KEGG ORTHOLOGY: K05126

ORTHOLOGY: K05126

Entry

K05126                      KO

Symbol

RET

Name

proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map05200

Pathways in cancer

map05216

Thyroid cancer

map05223

Non-small cell lung cancer

map05230

Central carbon metabolism in cancer

Disease

H00014

Non-small cell lung cancer

H00032

Thyroid cancer

H00247

Multiple endocrine neoplasia syndrome

H00910

Hirschsprung disease

H01510

Malignant paraganglioma

H01592

Medullary thyroid cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   04020 Calcium signaling pathway
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   04151 PI3K-Akt signaling pathway
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05230 Central carbon metabolism in cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
  09162 Cancer: specific types
   05216 Thyroid cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
   05223 Non-small cell lung cancer
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05126  RET; proto-oncogene tyrosine-protein kinase Ret
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  RET family
   K05126  RET; proto-oncogene tyrosine-protein kinase Ret

Genes

HSA:

5979(RET)

PTR:	100612888(RET)

PPS:	100994039(RET)

GGO:	101141559(RET)

PON:	100442682(RET)

PPYG:

129045306(RET)

NLE:	100602103(RET)

HMH:	116461332(RET)

SSYN:

129480838(RET)

MCC:	703466(RET)

MCF:	102135879(RET)

MTHB:

126962192

MNI:	105486614(RET)

CSAB:

103215755(RET)

CATY:

105571572(RET)

PANU:

101019433(RET)

TGE:	112631475(RET)

MLEU:

105534464(RET)

RRO:	104653928(RET)

RBB:	108513309(RET)

TFN:	117082351(RET)

PTEH:

111531334(RET)

CANG:

105520189(RET)

CJC:	100403596(RET)

SBQ:	101053966(RET)

CIMI:

108296697(RET)

ANAN:

105730226 105734317

CSYR:

103268658(RET)

MMUR:

105879007(RET)

LCAT:

123649762(RET)

PCOQ:

105818035(RET)

OGA:	100942216(RET)

MMU:	19713(Ret)

MCAL:

110295751(Ret)

MPAH:

110315801(Ret)

RNO:	24716(Ret)

MCOC:

116099474(Ret)

ANU:	117715252(Ret)

ASYL:

127679102(Ret)

MUN:	110558019(Ret)

CGE:	100772741(Ret)

MAUA:

101835994(Ret)

PROB:

127236239(Ret)

PLEU:

114689662(Ret)

MORG:

121441759(Ret)

MFOT:

126505488

AAMP:

119807136(Ret)

NGI:	103733801(Ret)

HGL:	101717565(Ret)

CPOC:

100733392(Ret)

CCAN:

109676742(Ret)

DORD:

105998878(Ret)

DSP:	122122245(Ret) 122124495

PLOP:

125344289(Ret)

NCAR:

124985472

MMMA:

107153442(Ret)

ITI:	101965571(Ret)

OCU:

100340710

OPI:	101535660(RET)

TUP:	102497228(RET)

GVR:	103605929(RET)

CFA:	403494(RET)

CLUD:

112672017(RET)

VVP:	112913604(RET)

VLG:	121485367(RET)

NPO:	129514783 129514833(RET) 129517742 129522975

AML:	100467317(RET)

UMR:	103668071(RET)

UAH:	113243095(RET)

UAR:	123800367(RET)

ELK:

111145007

LLV:

125085127

MPUF:

101682563(RET)

MNP:	132016602(RET)

MLK:	131828679(RET)

NVS:	122899273(RET)

ORO:	101372117(RET)

EJU:	114205290(RET)

ZCA:	113919740(RET)

MLX:	118023454(RET)

NSU:	110589447(RET)

LWW:	102727050(RET)

FCA:	101101086(RET)

PYU:	121036970(RET)

PCOO:

112854345(RET)

PBG:	122493003(RET)

PVIV:

125148237(RET)

