KEGG   ORTHOLOGY: K05092
Entry
K05092                      KO                                     
Symbol
FLT3, FLK2, CD135
Name
fms-related tyrosine kinase 3 [EC:2.7.10.1]
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04151  PI3K-Akt signaling pathway
map04640  Hematopoietic cell lineage
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05221  Acute myeloid leukemia
map05230  Central carbon metabolism in cancer
Disease
H00003  Acute myeloid leukemia
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04014 Ras signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   04151 PI3K-Akt signaling pathway
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05202 Transcriptional misregulation in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
   05230 Central carbon metabolism in cancer
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   K05092  FLT3, FLK2, CD135; fms-related tyrosine kinase 3
CD molecules [BR:ko04090]
 Proteins
  K05092  CD135, FLT3; fms-related tyrosine kinase 3
Genes
HSA: 2322(FLT3)
PTR: 452508(FLT3)
PPS: 100989601(FLT3)
GGO: 101131781(FLT3)
PON: 100454731(FLT3)
NLE: 100589184(FLT3)
MCC: 114669851 721712(FLT3)
MCF: 102144988(FLT3)
CSAB: 103249072(FLT3)
CATY: 105597061(FLT3)
PANU: 101004066(FLT3)
TGE: 112610848(FLT3)
RRO: 104661678(FLT3)
RBB: 108512945(FLT3)
TFN: 117097942(FLT3)
PTEH: 111540451(FLT3)
CJC: 100413316(FLT3)
SBQ: 101027591(FLT3)
CSYR: 103264988(FLT3)
MMUR: 105858898(FLT3)
OGA: 100947062(FLT3)
MMU: 14255(Flt3)
MCAL: 110294537(Flt3)
MPAH: 110312926(Flt3)
RNO: 140635(Flt3)
MCOC: 116068778(Flt3)
CGE: 100761902(Flt3)
PLEU: 114699133(Flt3)
NGI: 103727235(Flt3)
HGL: 101713724(Flt3)
CPOC: 100732047(Flt3)
CCAN: 109694695(Flt3)
DORD: 105993900(Flt3)
DSP: 122112631(Flt3)
NCAR: 124984996
OCU: 108175474(FLT3)
OPI: 101534350(FLT3)
TUP: 106733545(FLT3)
CFA: 486025(FLT3)
VVP: 112918638(FLT3)
VLG: 121498207(FLT3)
AML: 100483963(FLT3)
UMR: 103664318(FLT3)
UAH: 113251210(FLT3)
UAR: 123791950(FLT3)
ELK: 111158528
LLV: 125096240
MPUF: 101685779(FLT3)
ORO: 101382975(FLT3)
EJU: 114212788(FLT3)
ZCA: 113919946(FLT3)
MLX: 118009555(FLT3)
FCA: 101099264(FLT3)
PYU: 121012779(FLT3)
PBG: 122480968(FLT3)
PTG: 102955843(FLT3)
PPAD: 109266125(FLT3)
AJU: 106985565(FLT3)
HHV: 120247007(FLT3)
BTA: 512700(FLT3)
BOM: 102272113(FLT3)
BIU: 109567013(FLT3)
BBUB: 102402092(FLT3)
CHX: 102189319(FLT3)
OAS: 101112331(FLT3)
ODA: 120882918(FLT3)
CCAD: 122447566(FLT3)
SSC: 100515445(FLT3)
CFR: 102508422(FLT3)
CBAI: 105066246(FLT3)
CDK: 105086582(FLT3)
VPC: 102530902(FLT3)
BACU: 103008462(FLT3)
LVE: 103080479(FLT3)
OOR: 101278112(FLT3)
DLE: 111175185(FLT3)
PCAD: 102989448(FLT3)
PSIU: 116743304(FLT3)
ECB: 100061780(FLT3)
EPZ: 103562043(FLT3)
EAI: 106832906(FLT3)
MYB: 102244263(FLT3)
MYD: 102760103(FLT3)
MMYO: 118651974(FLT3)
MLF: 102420687(FLT3)
MNA: 107534352(FLT3)
PKL: 118730455(FLT3)
HAI: 109395206(FLT3)
DRO: 112323198(FLT3)
SHON: 118995806(FLT3)
AJM: 119064963(FLT3)
PDIC: 114489000(FLT3)
PHAS: 123822727(FLT3)
MMF: 118624675(FLT3)
RFQ: 117021070(FLT3)
PALE: 102891572(FLT3)
PGIG: 120602461(FLT3)
PVP: 105292132(FLT3)
RAY: 107514324(FLT3)
MJV: 108407453(FLT3)
TOD: 119258796(FLT3)
SARA: 101545300(FLT3)
LAV: 100668366(FLT3)
TMU: 101352048
DNM: 101424442(FLT3)
MDO: 100025262(FLT3)
GAS: 123241275(FLT3)
SHR: 100929912(FLT3)
PCW: 110215617(FLT3)
