KEGG   NETWORK: N01926
Entry
N01926                      Network                                
Name
Sphinganine synthesis
Definition
Palmitoyl-CoA -- SPT -> 3-Dehydrosphinganine -- KDSR -> Sphinganine
  Expanded
C00154 -- 10558,9517,55304 -> C02934 -- 2531 -> C00836
Class
nt06545 Cornified envelope formation
Type
Reference
Pathway
hsa04382 Cornified envelope formation   
Disease
H00710 Erythrokeratodermia variabilis   
Gene
10558  SPTLC1; serine palmitoyltransferase long chain base subunit 1
9517  SPTLC2; serine palmitoyltransferase long chain base subunit 2
55304  SPTLC3; serine palmitoyltransferase long chain base subunit 3
2531  KDSR; 3-ketodihydrosphingosine reductase
Metabolite
C00154  Palmitoyl-CoA
C02934  3-Dehydrosphinganine
C00836  Sphinganine
Reference
PMID:23954553
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
PMID:36902463
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
LinkDB

DBGET integrated database retrieval system