LRUF:

124506146

LGF:	123576794(RET)

AJU:

106972131

PTG:	102951366(RET)

PPAD:

109264617(RET)

PUC:

125933341

PLEZ:

122202301(RET)

HHV:	120249234(RET)

BTA:	515924(RET)

BOM:	102284923(RET)

BIU:	109553788(RET)

BBUB:

102404389(RET)

BBIS:

104997328(RET)

CHX:	102172412(RET)

OAS:	101119787(RET)

BTAX:

128048891(RET)

CSUM:

138087235(RET)

ODA:	120860461 120865390

CCAD:

122446823(RET) 122453090

MREE:

136159709(RET)

OVR:	110128770(RET)

MBEZ:

129555834(RET)

SSC:	100155053(RET)

CFR:	102514431(RET)

CBAI:

105072689(RET)

CDK:	105092504(RET)

VPC:	102542942(RET)

BACU:

103006627(RET)

BMUS:

118883052(RET)

LVE:	103069161(RET)

OOR:	101288280(RET)

LALB:

132507181(RET)

DLE:	111163990(RET)

PCAD:

102984604(RET)

PSIU:

116742042(RET)

NASI:

112403824(RET)

ECB:	100146791(RET)

EPZ:	103550619(RET)

EAI:	106831339(RET)

MYB:	102238841(RET)

MYD:	102766212(RET)

MMYO:

118670212(RET)

MLF:	102420377(RET)

MDT:	132214757(RET)

MYUM:

139022077(RET)

PKL:	118719059(RET)

EFUS:

103292852(RET)

MNA:	107532547(RET)

DRO:	112305517(RET)

SHON:

118981054(RET)

AJM:	119038025(RET)

PDIC:

114497427(RET)

PHAS:

123821068(RET)

MMF:	118632108(RET)

PPAM:

129073176(RET)

HAI:	109395552(RET)

RFQ:	117036190(RET)

PALE:

102878133(RET)

PGIG:

120594602(RET)

PVP:	105309193(RET)

RAY:	107517623(RET)

MJV:	108392617(RET)

TOD:	119233871(RET)

SARA:

101547575(RET)

SFUM:

130029609(RET)

SETR:

125995054(RET)

LAV:	100672176(RET)

TMU:

101357522

ETF:	101651034(RET)

DNM:	101426197(RET)

MDO:	100016023(RET)

GAS:	123234327(RET)

SHR:	100927200(RET)

AFZ:

127551860

PCW:	110221483(RET)

TVP:	118828650(RET)

PBRV:

138146448(RET)

OAA:	100076319(RET)

TACU:

119925720(RET)

GGA:	396107(RET)

PCOC:

116234790(RET)

MGP:	100550243(RET)

CJO:	107315612(RET)

TPAI:

128077909(RET)

LMUT:

125693140(RET)

NMEL:

110399502(RET)

APLA:

101803164(RET)

ACYG:

106032512(RET)

CATA:

118246107(RET)

AFUL:

116491283(RET)

TGU:	100219340(RET)

LSR:	110468614(RET)

SCAN:

103814210(RET)

PMOA:

120507297(RET)

OTC:	121336116(RET)

PRUF:

121357411(RET)

ATRC:

139595510(RET)

GFR:	102042884(RET)

FAB:	101812108(RET)

OMA:	130254927(RET)

PHI:	102107711(RET)

PMAJ:

107207043(RET)

CCAE:

111931023(RET)

CCW:	104690242(RET)

CBRC:

103623743(RET)

ACOE:

138112344(RET)

ETL:	114062798(RET)

ZAB:	102067895(RET)

ZLE:	135449393(RET)

ACHL:

103802434(RET)

SVG:	106861226(RET)

MMEA:

130573039(RET)

HRT:	120756055(RET)

SATI:

136364304(RET)

CCIC:

134046438(RET)

FPG:	101922216(RET)

FCH:	102048122(RET)

CCRI:

