KEGG   VARIANT: 3265v1
Entry
3265v1                      Variant                                
Name
HRAS overexpression
Type
Gain of function
Gene
HRAS  HRas proto-oncogene, GTPase [KO:K02833]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
overexpression
Network
nt06210  ERK signaling (cancer)
nt06265  Bladder cancer
nt06526  MAPK signaling
Disease
H00022  Bladder cancer
Reference
PMID:14532839
  Authors
Oxford G, Theodorescu D
  Title
The role of Ras superfamily proteins in bladder cancer progression.
  Journal
J Urol 170:1987-93 (2003)
DOI:10.1097/01.ju.0000088670.02905.78
LinkDB

KEGG   VARIANT: 3265v2
Entry
3265v2                      Variant                                
Name
HRAS mutation
Type
Gain of function
Gene
HRAS  HRas proto-oncogene, GTPase [KO:K02833]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G12S
ClinVar: 12602
dbSNP: rs104894229
COSM: 480
Variation
mutation G12C
ClinVar: 12613
dbSNP: rs104894229
COSM: 481
Variation
mutation G13R
ClinVar: 35554
dbSNP: rs104894228
COSM: 486
Variation
mutation G13V
ClinVar: 180848
dbSNP: rs104894226
COSM: 489
Variation
mutation Q61R
ClinVar: 160364
dbSNP: rs121913233
COSM: 499
Variation
mutation Q61L
ClinVar: 376033
dbSNP: rs121913233
COSM: 498
Network
nt06210  ERK signaling (cancer)
nt06265  Bladder cancer
nt06526  MAPK signaling
Disease
H00022  Bladder cancer
Reference
PMID:15897885
  Authors
Jebar AH, Hurst CD, Tomlinson DC, Johnston C, Taylor CF, Knowles MA
  Title
FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.
  Journal
Oncogene 24:5218-25 (2005)
DOI:10.1038/sj.onc.1208705
LinkDB

KEGG   VARIANT: 3845v1
Entry
3845v1                      Variant                                
Name
KRAS mutation
Type
Gain of function
Gene
KRAS  KRAS proto-oncogene, GTPase [KO:K07827]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G12D
ClinVar: 12582
dbSNP: rs121913529
COSM: 521
Variation
mutation G12V
ClinVar: 12583
dbSNP: rs121913529
COSM: 520
Variation
mutation G13D
ClinVar: 12580
dbSNP: rs112445441
COSM: 532
Variation
mutation G12C
ClinVar: 12578
dbSNP: rs121913530
COSM: 516
Network
nt06210  ERK signaling (cancer)
nt06213  Other RAS signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00003  Acute myeloid leukemia
H00014  Non-small cell lung cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00026  Endometrial cancer
H00032  Thyroid cancer
H00038  Melanoma
Drug target
Adagrasib: D12301<US>
Opnurasib: D13038
Sotorasib: D12055<JP/US>
Reference
PMID:22589270
  Authors
Prior IA, Lewis PD, Mattos C
  Title
A comprehensive survey of Ras mutations in cancer.
  Journal
Cancer Res 72:2457-67 (2012)
DOI:10.1158/0008-5472.CAN-11-2612
Reference
PMID:15951308
  Authors
Bowen DT, Frew ME, Hills R, Gale RE, Wheatley K, Groves MJ, Langabeer SE, Kottaridis PD, Moorman AV, Burnett AK, Linch DC
  Title
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.
  Journal
Blood 106:2113-9 (2005)
DOI:10.1182/blood-2005-03-0867
LinkDB

KEGG   VARIANT: 4893v1
Entry
4893v1                      Variant                                
Name
NRAS mutation
Type
Gain of function
Gene
NRAS  NRAS proto-oncogene, GTPase [KO:K07828]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
mutation G13V
ClinVar: 375876
dbSNP: rs121434596
COSM: 574
Variation
mutation G13D
ClinVar: 13901
dbSNP: rs121434596
COSM: 573
Variation
mutation Q61R
ClinVar: 13900 375873 376220
dbSNP: rs11554290 rs1057519695 rs1057519834
COSM: 584
Variation
mutation Q61H
ClinVar: 375871 373003
dbSNP: rs12193255 rs12193255
Variation
mutation G12D
ClinVar: 39648
dbSNP: rs12193237
COSM:564
Variation
mutation Q61K
ClinVar: 73058
dbSNP: rs121913254
COSM:580
Variation
mutation Q61L
ClinVar: 375872 375874
dbSNP: rs1057519695 rs11554290
Variation
mutation G12S
ClinVar: 177778
dbSNP: rs121913250
COSM: 563
Variation
mutation G13S
ClinVar: 376221
dbSNP: rs121434595
COSM: 571
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06271  Endometrial cancer
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
nt06530  PI3K signaling
Disease
H00003  Acute myeloid leukemia
H00014  Non-small cell lung cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00026  Endometrial cancer
H00032  Thyroid cancer
H00038  Melanoma
Reference
PMID:3103719
  Authors
Bos JL, Verlaan-de Vries M, van der Eb AJ, Janssen JW, Delwel R, Lowenberg B, Colly LP
  Title
Mutations in N-ras predominate in acute myeloid leukemia.
  Journal
Blood 69:1237-41 (1987)
Reference
PMID:2674680
  Authors
van 't Veer LJ, Burgering BM, Versteeg R, Boot AJ, Ruiter DJ, Osanto S, Schrier PI, Bos JL
  Title
N-ras mutations in human cutaneous melanoma from sun-exposed body sites.
  Journal
Mol Cell Biol 9:3114-6 (1989)
DOI:10.1128/MCB.9.7.3114
Reference
PMID:14695152
  Authors
Omholt K, Platz A, Kanter L, Ringborg U, Hansson J.
  Title
NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.
  Journal
Clin Cancer Res 9:6483-8 (2003)
Reference
PMID:24774510
  Authors
Takahashi N, Yamada Y, Taniguchi H, Fukahori M, Sasaki Y, Shoji H, Honma Y, Iwasa S, Takashima A, Kato K, Hamaguchi T, Shimada Y
  Title
Clinicopathological features and prognostic roles of KRAS, BRAF, PIK3CA and NRAS mutations in advanced gastric cancer.
  Journal
BMC Res Notes 7:271 (2014)
DOI:10.1186/1756-0500-7-271
LinkDB

DBGET integrated database retrieval system