KEGG   Homo sapiens (human): 9775
Entry
9775              CDS       T01001                                 
Symbol
EIF4A3, DDX48, Fal1, MUK34, NMP265, NUK34, RCPS, eIF-4A-III, eIF4A-III, eIF4AIII
Name
(RefSeq) eukaryotic translation initiation factor 4A3
  KO
K13025  ATP-dependent RNA helicase [EC:5.6.2.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
Network
nt06547  Spliceosome
  Element
N01972  Spliceosome catalysis (branching)
N01993  Spliceosome catalysis (exon ligation)
N01994  Spliceosome disassembly
N01995  mRNA export to the cytoplasm
Disease
H02503  Richieri-Costa-Pereira syndrome
Drug target
Zotatifin: D11837
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    9775 (EIF4A3)
  09122 Translation
   03013 Nucleocytoplasmic transport
    9775 (EIF4A3)
   03015 mRNA surveillance pathway
    9775 (EIF4A3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    9775 (EIF4A3)
   03041 Spliceosome [BR:hsa03041]
    9775 (EIF4A3)
   03009 Ribosome biogenesis [BR:hsa03009]
    9775 (EIF4A3)
   03012 Translation factors [BR:hsa03012]
    9775 (EIF4A3)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.7  DEAD-box RNA helicase
     9775 (EIF4A3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     9775 (EIF4A3)
   mRNA cycle factors
    Stress granule specific factors
     9775 (EIF4A3)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    9775 (EIF4A3)
Ribosome biogenesis [BR:hsa03009]
 Eukaryotic type
  90S particles
   Helicases
    9775 (EIF4A3)
Translation factors [BR:hsa03012]
 Eukaryotic type
  Initiation factors
   eIF-4
    9775 (EIF4A3)
SSDB
Motif
Pfam: DEAD Helicase_C ResIII AAA_19 Cas3-like_C_2 AAA_30 AAA_22 TniB Flavi_DEAD
Other DBs
NCBI-GeneID: 9775
NCBI-ProteinID: NP_055555
OMIM: 608546
HGNC: 18683
Ensembl: ENSG00000141543
UniProt: P38919
Structure
LinkDB
Position
17:complement(80134369..80147128)
AA seq 411 aa
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
NT seq 1236 nt   +upstreamnt  +downstreamnt
atggcgaccacggccacgatggcgacctcgggctcggcgcgaaagcggctgctcaaagag
gaagacatgactaaagtggaattcgagaccagcgaggaggtggatgtgacccccacgttc
gacaccatgggcctgcgggaggacctgctgcggggcatctacgcttacggttttgaaaaa
ccatcagcaatccagcaacgagcaatcaagcagatcatcaaagggagagatgtcatcgca
cagtctcagtccggcacaggaaaaacagccaccttcagtatctcagtcctccagtgtttg
gatattcaggttcgtgaaactcaagctttgatcttggctcccacaagagagttggctgtg
cagatccagaaggggctgcttgctctcggtgactacatgaatgtccagtgccatgcctgc
attggaggcaccaatgttggcgaggacatcaggaagctggattacggacagcatgttgtc
gcgggcactccagggcgtgtttttgatatgattcgtcgcagaagcctaaggacacgtgct
atcaaaatgttggttttggatgaagctgatgaaatgttgaataaaggtttcaaagagcag
atttacgatgtatacaggtacctgcctccagccacacaggtggttctcatcagtgccacg
ctgccacacgagattctggagatgaccaacaagttcatgaccgacccaatccgcatcttg
gtgaaacgtgatgaattgactctggaaggcatcaagcaatttttcgtggcagtggagagg
gaagagtggaaatttgacactctgtgtgacctctacgacacactgaccatcactcaggcg
gtcatcttctgcaacaccaaaagaaaggtggactggctgacggagaaaatgagggaagcc
aacttcactgtatcctcaatgcatggagacatgccccagaaagagcgggagtccatcatg
aaggagttccggtcgggcgccagccgagtgcttatttctacagatgtctgggccaggggg
ttggatgtccctcaggtgtccctcatcattaactatgatctccctaataacagagaattg
tacatacacagaattgggagatcaggtcgatacggccggaagggtgtggccattaacttt
gtaaagaatgacgacatccgcatcctcagagatatcgagcagtactattccactcagatt
gatgagatgccgatgaacgttgctgatcttatctga