104161662(RET)

NNT:	104411708(RET)

SHAB:

115607825(RET)

ACUN:

113483380(RET)

TALA:

104364998(RET)

ACHC:

115348153(RET)

HALD:

104321876(RET)

HLE:	104831991(RET)

AGEN:

126042563

HHAR:

128147017(RET)

GCL:

127017854

CSTI:

104554622(RET)

LDI:	104351977(RET)

MNB:

103780502

DPUB:

104298836(RET)

PPUS:

135176360(RET)

AVIT:

104276495(RET)

BRHI:

104493021

EGZ:	104128999(RET)

NNI:	104015433(RET)

PCRI:

104023771(RET)

PADL:

103924216(RET)

AFOR:

103898550(RET)

FGA:	104079463(RET)

GSTE:

104255646(RET)

CLV:	102083695(RET)

MUI:	104541230(RET)

PGUU:

104469888(RET)

PLET:

104620848

EHS:	104503351(RET)

CMAC:

104479784(RET)

CUCA:

104063055(RET)

TEO:	104377668(RET)

BREG:

104638340

OHA:	104333636(RET)

ACAR:

104530380(RET)

CPEA:

104389173(RET)

CVF:	104286037(RET)

RTD:	128911453(RET)

AAM:	106498889(RET)

AROW:

112973047(RET)

NPD:

112945067

TGT:	104576517(RET)

DNE:	112993309(RET)

SCAM:

104152622(RET)

ASN:	102371199(RET)

AMJ:	102573157(RET)

CPOO:

109324217(RET)

GGN:	109287344(RET)

PSS:	102459127(RET)

CMY:	102940624(RET)

CCAY:

125639370(RET)

DCC:	119859399(RET)

CPIC:

101938031(RET)

TST:	117880563(RET)

CABI:

116828262(RET)

MRV:	120369304(RET)

ACS:	100563549(ret)

ASAO:

132771276(RET)

PVT:	110083673(RET)

SUND:

121927379(RET)

PBI:	103058664(RET)

PMUR:

107293255(RET)

CTIG:

120306829(RET)

TSR:	106555050(RET)

PGUT:

117669197 132712657(RET)

APRI:

131201264(RET)

PTEX:

113445411(RET)

NSS:	113419135(RET)

VKO:	123018201(RET)

PMUA:

114597095(RET)

PRAF:

128413774(RET)

ZVI:	118096361(RET)

HCG:	128351802(RET)

GJA:	107122192(RET)

STOW:

125438408(RET)

EMC:	129332012(RET)

XLA:	108696288(ret.L) 373625(ret.S)

XTR:	100495902(ret)

NPR:	108786609(RET)

RTEM:

120909054(RET)

BBUF:

121004860(RET)

BGAR:

122942424(RET)

PWL:	138300603(RET)

MUO:	115471278(RET)

GSH:	117359969(RET)

DRE:	30512(ret)

SRX:	107726966 107743501

SANH:

107655443 107666456

SGH:	107559333(ret) 107601801

CCAR:

109078964 109091940

CAUA:

113056958 113112663

CGIB:

127970765 128026196

PTET:

122356928(ret)

LROH:

127175499(ret)

OMC:	131552326(ret)

PPRM:

120473231(ret)

RKG:	130089631(ret)

MAMB:

125276928(ret)

CIDE:

127524401

CERY:

137020566(ret)

MASI:

127412272 127414257

TROS:

130559028(ret)

TDW:	130431768(ret)

MANU:

129416335(ret)

PDAB:

135787025(ret)

IPU:

108262651

IFU:	128605774(ret)

PHYP:

113537802(ret)

SMEO:

124378199(ret)

TFD:	113636332(ret)

TVC:	132847389(ret)

CGAR:

128529214(ret)

NGRA:

132888699(ret)

TRN:	134314709(ret)

AMEX:

103028663(ret)

CMAO:

118810504(ret)

