KEGG   VARIANT: 5979v1
Entry
5979v1                      Variant                                

Name
RET fusion
Gene
RET  ret proto-oncogene [KO:K05126]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
CCDC6-RET fusion, inversion inv(10)(q11.2q21)
COSF: 1271
Variation
CCDC6-RET fusion, translocation t(10;10)(q11;q21)
COSF: 1271
Variation
NCOA4-RET fusion, inversion inv(10)(q11q11)
COSF: 1491
Variation
KIF5B-RET fusion, inversion inv(10)(p11q11)
COSF: 1231
Network
nt06210  ERK signaling
nt06266  Non-small cell lung cancer
nt06274  Thyroid cancer
  Element
N00008  RET fusion kinase to RAS-ERK signaling pathway
N10025  Tyrosine kinase inhibitor to RET fusion
Drug target
Pralsetinib: D11712<US>
Selpercatinib: D11713<US>
Reference
  Authors
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
  Title
RET fusions in solid tumors.
  Journal
Cancer Treat Rev 81:101911 (2019)
DOI:10.1016/j.ctrv.2019.101911
Reference
  Authors
Drilon A, Hu ZI, Lai GGY, Tan DSW
  Title
Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes.
  Journal
Nat Rev Clin Oncol 15:151-167 (2018)
DOI:10.1038/nrclinonc.2017.175
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Takeuchi K
  Title
Discovery Stories of RET Fusions in Lung Cancer: A Mini-Review.
  Journal
Front Physiol 10:216 (2019)
DOI:10.3389/fphys.2019.00216
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