KEGG   Homo sapiens (human): 22794
Entry
22794             CDS       T01001                                 
Symbol
CASC3, BTZ, MLN51
Name
(RefSeq) CASC3 exon junction complex subunit
  KO
K14323  protein CASC3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
Network
nt06547  Spliceosome
  Element
N01972  Spliceosome catalysis (branching)
N01993  Spliceosome catalysis (exon ligation)
N01994  Spliceosome disassembly
N01995  mRNA export to the cytoplasm
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    22794 (CASC3)
  09122 Translation
   03013 Nucleocytoplasmic transport
    22794 (CASC3)
   03015 mRNA surveillance pathway
    22794 (CASC3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    22794 (CASC3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     22794 (CASC3)
SSDB
Motif
Pfam: Btz
Other DBs
NCBI-GeneID: 22794
NCBI-ProteinID: NP_031385
OMIM: 606504
HGNC: 17040
Ensembl: ENSG00000108349
UniProt: O15234
Structure
LinkDB
Position
17:40140537..40172171
AA seq 703 aa
MADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALH
LRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEAN
DAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPA
YIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALY
GYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRN
AAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVR
DPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKL
AEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQ
PSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHI
SIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLY
PPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQV
YGGVTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS
NT seq 2112 nt   +upstreamnt  +downstreamnt
atggcggaccggcggcggcagcgcgcttcgcaagacaccgaggacgaggaatctggtgct
tcgggctccgacagcggcggctccccgttgcggggaggcgggagctgcagcggtagcgcc
ggaggcggcggcagcggctctctgccttcacagcgcggaggccgaaccggggcccttcat
ctgcggcgggtggagagcgggggcgccaagagtgctgaggagtcggagtgtgagagtgaa
gatggcattgaaggtgatgctgttctctcggattatgaaagtgcagaagactcggaaggt
gaagaaggtgaatacagtgaagaggaaaactccaaagtggagctgaaatcagaagctaat
gatgctgttaattcttcaacaaaagaagagaagggagaagaaaagcctgacaccaaaagc
actgtgactggagagaggcaaagtggggacggacaggagagcacagagcctgtggagaac
aaagtgggtaaaaagggccctaagcatttggatgatgatgaagatcggaagaatccagca
tacatacctcggaaagggctcttctttgagcatgatcttcgagggcaaactcaggaggag
gaagtcagacccaaggggcgtcagcgaaagctatggaaggatgagggtcgctgggagcat
gacaagttccgggaagatgagcaggccccaaagtcccgacaggagctcattgctctttat
ggttatgacattcgctcagctcataatcctgatgacatcaaacctcgaagaatccggaaa
ccccgatatgggagtcctccacaaagagatccaaactggaacggtgagcggctaaacaag
tctcatcgccaccagggtcttgggggcaccctaccaccaaggacatttattaacaggaat
gctgcaggtaccggccgtatgtctgcacccaggaattattctcgatctgggggcttcaag
gaaggtcgtgctggttttaggcctgtggaagctggtgggcagcatggtggccggtctggt
gagactgttaagcatgagattagttaccggtcacggcgcctagagcagacttctgtgagg
gatccatctccagaagcagatgctccagtgcttggcagtcctgagaaggaagaggcagcc
tcagagccaccagctgctgctcctgatgctgcaccaccaccccctgataggcccattgag
aagaaatcctattcccgggcaagaagaactcgaaccaaagttggagatgcagtcaagctt
gcagaggaggtgccccctcctcctgaaggactgattccagcacctccagtcccagaaacc
accccaactccacctactaagactgggacctgggaagctccggtggattctagtacaagt
ggacttgagcaagatgtggcacaactaaatatagcagaacagaattggagtccggggcag