EEE:	113585232(ret)

CHAR:

105890844(ret)

SPIL:

134063654(ret)

TRU:	101070188(ret)

TFS:	130534087(ret)

TNG:	GSTEN00024538G001

LCO:	104921882(ret)

NCC:	104952732(ret)

TBEN:

117499604(ret)

CGOB:

115020027(ret)

PGEO:

117459360(ret)

GACU:

117551519(ret)

EMAC:

134858913(ret)

ELY:	117248682(ret)

EFO:	125903140(ret)

PLEP:

121954725(ret)

SLUC:

116039377(ret)

ECRA:

117960079(ret)

ESP:	116683575(ret)

PFLV:

114572052(ret)

GAT:	120820232(ret)

PPUG:

119214572(ret)

AFB:	129092095(ret)

CLUM:

117744147(ret)

PSWI:

130207538(ret)

CANA:

137780175(ret)

CVE:	137884375(ret)

MSAM:

119917613(ret)

SCHU:

122884854(ret)

CUD:	121511238(ret)

SPUL:

138588196(ret)

LMIX:

132975992(ret)

ALAT:

119033746(ret)

ASTR:

137603954(ret)

MZE:	101475370 112434355

ONL:	100702608(ret)

OAU:	116318763(ret)

OLA:	101156037(ret)

OML:	112161593(ret)

CSAI:

133464072(ret)

XMA:	102237488(ret)

XCO:	114137568(ret)

XHE:	116713771(ret)

PRET:

103477116(ret)

PFOR:

103148242(ret)

PLAI:

106951787(ret)

PMEI:

106920941(ret)

GAF:	122842268(ret)

PPRL:

129352639(ret)

CVG:	107088598(ret)

CTUL:

119782899(ret)

GMU:	124858614(ret)

NFU:	107375369(ret)

KMR:	108240623(ret)

ALIM:

106525613(ret)

NWH:	119417522(ret)

AOCE:

111573084(ret)

EJA:	138195593(ret)

BFRE:

138616012(ret)

MCEP:

125018405(ret)

CSEM:

103387460(ret)

POV:	109636804(ret)

SSEN:

122782182(ret)

HHIP:

117775765(ret)

HSP:	118119412(ret)

PPLT:

128453791(ret)

SMAU:

118284162(ret)

LCF:

108886252

SDU:	111220596(ret)

SLAL:

111669539(ret)

XGL:	120796812(ret)

HCQ:	109523240(ret)

SSCV:

125978423(ret)

SBIA:

133509596(ret)

PEE:	133409412(ret)

PTAO:

133485353(ret)

BPEC:

110162334(ret)

MALB:

109958407(ret)

BSPL:

114870726(ret)

SJO:	128372417(ret)

SSCO:

133991517(ret)

GMH:	115560103(ret)

SASA:

106576823 106604566

STRU:

115153007 115194005

OTW:	112252648 112252802(ret)

OMY:	110502270 110526355(ret)

OGO:	124038110 124041440(ret)

ONE:	115113390 115135308

OKI:	109889771 109899062

OKE:	118369505 118402076

OMM:	135510834 135512480

SALP:

111952048 111978543

SNH:	120017384(ret) 120045844

CCLU:

121553399(ret) 121568845

ELS:	105028647(ret)

SFM:	108932773(ret)

PKI:	111848989(ret)

AANG:

118217945(ret)

AROT:

135244772(ret)

CCOG:

133118392(ret)

LOC:	102697421(ret)

PSPA:

121325980(ret)

ARUT:

117417619(ret)

PSEX:

120529236(ret)

LCM:	102358285(RET)

CMK:	103182663(ret)

RTP:	109921507(ret)

CPLA:

122541730(ret)

HOC:	132835095(ret)

LERI:

129712934(ret)

PMRN:

116951076(RET)

LRJ:	133354448(RET)

CIN:	100182804 100186039

SCLV:

120332675

SPU:	105437406 105444549 577861 586619

LPIC:

