KEGG   NETWORK: N01972
Entry
N01972                      Network                                
Name
Spliceosome catalysis (branching)
Definition
Bact == DHX38+YJU2+CWC25+ISY1 -- DHX16 -> B*complex == EJC -- CWC25+YJU2 -> Ccomplex
  Expanded
(6066+23451+10992+23450+10262+83443+51639+84844+10291+8175+10946+6627+6629+6628+7307+11338+6634+6632+6633+6635+6636+6637+26827+26831,26832+9343+23020+24148+10594+9410+10907+26827+84950+4236+153527+11193+9092+10465+55234+59286)+(27339+988+10286+5356+51503+3312+56259)+(22938+56949+51340+51645+10450+55696+8896+9716)+8449+57703+7737+10283+5356+22938+51340+(84811+51634+79753) == 9785+55702+54883+57461 -- 8449 -> (6066+6627+6629+6628+7307+11338+6634+6632+6633+6635+6636+6637+26827+26831,26832+9343+23020+24148+10594+9410+10907+26827+84950+4236+153527+11193+9092+10465+55234+59286)+(27339+988+10286+5356+51503+3312+56259)+(22938+56949+51340+51645+10450+55696+8896+9716)+57703+5356+22938+51340+(9785+55702+54883+57461) == (9775+22794+4116,55110+9939) -- 54883+55702 -> (6066+6627+6629+6628+7307+11338+6634+6632+6633+6635+6636+6637+26827+26831,26832+9343+23020+24148+10594+9410+10907)+(27339+988+10286+51503+3312+56259)+56949+51645+10450+55696+8896+9716)+57703+5356+22938+51340+(9785+55702+54883+57461)+(9775+22794+4116,55110+9939)
Class
nt06547 Spliceosome
Type
Reference
Pathway
hsa03040  Spliceosome
Gene
6066  RNU2-1; RNA, U2 small nuclear 1
23451  SF3B1; splicing factor 3b subunit 1
10992  SF3B2; splicing factor 3b subunit 2
23450  SF3B3; splicing factor 3b subunit 3
10262  SF3B4; splicing factor 3b subunit 4
83443  SF3B5; splicing factor 3b subunit 5
51639  SF3B6; splicing factor 3b subunit 6
84844  PHF5A; PHD finger protein 5A
10291  SF3A1; splicing factor 3a subunit 1
8175  SF3A2; splicing factor 3a subunit 2
10946  SF3A3; splicing factor 3a subunit 3
6627  SNRPA1; small nuclear ribonucleoprotein polypeptide A'
6629  SNRPB2; small nuclear ribonucleoprotein polypeptide B2
6628  SNRPB; small nuclear ribonucleoprotein polypeptides B and B1
7307  U2AF1; U2 small nuclear RNA auxiliary factor 1
11338  U2AF2; U2 small nuclear RNA auxiliary factor 2
6634  SNRPD3; small nuclear ribonucleoprotein D3 polypeptide
6632  SNRPD1; small nuclear ribonucleoprotein D1 polypeptide
6633  SNRPD2; small nuclear ribonucleoprotein D2 polypeptide
6635  SNRPE; small nuclear ribonucleoprotein polypeptide E
6636  SNRPF; small nuclear ribonucleoprotein polypeptide F
6637  SNRPG; small nuclear ribonucleoprotein polypeptide G
26827  RNU6-1; RNA, U6 small nuclear 1
26831  RNU5A-1; RNA, U5A small nuclear 1
26832  RNU5B-1; RNA, U5B small nuclear 1
9343  EFTUD2; elongation factor Tu GTP binding domain containing 2
23020  SNRNP200; small nuclear ribonucleoprotein U5 subunit 200
24148  PRPF6; pre-mRNA processing factor 6
10594  PRPF8; pre-mRNA processing factor 8
9410  SNRNP40; small nuclear ribonucleoprotein U5 subunit 40
10907  TXNL4A; thioredoxin like 4A
84950  PRPF38A; pre-mRNA processing factor 38A
4236  MFAP1; microfibril associated protein 1
153527  ZMAT2; zinc finger matrin-type 2
11193  WBP4; WW domain binding protein 4
9092  SART1; spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
10465  PPIH; peptidylprolyl isomerase H
55234  SMU1; SMU1 DNA replication regulator and spliceosomal factor
59286  UBL5; ubiquitin like 5
27339  PRPF19; pre-mRNA processing factor 19
988  CDC5L; cell division cycle 5 like
10286  BCAS2; BCAS2 pre-mRNA processing factor
5356  PLRG1; pleiotropic regulator 1
51503  CWC15; CWC15 spliceosome associated protein
3312  HSPA8; heat shock protein family A (Hsp70) member 8
56259  CTNNBL1; catenin beta like 1
22938  SNW1; SNW domain containing 1
56949  XAB2; XPA binding protein 2
51340  CRNKL1; crooked neck pre-mRNA splicing factor 1
51645  PPIL1; peptidylprolyl isomerase like 1
10450  PPIE; peptidylprolyl isomerase E
55696  RBM22; RNA binding motif protein 22
8896  BUD31; BUD31 spliceosome associated protein
9716  AQR; aquarius intron-binding spliceosomal factor
8449  DHX16; DEAH-box helicase 16
57703  CWC22; CWC22 spliceosome associated protein
7737  RNF113A; ring finger protein 113A
10283  CWC27; CWC27 spliceosome associated cyclophilin
84811  BUD13; BUD13 spliceosome associated protein
51634  RBMX2; RNA binding motif protein X-linked 2
79753  SNIP1; Smad nuclear interacting protein 1
9785  DHX38; DEAH-box helicase 38
55702  YJU2; YJU2 splicing factor homolog
54883  CWC25; CWC25 spliceosome associated protein
57461  ISY1; ISY1 spliceosome associated protein
9775  EIF4A3; eukaryotic translation initiation factor 4A3
22794  CASC3; CASC3 exon junction complex subunit
4116  MAGOH; mago homolog, exon junction complex subunit
55110  MAGOHB; mago homolog B, exon junction complex subunit
9939  RBM8A; RNA binding motif protein 8A
Reference
PMID:36526860
  Authors
Rogalska ME, Vivori C, Valcarcel J
  Title
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects.
  Journal
Nat Rev Genet 24:251-269 (2023)
DOI:10.1038/s41576-022-00556-8
Reference
PMID:29360106
  Authors
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
  Title
Structure of the human activated spliceosome in three conformational states.
  Journal
Cell Res 28:307-322 (2018)
DOI:10.1038/cr.2018.14
Reference
PMID:31794245
  Authors
Wilkinson ME, Charenton C, Nagai K
  Title
RNA Splicing by the Spliceosome.
  Journal
Annu Rev Biochem 89:359-388 (2020)
DOI:10.1146/annurev-biochem-091719-064225
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