KEGG ORTHOLOGY: K05092

ORTHOLOGY: K05092

Entry

K05092                      KO

Symbol

FLT3, FLK2, CD135

Name

fms-related tyrosine kinase 3 [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04151

PI3K-Akt signaling pathway

map04640

Hematopoietic cell lineage

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05221

Acute myeloid leukemia

map05230

Central carbon metabolism in cancer

Disease

H00003

Acute myeloid leukemia

H02411

Chronic myelomonocytic leukemia

H02412

Atypical chronic myeloid leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04014 Ras signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04151 PI3K-Akt signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05202 Transcriptional misregulation in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05230 Central carbon metabolism in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
CD molecules [BR:ko04090]
Proteins
  K05092  CD135, FLT3; fms-related tyrosine kinase 3

Genes

HSA:	2322(FLT3)

PTR:	452508(FLT3)

PPS:	100989601(FLT3)

GGO:	101131781(FLT3)

PON:	100454731(FLT3)

PPYG:

129011489(FLT3)

NLE:	100589184(FLT3)

HMH:	116467123(FLT3)

SSYN:

129463671(FLT3)

MCC:	114669851 721712(FLT3)

MCF:	102144988(FLT3)

MTHB:

126940719

MNI:	105490198(FLT3)

CSAB:

103249072(FLT3)

CATY:

105597061(FLT3)

PANU:

101004066(FLT3)

TGE:	112610848(FLT3)

MLEU:

105553811(FLT3)

RRO:	104661678(FLT3)

RBB:	108512945(FLT3)

TFN:	117097942(FLT3)

PTEH:

111540451(FLT3)

CANG:

105523475(FLT3)

CJC:	100413316(FLT3)

SBQ:	101027591(FLT3)

CIMI:

108310422(FLT3)

ANAN:

105730040(FLT3)

CSYR:

103264988(FLT3)

MMUR:

105858898(FLT3)

LCAT:

123648920(FLT3)

PCOQ:

105814785(FLT3)

OGA:	100947062(FLT3)

MMU:	14255(Flt3)

MCAL:

110294537(Flt3)

MPAH:

110312926(Flt3)

RNO:	140635(Flt3)

MCOC:

116068778(Flt3)

ANU:	117697747(Flt3)

ASYL:

127672586(Flt3)

CGE:	100761902(Flt3)

MAUA:

101824111(Flt3)

PROB:

127237147(Flt3)

PLEU:

114699133(Flt3)

MORG:

121464998(Flt3)

MFOT:

126513533

AAMP:

119824393(Flt3)

NGI:	103727235(Flt3)

HGL:	101713724(Flt3)

CPOC:

100732047(Flt3)

CCAN:

109694695(Flt3)

DORD:

105993900(Flt3)

DSP:	122112631(Flt3)

DMER:

138813550(Flt3)

PLOP:

125348391(Flt3)

NCAR:

124984996

MMMA:

107140769(Flt3)

ITI:	101960429(Flt3)

OCU:

108175474

OPI:	101534350(FLT3)

TUP:	106733545(FLT3)

GVR:	103603769(FLT3) 103610970

CFA:	486025(FLT3)

CLUD:

112669483(FLT3)

VVP:	112918638(FLT3)

VLG:	121498207(FLT3)

NPO:	129504598(FLT3)

AML:	100483963(FLT3)

UMR:	103664318(FLT3)

UAH:	113251210(FLT3)

UAR:	123791950(FLT3)

ELK:

111158528

LLV:

125096240

MPUF:

101685779(FLT3)

MNP:	132002715(FLT3)

MLK:	131813814(FLT3)

NVS:	122906985(FLT3)

ORO:	101382975(FLT3)

EJU:	114212788(FLT3)

ZCA:	113919946(FLT3)

MLX:	118009555(FLT3)

NSU:	110570275(FLT3)

LWW:	102737729(FLT3)

FCA:	101099264(FLT3)

PYU:	121012779(FLT3)

PBG:	122480968(FLT3)

PVIV:

125175495(FLT3)

LRUF:

124511181

LGF:	123591278(FLT3)

AJU:

106985565

PTG:	102955843(FLT3)

PPAD:

109266125(FLT3)

PUC:

125934067

PLEZ:

122220415(FLT3)

HHV:	120247007(FLT3)

BTA:	512700(FLT3)

BOM:	102272113(FLT3)

BIU:	109567013(FLT3)

BBUB:

102402092(FLT3)

BBIS:

104996835(FLT3)