ccttctttcctgcaaccacgggaacttcgaggtatgcccaaccatatacacatgggagca
ggacctccacctcagtttaaccggatggaagaaatgggtgtccagggtggtcgagccaaa
cgctattcatcccagcggcaaagacctgtgccagagccccccgcccctccagtgcatatc
agtatcatggagggacattactatgatccactgcagttccagggaccaatctatacccat
ggtgacagccctgccccgctgcctccacagggcatgcttgtgcagccaggaatgaacctt
ccccacccaggtttacatccccaccagacaccagctcctctgcccaatccaggcctctat
cccccaccagtgtccatgtctccaggacagccaccacctcagcagttgcttgctcctact
tacttttctgctccaggcgtcatgaactttggtaatcccagttacccttatgctccaggg
gcactgcctcccccaccaccgcctcatctgtatcctaatacacaggccccatcacaggta
tatggaggagtgacctactataaccccgcccagcagcaggtgcagccaaagccctcccca
ccccggaggactccccagccagtcaccatcaagccccctccacctgaggttgtaagcagg
ggttccagttaa

KEGG   Homo sapiens (human): 4116
Entry
4116              CDS       T01001                                 
Symbol
MAGOH, MAGOH1, MAGOHA
Name
(RefSeq) mago homolog, exon junction complex subunit
  KO
K12877  protein mago nashi
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
Network
nt06547  Spliceosome
  Element
N01972  Spliceosome catalysis (branching)
N01993  Spliceosome catalysis (exon ligation)
N01994  Spliceosome disassembly
N01995  mRNA export to the cytoplasm
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    4116 (MAGOH)
  09122 Translation
   03013 Nucleocytoplasmic transport
    4116 (MAGOH)
   03015 mRNA surveillance pathway
    4116 (MAGOH)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    4116 (MAGOH)
   03041 Spliceosome [BR:hsa03041]
    4116 (MAGOH)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     4116 (MAGOH)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    4116 (MAGOH)
SSDB
Motif
Pfam: Mago_nashi
Other DBs
NCBI-GeneID: 4116
NCBI-ProteinID: NP_002361
OMIM: 602603
HGNC: 6815
Ensembl: ENSG00000162385
UniProt: P61326
Structure
LinkDB
Position
1:complement(53226900..53238518)
AA seq 146 aa
MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEEL
KRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLR
VFYYLVQDLKCLVFSLIGLHFKIKPI
NT seq 441 nt   +upstreamnt  +downstreamnt
atggagagtgacttttatctgcgttactacgtggggcacaagggcaagttcggccacgag
ttcctggagtttgagtttcgaccggacgggaagttaagatatgccaacaacagcaattac
aagaatgatgtcatgatcagaaaagaggcttatgtacataaaagcgtgatggaggaactg
aagagaataattgacgacagtgaaattaccaaagaggatgatgcattgtggcctcctcct
gaccgagtgggccggcaggagcttgaaatcgtcattggagatgaacacatttcttttaca
acatcaaaaattggttcccttattgatgtcaatcaatccaaggatccagaaggcttacga
gtattttattatcttgtccaggacctgaagtgtttggtcttcagtcttattggattacac
ttcaagattaaaccaatctag

KEGG   Homo sapiens (human): 55110
Entry
55110             CDS       T01001                                 
Symbol
MAGOHB, MGN2, mago, magoh
Name
(RefSeq) mago homolog B, exon junction complex subunit
  KO
K12877  protein mago nashi
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
Network
nt06547  Spliceosome
  Element
N01972  Spliceosome catalysis (branching)
N01993  Spliceosome catalysis (exon ligation)
N01994  Spliceosome disassembly
N01995  mRNA export to the cytoplasm
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    55110 (MAGOHB)
  09122 Translation
   03013 Nucleocytoplasmic transport
    55110 (MAGOHB)
   03015 mRNA surveillance pathway
    55110 (MAGOHB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    55110 (MAGOHB)
