Homo sapiens (human): 9517
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Entry
9517 CDS
T01001
Symbol
SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a
Name
(RefSeq) serine palmitoyltransferase long chain base subunit 2
KO
K00654
serine palmitoyltransferase [EC:
2.3.1.50
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00600
Sphingolipid metabolism
hsa01100
Metabolic pathways
hsa04071
Sphingolipid signaling pathway
hsa04382
Cornified envelope formation
Module
hsa_M00094
Ceramide biosynthesis
hsa_M00099
Sphingosine biosynthesis
Network
nt06545
Cornified envelope formation
Element
N01926
Sphinganine synthesis
Disease
H00265
Hereditary sensory and autonomic neuropathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
9517 (SPTLC2)
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
9517 (SPTLC2)
09150 Organismal Systems
09158 Development and regeneration
04382 Cornified envelope formation
9517 (SPTLC2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
9517 (SPTLC2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.50 serine C-palmitoyltransferase
9517 (SPTLC2)
Amino acid related enzymes [BR:
hsa01007
]
Aminotransferase (transaminase)
Class II
9517 (SPTLC2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Aminotran_1_2
Beta_elim_lyase
Aminotran_5
Motif
Other DBs
NCBI-GeneID:
9517
NCBI-ProteinID:
NP_004854
OMIM:
605713
HGNC:
11278
Ensembl:
ENSG00000100596
UniProt:
O15270
Structure
PDB
PDBj
LinkDB
All DBs
Position
14:complement(77505997..77616637)
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AA seq
562 aa
AA seq
DB search
MRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHVTQNGGLYKRPFN
EAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFEN
FYTRNLYMRIRDNWNRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLG
FARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFA
TNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQ
PRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVV
EYFGLDPEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQII
TSMKCIMGQDGTSLGKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIG
AFGREMLKRNIGVVVVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYS
RHRLVPLLDRPFDETTYEETED
NT seq
1689 nt
NT seq
+upstream
nt +downstream
nt
atgcggccggagcccggaggctgctgctgccgccgcacggtgcgggcgaatggctgcgtg
gcgaacggggaagtacggaacgggtacgtgaggagcagcgctgcagccgcagccgcagcc
gccgccggccagatccatcatgttacacaaaatggaggactatataaaagaccgtttaat
gaagcttttgaagaaacaccaatgctggttgctgtgctcacgtatgtggggtatggcgta
ctcaccctctttggatatcttcgagatttcttgaggtattggagaattgaaaagtgtcac
catgcaacagaaagagaagaacaaaaggactttgtgtcattgtatcaagattttgaaaac
ttttatacaaggaatctgtacatgaggataagagacaactggaatcggccaatctgtagt
gtgcctggagccagggtggacatcatggagagacagtctcatgattataactggtccttc
aagtatacagggaatataataaagggtgttataaacatgggttcctacaactatcttgga
tttgcacggaatactggatcatgtcaagaagcagccgccaaagtccttgaggagtatgga
gctggagtgtgcagtactcggcaggaaattggaaacctggacaagcatgaagaactagag
gagcttgtagcaaggttcttaggagtagaagctgctatggcgtatggcatgggatttgca
acgaattcaatgaacattcctgctcttgttggcaaaggttgcctgattctgagtgatgaa
ctgaatcatgcatcactggttctgggagccagactgtcaggagcaaccattagaatcttc
aaacacaacaatatgcaaagcctagagaagctattgaaagatgccattgtttatggtcag
cctcggacacgaaggccctggaagaaaattctcatccttgtggaaggaatatatagcatg
gagggatctattgttcgtcttcctgaagtgattgccctcaagaagaaatacaaggcatac
ttgtatctggatgaggctcacagcattggcgccctgggccccacaggccggggtgtggtg
gagtactttggcctggatcccgaggatgtggatgttatgatgggaacgttcacaaagagt
tttggtgcttctggaggatatattggaggcaagaaggagctgatagactacctgcgaaca
cattctcatagtgcagtgtatgccacgtcattgtcacctcctgtagtggagcagatcatc
acctccatgaagtgcatcatggggcaggatggcaccagccttggtaaagagtgtgtacaa
cagttagctgaaaacaccaggtatttcaggagacgcctgaaagagatgggcttcatcatc
tatggaaatgaagactctccagtagtgcctttgatgctctacatgcctgccaaaattggc
gcctttggacgggagatgctgaagcggaacatcggtgtcgttgtggttggatttcctgcc
accccaattattgagtccagagccaggttttgcctgtcagcagctcataccaaagaaata
cttgatactgctttaaaggagatagatgaagttggggacctattgcagctgaagtattcc
cgtcatcggttggtacctctactggacaggccctttgacgagacgacgtatgaagaaaca
gaagactga
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