CHX:	102189319(FLT3)

OAS:	101112331(FLT3)

BTAX:

128057569(FLT3)

CSUM:

138089022(FLT3)

ODA:	120882918(FLT3)

CCAD:

122447566(FLT3)

MREE:

136144289(FLT3)

OVR:	110130325(FLT3)

MBEZ:

129556612(FLT3)

SSC:	100515445(FLT3)

CFR:	102508422(FLT3)

CBAI:

105066246(FLT3)

CDK:	105086582(FLT3)

VPC:	102530902(FLT3)

BACU:

103008462(FLT3)

BMUS:

118884201(FLT3)

LVE:	103080479(FLT3)

OOR:	101278112(FLT3)

LALB:

132508987(FLT3)

GMF:	115866761(FLT3)

DLE:	111175185(FLT3)

PCAD:

102989448(FLT3)

PSIU:

116743304(FLT3)

PPHC:

136137875(FLT3)

NASI:

112406702(FLT3)

ECB:	100061780(FLT3)

EPZ:	103562043(FLT3)

EAI:	106832906(FLT3)

MYB:	102244263(FLT3)

MYD:	102760103(FLT3)

MMYO:

118651974(FLT3)

MLF:	102420687(FLT3)

MDT:	132228127(FLT3)

MYUM:

139006772(FLT3)

PKL:	118730455(FLT3)

EFUS:

103296752(FLT3)

MNA:	107534352(FLT3)

DRO:	112323198(FLT3)

SHON:

118995806(FLT3)

AJM:	119064963(FLT3)

PDIC:

114489000(FLT3)

PHAS:

123822727(FLT3)

MMF:	118624675(FLT3)

PPAM:

129073410(FLT3)

HAI:	109395206(FLT3)

RFQ:	117021070(FLT3)

PALE:

102891572(FLT3)

PGIG:

120602461(FLT3)

PVP:	105292132(FLT3)

RAY:	107514324(FLT3)

MJV:	108407453(FLT3)

TOD:	119258796(FLT3)

SARA:

101545300(FLT3)

SFUM:

130019412(FLT3)

SETR:

126015636(FLT3)

LAV:	100668366(FLT3)

TMU:

101352048

ETF:	101654556(FLT3)

DNM:	101424442(FLT3)

MDO:	100025262(FLT3)

GAS:	123241275(FLT3)

SHR:	100929912(FLT3)

AFZ:

127554719

PCW:	110215617(FLT3)

TVP:	118836882(FLT3)

PBRV:

138154692(FLT3)

MLAO:

141507951(FLT3)

OAA:	100090467(FLT3)

TACU:

119941457(FLT3)

GGA:	100858422(FLT3)

PCOC:

116244111(FLT3)

MGP:	100542111(FLT3)

CJO:	107308287(FLT3)

TPAI:

128074997(FLT3)

LMUT:

125688094(FLT3)

NMEL:

110388941(FLT3)

APLA:

101794861(FLT3)

ACYG:

106041163(FLT3)

CATA:

118246030(FLT3)

AFUL:

116501572(FLT3)

TGU:	100230451(FLT3)

LSR:	110476711(FLT3)

SCAN:

103812551(FLT3)

PMOA:

120506645(FLT3)

OTC:	121341980(FLT3)

PRUF:

121364124(FLT3)

ATRC:

139593137(FLT3)

GFR:	102039519(FLT3)

FAB:	101807614(FLT3)

OMA:	130256213(FLT3)

PHI:	102112465(FLT3)

PMAJ:

107213698(FLT3)

CCAE:

111923247(FLT3)

CCW:	104689892(FLT3)

CBRC:

103613663(FLT3)

ACOE:

138119016(FLT3)

ETL:	114067515(FLT3)

ZAB:	102075109(FLT3)

ZLE:	135460515(FLT3)

ACHL:

103806192(FLT3)

SVG:	106855202(FLT3)

MMEA:

130573878(FLT3)

HRT:	120748636(FLT3)

SATI:

136357657(FLT3)

CCIC:

134057873(FLT3)

FPG:	101924556(FLT3)

FCH:	102052010(FLT3)

CCRI:

104166913(FLT3)

NNT:	104408125(FLT3)

SHAB:

115603844(FLT3)

ACUN:

113486345(FLT3)

TALA:

104355620(FLT3)

ACHC:

115353609(FLT3)

HALD:

104325541(FLT3)

HLE:	104835027(FLT3)

AGEN:

126048209

HHAR:

128153593(FLT3)