129282051

APLC:

110977552 110985025 110987129

ARUN:

117303982

SKO:	100369916 102804897

PFLL:

139122440

DME:	Dmel_CG14396(Ret)

DER:

6548796

DSE:

6618258

DSI:	Dsimw501_GD21645(Dsim_GD21645)

DYA:	Dyak_GE12994

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17995

DAZ:

108610714

DNV:

115562752

DHE:

111599187

DVI:	6628028(Ret)

CCAT:

101456740 101462539

BOD:	106615713 106621157

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135952223(Ret)

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AAG:	110680434 5568762

AALB:

109420544 109621254

ASUA:

134212267

CQU:	CpipJ_CPIJ000502

CPII:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139107317(Ret)

HST:

DQU:

CFO:

FEX:

PMEC:

138944684(Ret)

LHU:	105668422(Ret)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:	107038031 107038798

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124214584(Ret)

NFB:

NLO:

NVG:

AROA:

TCA:	657748(ret)

TMOL:

138126844(Ret)

DPA:

ESIM:

EFOR:

SOY:

AGRG:

CSET:

HAXR:

AGB:

LDC:	111502550 111511317

DVV:

NVL:

APLN:

PPYR:

OTU:	111421624 111425271

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

CLEC:

HHAL:

106683380(Ret)

NLU:

111057641

HVI:

124363590

MQU:	128989262 128989542

PHU:	Phum_PHUM495270

FOC:	113211815 113212347

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DMK:

AFRA:

PJA:

PCHN:

HAME:

PCLA:

123755818(Ret)

PTRU:

ESN:

MNZ:

MRJ:

PORN:

139758666(Ret)

HAZT:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:	111266387 111271643

CSCU:

111620592 111621481 111621482 111622754

CVS:	136979384 136986228

PTEP:

107447239

ABRU:

129962693 129975046

UDV:

129224784

SDM:	118189676 118190652

LPOL:

106457965 106458605 106464932 106468581 106470728

PVUL:

126811809

BGT:	106054275 106056831 106065621

GAE:	121370023 121379467 121383165

HRF:	124119095 124132410 124145276 124150005

HRJ:	124275614 124283699 124286728

HASI:

137285277

HCRA:

139469393

CRG:	105320394 105324638 105330510

CANU:

128166783

CVN:

111122270

OED:

125670572

MYI:	110461040 110466000

PMAX:

117322864 117324338 117339136

AIRR:

138323126

MMER:

123546441 123564824

MAEA:

128243079

OBI:	106879436 106879437 106883560

OSN:	115224493 115227037 115229190

LJP:

135467336

LAK:	106152770 106154548 106155165 106171307

SMM:	Smp_175590

LLON:

135493180

EPA:

110251418

ATEN:

116295097 116295551 116295558 116299340 116300124 116300134 116300137

ADF:	107328041 107328278 107341295 107344246 107346416 107355358

AMIL:

114947144 114948672 114956152 114963035 114967418 114969236 114970158 114974412

MFOO:

137981956 137983359

PDAM:

113670427 113673162 113676074 113676584 113679283 113681729

SPIS:

111325544 111329741 111329799 111332573 111337283 111338500 111338502 111338863 111340958 111340993 111341760 111344722 111346136 111346412 111347582

DGT:	114526994 114538351

XEN:	124441362 124457361 124458692

HMG:

100209956

» show all

Reference

PMID:15331579

Authors

Santoro M, Melillo RM, Carlomagno F, Vecchio G, Fusco A

Title

Minireview: RET: normal and abnormal functions.

Journal

Endocrinology 145:5448-51 (2004)
DOI:10.1210/en.2004-0922

Reference

PMID:11114739

Authors

Jhiang SM

Title

The RET proto-oncogene in human cancers.

Journal

Oncogene 19:5590-7 (2000)
DOI:10.1038/sj.onc.1203857

LinkDB

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