| Entry |
|
|---|
| Name |
Pexidartinib (USAN/INN) |
|---|
| Formula |
C20H15ClF3N5
|
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| Exact mass |
417.0968
|
|---|
| Mol weight |
417.81
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
| Product (DG02960): | D11271<US> |
|
|---|
| Efficacy |
Antineoplastic, Macrophage colony-stimulating factor receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], UGT1A4 [HSA: 54657]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EX Other protein kinase inhibitors
L01EX15 Pexidartinib
D11270 Pexidartinib (USAN/INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02960 Pexidartinib
D11270 Pexidartinib
DG02924 UGT substrate
DG03182 UGT1A4 substrate
DG02960 Pexidartinib
D11270 Pexidartinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
KIT (CD117)
D11270 Pexidartinib (USAN/INN)
FLT3* (CD135) [HSA_VAR:2322v2]
D11270 Pexidartinib (USAN/INN)
Cytokines and receptors
Cytokine receptors
CSF and other factor receptors
CSF1R (FMS, CD115)
D11270 Pexidartinib (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11270
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02960 Pexidartinib
DG02924 UGT substrate
DG03182 UGT1A4 substrate
DG02960 Pexidartinib
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 C8x C 22.1900 -15.7500
2 C8y C 22.1900 -17.1500
3 C8x C 23.4024 -17.8500
4 N5x N 24.6149 -17.1500
5 C8y C 24.6149 -15.7500
6 C8x C 23.4024 -15.0500
7 C1d C 25.8460 -15.0390
8 X F 27.0584 -14.3390
9 X F 25.1460 -13.8265
10 X F 26.5460 -16.2514
11 C1b C 20.9776 -17.8500
12 N1b N 19.7821 -17.1596
13 C8y C 18.5947 -17.8451
14 N5x N 17.4035 -17.1571
15 C8x C 16.1910 -17.8569
16 C8y C 16.1908 -19.2569
17 C8x C 17.3820 -19.9449
18 C8x C 18.5945 -19.2451
19 C1b C 14.9658 -19.9641
20 C8y C 13.7581 -19.2667
21 C8x C 13.7945 -17.8500
22 N4x N 12.4631 -17.3771
23 C8y C 11.6019 -18.4972
24 C8y C 12.4010 -19.6624
25 N5x N 10.2061 -18.6057
26 C8x C 9.6022 -19.8688
27 C8y C 10.4013 -21.0339
28 C8x C 11.7971 -20.9254
29 X Cl 9.8163 -22.2583
BOND 32
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 7 10 1
11 2 11 1
12 11 12 1
13 12 13 1
14 13 14 2
15 14 15 1
16 15 16 2
17 16 17 1
18 17 18 2
19 13 18 1
20 16 19 1
21 19 20 1
22 20 21 2
23 21 22 1
24 22 23 1
25 23 24 1
26 20 24 1
27 23 25 2
28 25 26 1
29 26 27 2
30 27 28 1
31 24 28 2
32 27 29 1
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