GCL:

127024685

CSTI:

104560678(FLT3)

LDI:	104340192(FLT3)

MNB:	103773590(FLT3)

DPUB:

104306117(FLT3)

PPUS:

135173312(FLT3)

AVIT:

104267561(FLT3)

BRHI:

104492386(FLT3)

EGZ:	104133700(FLT3)

NNI:	104023083(FLT3)

PCRI:

104032069(FLT3)

PCAO:

104042809(FLT3)

PADL:

103920186(FLT3)

AFOR:

103908003(FLT3)

FGA:	104069735(FLT3)

GSTE:

104250671(FLT3)

CBOY:

140649748(FLT3)

CLV:	102092160(FLT3)

CNIC:

135996788(FLT3)

MUI:	104539452(FLT3)

PGUU:

104458624(FLT3)

PLET:

104622141(FLT3)

EHS:	104503110(FLT3)

CMAC:

104473346(FLT3)

CUCA:

104064233(FLT3)

TEO:	104382475(FLT3)

BREG:

104636324(FLT3)

OHA:	104332732(FLT3)

ACAR:

104517950(FLT3)

CPEA:

104395903(FLT3)

CVF:	104284503(FLT3)

RTD:	128914396(FLT3)

CRID:

134517970(FLT3)

AAM:	106500428(FLT3)

AROW:

112970195(FLT3)

NPD:	112956313(FLT3)

TGT:	104565128(FLT3)

DNE:	112988349(FLT3)

SCAM:

104151588(FLT3)

ASN:	102372238(FLT3)

AMJ:	102566323(FLT3)

CPOO:

109306630(FLT3)

GGN:	109303396(FLT3)

PSS:	102460565(FLT3)

CMY:	102932199(FLT3)

CCAY:

125635127(FLT3)

DCC:	119850618(FLT3)

CPIC:

101945244(FLT3)

TST:	117871082(FLT3)

CABI:

116816244(FLT3)

MRV:	120395772(FLT3)

ACS:	100557093(flt3)

ASAO:

132772119(FLT3)

PVT:	110076475(FLT3)

SUND:

121926291(FLT3)

PBI:	103049084(FLT3)

PMUR:

107287178(FLT3)

CTIG:

120314094(FLT3)

PGUT:

117664257(FLT3)

PCAE:

139316990(FLT3)

APRI:

131200154(FLT3)

PTEX:

113441673(FLT3)

NSS:	113416920(FLT3)

VKO:	123029521(FLT3)

PMUA:

114595759(FLT3)

PRAF:

128412700(FLT3)

ZVI:	118085540(FLT3)

HCG:	128350826(FLT3)

GJA:	107105445(FLT3)

STOW:

125431277(FLT3)

EMC:	129326288(FLT3)

XLA:	108707566 108709958

XTR:	101733150(flt3)

NPR:	108796338(FLT3)

RTEM:

120929196(FLT3)

ACAT:

141127158(FLT3)

BBUF:

120996320(FLT3)

BGAR:

122930925(FLT3)

DTC:	141096490(FLT3)

PWL:	138248544(FLT3)

MUO:	115468548(FLT3)

GSH:	117362364(FLT3)

DRE:	566708(flt3)

SRX:	107705193 107716378

SANH:

107654204 107701629

SGH:	107584975 107591276

CCAR:

109069462(flt3) 109099626

CAUA:

113041933 113066258

CGIB:

127946389 128013402

PTET:

122330056(flt3)

LROH:

127155859(flt3)

GRF:	141300649(flt3)

OMC:	131532893(flt3)

PPRM:

120476078(flt3)

RKG:	130083881(flt3)

MAMB:

125258183(flt3)

CIDE:

127506104

CERY:

137013650(flt3)

MASI:

127432045 127434569

TROS:

130547245(flt3)

TDW:	130413133(flt3)

MANU:

129426191(flt3)

PDAB:

135740137(flt3)

IPU:

108256707

IFU:	128599382(flt3)

PHYP:

113541064(flt3)

SMEO:

124403659(flt3)

TFD:	113661300(flt3)

TVC:	132839919(flt3)

CGAR:

128514493(flt3)

NGRA:

132867093(flt3)

TRN:	134300806(flt3)

AMEX:

103023809(flt3)

CMAO:

118798656 118798658

EEE:	113576161(flt3)

CHAR:

122131722(flt3)

SPIL:

134066253(flt3)

TRU:	101070905(flt3)

TFS:	130513727(flt3)

LCO:	104924953(flt3)

