KEGG   VARIANT: 5925v1
Entry
5925v1                      Variant                                
Name
RB1 loss
Gene
RB1  RB transcriptional corepressor 1 [KO:K06618]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
Allelic loss on 13q
Network
nt06230  Cell cycle (cancer)
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06267  Small cell lung cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
Disease
H00004  Chronic myeloid leukemia
H00013  Small cell lung cancer
H00022  Bladder cancer
H00042  Glioma
H00048  Hepatocellular carcinoma
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535
Reference
  Authors
Bench AJ, Cross NC, Huntly BJ, Nacheva EP, Green AR
  Title
Myeloproliferative disorders.
  Journal
Best Pract Res Clin Haematol 14:531-51 (2001)
DOI:10.1053/beha.2001.0153
Reference
  Authors
Wada T, Louhelainen J, Hemminki K, Adolfsson J, Wijkstrom H, Norming U, Borgstrom E, Hansson J, Sandstedt B, Steineck G
  Title
Bladder cancer: allelic deletions at and around the retinoblastoma tumor suppressor gene in relation to stage and grade.
  Journal
Clin Cancer Res 6:610-5 (2000)
Reference
PMID:9036868
  Authors
Tamura K, Zhang X, Murakami Y, Hirohashi S, Xu HJ, Hu SX, Benedict WF, Sekiya T
  Title
Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancer.
  Journal
Reference
  Authors
Suriawinata A, Xu R
  Title
An update on the molecular genetics of hepatocellular carcinoma.
  Journal
Semin Liver Dis 24:77-88 (2004)
DOI:10.1055/s-2004-823102
Reference
PMID:7798888
  Authors
Hsia CC, Di Bisceglie AM, Kleiner DE Jr, Farshid M, Tabor E
  Title
RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus.
  Journal
J Med Virol 44:67-73 (1994)
DOI:10.1002/jmv.1890440113
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