OAA: 100090467(FLT3)
GGA: 100858422(FLT3)
PCOC: 116244111(FLT3)
MGP: 100542111(FLT3)
CJO: 107308287(FLT3)
NMEL: 110388941(FLT3)
APLA: 101794861(FLT3)
ACYG: 106041163(FLT3)
AFUL: 116501572(FLT3)
TGU: 100230451(FLT3)
LSR: 110476711(FLT3)
SCAN: 103812551(FLT3)
PMOA: 120506645(FLT3)
OTC: 121341980(FLT3)
PRUF: 121364124(FLT3)
GFR: 102039519(FLT3)
FAB: 101807614(FLT3)
PHI: 102112465(FLT3)
PMAJ: 107213698(FLT3)
CCAE: 111923247(FLT3)
CCW: 104689892(FLT3)
ETL: 114067515(FLT3)
ZAB: 102075109(FLT3)
FPG: 101924556(FLT3)
FCH: 102052010(FLT3)
CLV: 102092160(FLT3)
EGZ: 104133700(FLT3)
NNI: 104023083(FLT3)
ACUN: 113486345(FLT3)
TALA: 104355620(FLT3)
PADL: 103920186(FLT3)
ACHC: 115353609(FLT3)
AAM: 106500428(FLT3)
AROW: 112970195(FLT3)
NPD: 112956313(FLT3)
DNE: 112988349(FLT3)
ASN: 102372238(FLT3)
AMJ: 102566323(FLT3)
CPOO: 109306630(FLT3)
GGN: 109303396(FLT3)
PSS: 102460565(FLT3)
CMY: 102932199(FLT3)
CPIC: 101945244(FLT3)
TST: 117871082(FLT3)
CABI: 116816244(FLT3)
MRV: 120395772(FLT3)
ACS: 100557093(flt3)
PVT: 110076475(FLT3)
SUND: 121926291(FLT3)
PBI: 103049084(FLT3)
PMUR: 107287178(FLT3)
PGUT: 117664257(FLT3)
VKO: 123029521(FLT3)
PMUA: 114595759(FLT3)
ZVI: 118085540(FLT3)
GJA: 107105445(FLT3)
XTR: 101733150(flt3)
NPR: 108796338(FLT3)
RTEM: 120929196(FLT3)
BBUF: 120996320(FLT3)
BGAR: 122930925(FLT3)
DRE: 566708(flt3)
IPU: 108256707(flt3)
PHYP: 113541064(flt3)
SMEO: 124403659(flt3)
TFD: 113661300(flt3)
AMEX: 103023809(flt3)
EEE: 113576161(flt3)
TRU: 101070905(flt3)
LCO: 104924953(flt3)
CGOB: 115025366(flt3)
ELY: 117264654(flt3)
PLEP: 121960726(flt3)
SLUC: 116037937(flt3)
ECRA: 117938211(flt3)
PFLV: 114549361(flt3)
GAT: 120811853(flt3)
MSAM: 119887189 119909737(flt3)
CUD: 121527587(flt3)
MZE: 101480071 101480562(flt3)
OLA: 101173420(flt3) 110013400
OML: 112151478(flt3) 112151601
XMA: 102218761(flt3) 111606303
XCO: 114136905(flt3) 114136908
PRET: 103456624(flt3)
PFOR: 103139804(flt3)
PMEI: 106903397
GAF: 122824131(flt3) 122824133
CVG: 107090784
CTUL: 119789072(flt3)
GMU: 124857939(flt3)
NFU: 107382872(flt3)
KMR: 108230288(flt3)
ALIM: 106513431(flt3)
NWH: 119426402(flt3)
AOCE: 111584742(flt3)
CSEM: 103377257(flt3)
POV: 109642362(flt3)
SSEN: 122773942(flt3)
HHIP: 117753770(flt3)
LCF: 108881765(flt3)
SDU: 111220948(flt3)
SLAL: 111662946(flt3)
XGL: 120789679(flt3)
HCQ: 109514067(flt3)
BPEC: 110160944(flt3)
MALB: 109960111
OTW: 112227703(flt3)
OMY: 110490925(flt3)
OGO: 123991313(flt3) 124039557
SNH: 120028108(flt3) 120050607
ELS: 105021947(flt3)
SFM: 108939670(flt3)
PKI: 111839117(flt3)
AANG: 118225408(flt3)
LOC: 102685435(flt3)
PSPA: 121302745(flt3)
ARUT: 117407344
LCM: 102346199(FLT3)
CMK: 103183285(flt3)
RTP: 109913625(flt3)
CNS: 116345729
HRJ: 124286110
EPA: 110241050
ATEN: 116286865
 » show all
Reference
PMID:7507245
  Authors
Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P, Witte L, Burrow C, Ratajczak MZ, Gewirtz AM, et al.
  Title
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
  Journal
Proc Natl Acad Sci U S A 91:459-63 (1994)
DOI:10.1073/pnas.91.2.459
  Sequence
[hsa:2322]
Reference
  Authors
Meshinchi S, Appelbaum FR
  Title
Structural and functional alterations of FLT3 in acute myeloid leukemia.
  Journal
Clin Cancer Res 15:4263-9 (2009)
DOI:10.1158/1078-0432.CCR-08-1123
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