KEGG   VARIANT: 3586v1
Entry
3586v1                      Variant                                
Name
IL10 mutation
Type
Loss of function
Gene
IL10  interleukin 10 [KO:K05443]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
promoter mutations
OmimVar: 124092
Network
nt06535  Efferocytosis
Disease
H00084  Graft-versus-host disease
H00630  Rheumatoid arthritis
Reference
PMID:14657427
  Authors
Lin MT, Storer B, Martin PJ, Tseng LH, Gooley T, Chen PJ, Hansen JA
  Title
Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.
  Journal
N Engl J Med 349:2201-10 (2003)
DOI:10.1056/NEJMoa022060
Reference
PMID:12847677
  Authors
Lard LR, van Gaalen FA, Schonkeren JJ, Pieterman EJ, Stoeken G, Vos K, Nelissen RG, Westendorp RG, Hoeben RC, Breedveld FC, Toes RE, Huizinga TW
  Title
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
  Journal
Arthritis Rheum 48:1841-8 (2003)
DOI:10.1002/art.11160
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