KEGG   Homo sapiens (human): 2752
Entry
2752              CDS       T01001                                 
Symbol
GLUL, DEE116, GLNS, GS, PIG43, PIG59
Name
(RefSeq) glutamate-ammonia ligase
  KO
K01915  glutamine synthetase [EC:6.3.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00910  Nitrogen metabolism
hsa01100  Metabolic pathways
hsa01230  Biosynthesis of amino acids
hsa04217  Necroptosis
hsa04724  Glutamatergic synapse
hsa04727  GABAergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01892  GABA metabolism and transport in glia
Disease
H00606  Early infantile epileptic encephalopathy
H00923  Congenital systemic glutamine deficiency
H01400  Secondary hyperammonemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    2752 (GLUL)
  09102 Energy metabolism
   00910 Nitrogen metabolism
    2752 (GLUL)
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    2752 (GLUL)
   00220 Arginine biosynthesis
    2752 (GLUL)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    2752 (GLUL)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2752 (GLUL)
   04727 GABAergic synapse
    2752 (GLUL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2752 (GLUL)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)
    6.3.1.2  glutamine synthetase
     2752 (GLUL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   2752 (GLUL)
SSDB
Motif
Pfam: Gln-synt_C Gln-synt_N
Other DBs
NCBI-GeneID: 2752
NCBI-ProteinID: NP_001028216
OMIM: 138290
HGNC: 4341
Ensembl: ENSG00000135821
UniProt: P15104 A8YXX4
Structure
LinkDB
Position
1:complement(182378098..182391790)
AA seq 373 aa
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgaccacctcagcaagttcccacttaaataaaggcatcaagcaggtgtacatgtccctg
cctcagggtgagaaagtccaggccatgtatatctggatcgatggtactggagaaggactg
cgctgcaagacccggaccctggacagtgagcccaagtgtgtggaagagttgcctgagtgg
aatttcgatggctctagtactttacagtctgagggttccaacagtgacatgtatctcgtg
cctgctgccatgtttcgggaccccttccgtaaggaccctaacaagctggtgttatgtgaa
gttttcaagtacaatcgaaggcctgcagagaccaatttgaggcacacctgtaaacggata
atggacatggtgagcaaccagcacccctggtttggcatggagcaggagtataccctcatg
gggacagatgggcacccctttggttggccttccaacggcttcccagggccccagggtcca
tattactgtggtgtgggagcagacagagcctatggcagggacatcgtggaggcccattac
cgggcctgcttgtatgctggagtcaagattgcggggactaatgccgaggtcatgcctgcc
cagtgggaatttcagattggaccttgtgaaggaatcagcatgggagatcatctctgggtg
gcccgtttcatcttgcatcgtgtgtgtgaagactttggagtgatagcaacctttgatcct
aagcccattcctgggaactggaatggtgcaggctgccataccaacttcagcaccaaggcc
atgcgggaggagaatggtctgaagtacatcgaggaggccattgagaaactaagcaagcgg
caccagtaccacatccgtgcctatgatcccaagggaggcctggacaatgcccgacgtcta
actggattccatgaaacctccaacatcaacgacttttctgctggtgtagccaatcgtagc
gccagcatacgcattccccggactgttggccaggagaagaagggttactttgaagatcgt
cgcccctctgccaactgcgaccccttttcggtgacagaagccctcatccgcacgtgtctt
ctcaatgaaaccggcgatgagcccttccagtacaaaaattaa

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