TBEN:

117494858(flt3)

CGOB:

115025366(flt3)

PGEO:

117465614(flt3)

GACU:

117554983(flt3)

EMAC:

134883894(flt3)

ELY:	117264654(flt3)

EFO:	125881839(flt3)

PLEP:

121960726(flt3)

SLUC:

116037937(flt3)

ECRA:

117938211(flt3)

ESP:	116672539(flt3)

PFLV:

114549361(flt3)

GAT:	120811853(flt3)

PPUG:

119198804 119198965

AFB:	129110614(flt3)

CLUM:

117749691(flt3)

PSWI:

130206173(flt3)

CANA:

137788776(flt3)

CVE:	137888835(flt3)

MSAM:

119887189 119909737(flt3)

SCHU:

122866262(flt3)

CUD:	121527587(flt3)

SPUL:

138595799(flt3)

LMIX:

132994015(flt3)

ALAT:

119008429(flt3)

ASTR:

137587506(flt3)

MZE:	101480071 101480562(flt3)

ONL:	100700726 102078401

OAU:	116312155 116314403 120441727

OLA:	101173420(flt3) 110013400

OML:	112151478(flt3) 112151601

CSAI:

133423061(flt3)

XMA:	102218761(flt3) 111606303

XCO:	114136905(flt3) 114136908

XHE:	116711620 116711622

PRET:

103456624(flt3)

PFOR:

103139804(flt3)

PMEI:

106903397

GAF:	122824131(flt3) 122824133

PPRL:

129364995

CVG:

107090784

CTUL:

119789072(flt3)

GMU:	124857939(flt3)

NFU:	107382872(flt3)

KMR:	108230288(flt3)

ALIM:

106513431(flt3)

NWH:	119426402(flt3)

AOCE:

111584742(flt3)

EJA:	138199549(flt3)

BFRE:

138623870(flt3)

MCEP:

124995437 124995438 124995439

CSEM:

103377257(flt3)

POV:	109642362(flt3)

SSEN:

122773942(flt3)

SSOE:

131465466(flt3)

HHIP:

117753770(flt3)

HSP:	118098887(flt3)

PPLT:

128425882(flt3)

SMAU:

118291476(flt3)

LCF:

108881765

SDU:	111220948(flt3)

SLAL:

111662946(flt3)

XGL:	120789679(flt3)

HCQ:	109514067(flt3)

SSCV:

125986190(flt3)

SBIA:

133492629(flt3)

PEE:	133396489(flt3)

PTAO:

133470079(flt3)

BPEC:

110160944(flt3)

ENY:	140364591(flt3)

MALB:

109960111

BSPL:

114854804(flt3)

SJO:	128382874(flt3)

SSCO:

134002231(flt3)

GMH:	115537634(flt3)

SASA:

106579503 106590453

STRU:

115151084(flt3)

OTW:	112227703(flt3)

OMY:	110490925(flt3)

OGO:	123991313(flt3) 124039557

ONE:	115104944 115130124

OKI:	109899248 109909873

OKE:	118372534(flt3) 118378053

OMM:	135517237(flt3)

OCLA:

139366978

SALP:

111953846 111973523

SNH:	120028108(flt3) 120050607

CCLU:

121549840(flt3) 121569252

ELS:	105021947(flt3)

OEP:	134034926(flt3)

SFM:	108939670(flt3)

PKI:	111839117(flt3)

AANG:

118225408(flt3)

AROT:

135253049(flt3)

CCOG:

133127672(flt3)

LOC:	102685435(flt3)

PSPA:

121302745(flt3)

ARUT:

117407344

PSEX:

120523843(flt3)

LCM:	102346199(FLT3)

CMK:	103183285(flt3)

RTP:	109913625(flt3)

CPLA:

122550769(flt3)

HOC:	132816949(flt3)

LERI:

129698058(flt3)

HAKA:

140726871(flt3)

CNS:

HRJ:

EPA:

Reference

PMID:7507245

Authors

Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, et al.

Title

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

Journal

Proc Natl Acad Sci U S A 91:459-63 (1994)
DOI:10.1073/pnas.91.2.459

Sequence

[hsa:2322]

Reference

PMID:19549778

Authors

Meshinchi S, Appelbaum FR

Title

Structural and functional alterations of FLT3 in acute myeloid leukemia.

Journal

Clin Cancer Res 15:4263-9 (2009)
DOI:10.1158/1078-0432.CCR-08-1123

LinkDB

DBGET integrated database retrieval system