   03041 Spliceosome [BR:hsa03041]
    55110 (MAGOHB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     55110 (MAGOHB)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    55110 (MAGOHB)
SSDB
Motif
Pfam: Mago_nashi
Other DBs
NCBI-GeneID: 55110
NCBI-ProteinID: NP_060518
OMIM: 619552
HGNC: 25504
Ensembl: ENSG00000111196
UniProt: Q96A72 A0A023T6R1
Structure
LinkDB
Position
12:complement(10599524..10613609)
AA seq 148 aa
MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVME
ELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEG
LRVFYYLVQDLKCLVFSLIGLHFKIKPI
NT seq 447 nt   +upstreamnt  +downstreamnt
atggctgtggctagcgatttctacctgcgctactacgtagggcacaagggcaagtttggg
cacgagtttctggagttcgaatttcggccggacggaaagcttagatatgccaacaacagc
aattacaaaaatgatgtcatgatcagaaaagaggcttatgtgcacaagagtgtaatggaa
gaactgaagagaattattgatgacagtgaaattacaaaagaagatgatgctttgtggcct
ccccctgatagggttggccgacaggagcttgaaattgtaattggagatgagcacatatct
tttaccacatcaaaaataggttctcttattgatgtaaatcagtcaaaggatcctgaaggc
cttcgagtattttactatttggtacaagacttgaaatgtttagttttcagtcttattgga
ttacacttcaagattaaaccaatttaa

KEGG   Homo sapiens (human): 9939
Entry
9939              CDS       T01001                                 
Symbol
RBM8A, BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1
Name
(RefSeq) RNA binding motif protein 8A
  KO
K12876  RNA-binding protein 8A
Organism
hsa  Homo sapiens (human)
Pathway
hsa03013  Nucleocytoplasmic transport
hsa03015  mRNA surveillance pathway
hsa03040  Spliceosome
Network
nt06547  Spliceosome
  Element
N01972  Spliceosome catalysis (branching)
N01993  Spliceosome catalysis (exon ligation)
N01994  Spliceosome disassembly
N01995  mRNA export to the cytoplasm
Disease
H01847  Thrombocytopenia-absent radius syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    9939 (RBM8A)
  09122 Translation
   03013 Nucleocytoplasmic transport
    9939 (RBM8A)
   03015 mRNA surveillance pathway
    9939 (RBM8A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    9939 (RBM8A)
   03041 Spliceosome [BR:hsa03041]
    9939 (RBM8A)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    EJC complex
     9939 (RBM8A)
Spliceosome [BR:hsa03041]
 Complex C
  Other components
   EJC/TREX
    9939 (RBM8A)
SSDB
Motif
Pfam: RRM_1 RRM_3 RRM_5
Other DBs
NCBI-GeneID: 9939
NCBI-ProteinID: NP_005096
OMIM: 605313
HGNC: 9905
Ensembl: ENSG00000265241
UniProt: Q9Y5S9 A0A023T787
Structure
LinkDB
Position
1:complement(145921556..145927484)
AA seq 174 aa
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQD
GDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVE
YETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
NT seq 525 nt   +upstreamnt  +downstreamnt
atggcggacgtgctagatcttcacgaggctgggggcgaagatttcgccatggatgaggat
ggggacgagagcattcacaaactgaaagaaaaagcgaagaaacggaagggtcgcggcttt
ggctccgaagaggggtcccgagcgcggatgcgtgaggattatgacagcgtggagcaggat
ggcgatgaacccggaccacaacgctctgttgaaggctggattctctttgtaactggagtc
catgaggaagccaccgaagaagacatacacgacaaattcgcagaatatggggaaattaaa
aacattcatctcaacctcgacaggcgaacaggatatctgaaggggtatactctagttgaa
tatgaaacatacaaggaagcccaggctgctatggagggactcaatggccaggatttgatg
ggacagcccatcagcgttgactggtgttttgttcggggtccaccaaaaggcaagaggaga
ggtggccgaagacgcagcagaagtccagaccggagacgtcgctga

DBGET integrated database retrieval system