ORTHOLOGY: K05092 Help
Entry
Symbol
FLT3, FLK2, CD135
Name
fms-related tyrosine kinase 3 [EC:
2.7.10.1 ]
Pathway
map05202 Transcriptional misregulation in cancer
map05230 Central carbon metabolism in cancer
Disease
H02411 Chronic myelomonocytic leukemia
H02412 Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
04014 Ras signaling pathway
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
04151 PI3K-Akt signaling pathway
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
05202 Transcriptional misregulation in cancer
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
05230 Central carbon metabolism in cancer
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09162 Cancer: specific types
05221 Acute myeloid leukemia
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
09183 Protein families: signaling and cellular processes
04090 CD molecules
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Enzymes [BR:ko01000 ]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Protein kinases [BR:ko01001 ]
Receptor tyrosine kinases (RTK)
PDGFR family [OT]
K05092 FLT3, FLK2, CD135; fms-related tyrosine kinase 3
CD molecules [BR:ko04090 ]
Proteins
K05092 CD135, FLT3; fms-related tyrosine kinase 3
BRITE hierarchy
Genes
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Taxonomy UniProt
Reference
Authors
Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, et al.
Title
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
Journal
Sequence
Reference
Authors
Meshinchi S, Appelbaum FR
Title
Structural and functional alterations of FLT3 in acute myeloid leukemia.
Journal
LinkDB
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