KEGG   VARIANT: 2322v2
Entry
2322v2                      Variant                                
Name
FLT3 internal tandem duplication (ITD)
Type
Gain of function
Gene
FLT3  fms related receptor tyrosine kinase 3 [KO:K05092]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
FLT3-ITD
ClinVar: 16270
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06219  JAK-STAT signaling (cancer)
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00003  Acute myeloid leukemia
Drug target
Gilteritinib (DG01948): D10800<JP/US>
Midostaurin: D05029<US>
Pexidartinib (DG02960): D11270 D11271<US>
Quizartinib (DG01364): D09956<JP/US>
Reference
PMID:12951584
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
PMID:17124058
  Authors
Small D
  Title
FLT3 mutations: biology and treatment.
  Journal
Hematology Am Soc Hematol Educ Program 178-84 (2006)
DOI:10.1182/asheducation-2006.1.178
Reference
PMID:16236521
  Authors
Steffen B, Muller-Tidow C, Schwable J, Berdel WE, Serve H.
  Title
The molecular pathogenesis of acute myeloid leukemia.
  Journal
Crit Rev Oncol Hematol 56:195-221 (2005)
DOI:10.1016/j.critrevonc.2004.10.012
Reference
PMID:12194988
  Authors
Kelly LM, Gilliland DG.
  Title
Genetics of myeloid leukemias.
  Journal
Annu Rev Genomics Hum Genet 3:179-98 (2002)
DOI:10.1146/annurev.genom.3.032802.115046
LinkDB

DBGET integrated database retrieval system