: N01285 | |
| Entry |
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| Name |
Microtubule-RHOA signaling pathway
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| Definition |
(TUBA+TUBB) -| ARHGEF2 -> RHOA -> ROCK1/2 |
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| Expanded |
((7846,10376,84790,7278,113457,112714,7277,51807)+(203068,81027,7280,347733,10381,10382,10383,84617,347688)) -| 9181 -> 387 -> (6093,9475) |
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| Class |
nt06180 Pathogenic Escherichia coli
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| Type |
Reference
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| Gene |
| 7846 | TUBA1A; tubulin alpha 1a |
| 10376 | TUBA1B; tubulin alpha 1b |
| 84790 | TUBA1C; tubulin alpha 1c |
| 7278 | TUBA3C; tubulin alpha 3c |
| 113457 | TUBA3D; tubulin alpha 3d |
| 112714 | TUBA3E; tubulin alpha 3e |
| 7277 | TUBA4A; tubulin alpha 4a |
| 51807 | TUBA8; tubulin alpha 8 |
| 203068 | TUBB; tubulin beta class I |
| 81027 | TUBB1; tubulin beta 1 class VI |
| 7280 | TUBB2A; tubulin beta 2A class IIa |
| 347733 | TUBB2B; tubulin beta 2B class IIb |
| 10381 | TUBB3; tubulin beta 3 class III |
| 10382 | TUBB4A; tubulin beta 4A class IVa |
| 10383 | TUBB4B; tubulin beta 4B class IVb |
| 84617 | TUBB6; tubulin beta 6 class V |
| 347688 | TUBB8; tubulin beta 8 class VIII |
| 9181 | ARHGEF2; Rho/Rac guanine nucleotide exchange factor 2 |
| 387 | RHOA; ras homolog family member A |
| 6093 | ROCK1; Rho associated coiled-coil containing protein kinase 1 |
| 9475 | ROCK2; Rho associated coiled-coil containing protein kinase 2 |
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| Reference |
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| Authors |
Krendel M, Zenke FT, Bokoch GM |
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| Title |
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. |
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| Journal |
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| Reference |
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| Authors |
Birkenfeld J, Nalbant P, Yoon SH, Bokoch GM |
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| Title |
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? |
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| Journal |
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| Reference |
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| Authors |
Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandi MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G |
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| Title |
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways. |
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| Journal |
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| LinkDB |
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