Homo sapiens (human): 5073 Help Entry 5073              CDS       T01001                                  Symbol PARN, DAN, DKCB6, PFBMFT4 Name (RefSeq) poly(A)-specific ribonuclease   KO K01148   poly(A)-specific ribonuclease [EC:3.1.13.4] Organism hsa  Homo sapiens (human) Pathway hsa03018   RNA degradation Network nt06510  Telomere length regulation   Element N01475   Telomerase RNA maturation Disease H00507   Dyskeratosis congenita H02569   Pulmonary fibrosis and/or bone marrow failure, telomere-related Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09123 Folding, sorting and degradation    03018 RNA degradation     5073 (PARN)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03019 Messenger RNA biogenesis [BR:hsa03019]     5073 (PARN) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.13  Exoribonucleases producing 5'-phosphomonoesters     3.1.13.4  poly(A)-specific ribonuclease      5073 (PARN) Messenger RNA biogenesis [BR:hsa03019]  Eukaryotic type   mRNA degradation factors    3'-5' decay     Other 3'-5' decay factors      5073 (PARN) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  CAF1 RNA_bind R3H RRM_Thc1 NCBP3 RRM_1 T6PP_C Motif Other DBs NCBI-GeneID:  5073 NCBI-ProteinID:  NP_002573 OMIM:  604212 HGNC:  8609 Ensembl:  ENSG00000140694 UniProt:  O95453 B3KN69 Structure PDBPDBj LinkDB All DBs Position 16:complement(14435701..14630260) Genome browser AA seq 639 aa AA seqDB search MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKH SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKF IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF YCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFN KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS AFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLN PQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEP LSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW NT seq 1920 nt NT seq  +upstreamnt  +downstreamnt atggagataatcaggagcaattttaagagtaatcttcacaaagtgtaccaggccatagag gaggccgacttcttcgccatcgatggggagttttcaggaatcagtgatggaccttcagtc tctgcattaacaaatggttttgacactccagaagagaggtatcagaagcttaaaaagcat tccatggactttttgctatttcagtttggcctttgcacttttaagtatgactacacagat tcaaagtatataacgaagtcatttaacttctatgttttcccgaaacccttcaatagatcc tcaccagatgtcaaatttgtttgtcagagctccagcattgactttctagcaagccaggga tttgattttaataaagtttttcgaaatggaattccatatttaaatcaggaagaagaaaga cagttaagagagcagtatgatgaaaaacgttcacaggcgaatggtgcaggagctctgtcc tatgtatctcctaacacttcaaaatgtcctgtcacgattcctgaggatcaaaagaagttt attgaccaagtggtagagaaaatagaggatttattacaaagtgaagaaaacaagaacttg gatttagagccatgtaccgggttccaaagaaaactaatttatcagactttgagctggaag tatccgaaaggcattcatgttgagactttagaaactgaaaagaaggagcgatatatagtt atcagcaaagtagatgaagaagaacgcaaaagaagagagcagcagaaacatgccaaagaa caggaggagctgaatgatgctgtgggattttctagagtcattcacgccattgctaattcg ggaaaacttgttattggacacaatatgctcttggacgtcatgcacacagttcatcagttc tactgccctctgcctgcggacttaagtgagtttaaagagatgacaacatgtgttttcccc agactcttggatactaaattgatggccagcacacaaccttttaaggatatcattaacaac acatcccttgcggaattggaaaagcggttaaaagagacacctttcaaccctcctaaagtt gaaagtgccgaaggttttccaagttatgacacagcctctgaacaactccacgaggcaggc tacgatgcctacatcacagggctgtgcttcatctccatggccaattacctaggttctttt ctcagccctccaaaaattcatgtgtctgccagatcaaaactcattgaacctttttttaac aagttatttcttatgagggtcatggatatcccctatctaaacttggaaggaccagacttg cagcctaaacgtgatcatgttctccatgtgacattccccaaagaatggaaaaccagcgac ctttaccagcttttcagtgcctttggtaacattcagatatcctggattgatgacacatca gcatttgtttcccttagccagcccgagcaagtaaagattgctgtcaataccagcaaatat gcagaaagctatcggatccaaacctatgctgaatatatggggagaaaacaggaagagaag cagatcaaaagaaagtggactgaagatagctggaaggaggctgacagcaaacggttaaac ccccagtgcataccctacaccctgcagaatcactattaccgcaacaatagttttacagct cccagcacagtaggaaagagaaatttgagtcctagtcaagaggaagctggcctggaggac ggagtgtcaggggagatttccgacactgagcttgagcagaccgattcctgtgcagagccc ctctcagagggaaggaaaaaggccaagaaattaaaaagaatgaagaaggagctttctcca gcaggaagcatctcgaagaacagccctgccacactctttgaagttcctgacacatggtaa

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