KEGG ORTHOLOGY: K12173

ORTHOLOGY: K12173

Entry

K12173                      KO

Symbol

BRE, BRCC45

Name

BRCA1-A complex subunit BRE

Pathway

map03440

Homologous recombination

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
   03036 Chromosome and associated proteins
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
   03400 DNA repair and recombination proteins
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   BRCC complex
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   BRISC complex
    K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    BRISC complex
     K12173  BRE, BRCC45; BRCA1-A complex subunit BRE
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-A complex
     K12173  BRE, BRCC45; BRCA1-A complex subunit BRE

Genes

HSA:	9577(BABAM2)

PTR:	459112(BABAM2)

PPS:	100972553(BABAM2)

GGO:	101154385(BABAM2)

PON:	100171610(BABAM2)

PPYG:

129030054(BABAM2)

NLE:	100583596(BABAM2) 100600309

HMH:	116480498(BABAM2)

SSYN:

129468091(BABAM2)

MCC:	702365(BABAM2)

MCF:	102138281(BABAM2)

MTHB:

126933832

MNI:	105479908(BABAM2)

CSAB:

103220580(BRE)

CATY:

105578441(BRE)

PANU:

101010417(BABAM2)

TGE:	112636993(BABAM2)

MLEU:

105533960(BRE)

RRO:	104668473(BABAM2)

RBB:	108532734(BRE)

TFN:	117062538(BABAM2)

PTEH:

111546008(BABAM2)

CANG:

105521949(BRE)

CJC:	100396239(BABAM2)

SBQ:	101050623(BRE)

CIMI:

108315978(BABAM2)

ANAN:

105733081(BABAM2)

CSYR:

103275348(BABAM2)

MMUR:

105884426(BRE)

LCAT:

123636750(BABAM2)

PCOQ:

105816873(BRE)

OGA:	100962153(BABAM2)

MMU:	107976(Babam2)

MCAL:

110294044(Babam2)

MPAH:

110323987(Babam2)

RNO:	362704(Babam2)

MCOC:

116080926(Babam2)

ANU:	117701723 117717159(Babam2)

ASYL:

127687569(Babam2)

MUN:	110559904(Babam2)

CGE:	100756206(Babam2)

MAUA:

101827674(Babam2)

PROB:

127220105(Babam2)

PLEU:

114696301(Babam2)

MORG:

121432925(Babam2)

MFOT:

126494595

AAMP:

119808175(Babam2)

NGI:	103730232(Bre)

HGL:	101696560(Bre)

CPOC:

100725666(Babam2)

CCAN:

109679358(Bre)

DORD:

105983758(Bre)

DSP:	122122520(Babam2)

PLOP:

125356608(Babam2)

NCAR:

124963540

MMMA:

107137398(Babam2)

ITI:	101962655(Babam2)

OCU:	100347469(BABAM2)

OPI:	101521697(BABAM2)

TUP:	102500385(BRE)

GVR:	103589565(BRE)

CFA:	475711(BABAM2)

CLUD:

112664602(BABAM2)

VVP:	112933000(BABAM2)

VLG:	121490895(BABAM2)

NPO:	129510745(BABAM2)

AML:	100473598(BABAM2)

UMR:	103671625(BABAM2)

UAH:	113271368(BABAM2)

UAR:	123799884(BABAM2)

ELK:

111139277

LLV:

125109444

MPUF:

101680577(BRE)

MNP:	132021240(BABAM2)

MLK:	131840600(BABAM2)

NVS:	122915201(BABAM2) 122917788

ORO:	101373974(BRE)

EJU:	114205852(BABAM2)

ZCA:	113938636(BABAM2)

MLX:	118007719(BABAM2)

NSU:	110587168(BABAM2)

LWW:	102749783(BABAM2)

FCA:	101093767(BABAM2)

PYU:	121044280(BABAM2)

PCOO:

112864052(BABAM2)

PBG:	122497311(BABAM2)

PVIV:

125162238(BABAM2)

LRUF:

124504381

LGF:	123581303(BABAM2)

AJU:	106967868(BABAM2)

PTG:	102950201(BRE)

PPAD:

109266563(BRE)

PLEZ:

122216481(BABAM2)

HHV:	120235936(BABAM2)

BTA:	614152(BABAM2)

BOM:	102267897(BABAM2)

BIU:	109566264(BRE)

BBUB:

102409724(BABAM2)

BBIS:

104989097(BRE)

CHX:	102172635(BRE)

OAS:	101121412(BABAM2)

BTAX:

128055405(BABAM2)

CSUM:

138077560(BABAM2)

ODA:	120851535(BABAM2)

CCAD:

122441919(BABAM2)

MREE:

136162767(BABAM2)

OVR:	110132759(BABAM2)

MBEZ:

129539027(BABAM2)

SSC:	100623966(BABAM2)

CFR:	102519973(BABAM2)

CBAI:

105063811(BRE)

CDK:	105098560(BABAM2)

VPC:	102531655(BABAM2)

BACU:

102999220(BRE)

BMUS:

118906432(BABAM2)

LVE:	103079097(BRE)

OOR:	101278966(BABAM2)

LALB:

132531771(BABAM2)

DLE:	111174934(BABAM2)

PCAD:

102994105(BABAM2)

PSIU:

116764315(BABAM2)

NASI:

112412749(BABAM2)

ECB:	100054872(BABAM2)

EPZ:	103549481(BABAM2)

EAI:	106837064(BABAM2)

MYB:	102249351(BRE)

MYD:	102761896(BRE)

MMYO:

118669152(BABAM2)

MLF:	102422512(BABAM2)

MDT:	132213518(BABAM2)

MYUM:

139019783(BABAM2)

PKL:	118717165(BABAM2)

EFUS:

103305501(BABAM2)

MNA:	107534641(BRE)

DRO:	112297797(BABAM2)

SHON:

119001317(BABAM2)

AJM:	119050360(BABAM2)

PDIC:

114499761(BABAM2)

PHAS:

123822480(BABAM2)

MMF:	118631080(BABAM2)

PPAM:

129066675(BABAM2)

HAI:	109391088(BRE)

RFQ:	117033380(BABAM2)

PALE:

102880922(BABAM2)

PGIG:

120621822(BABAM2)

PVP:	105299129(BABAM2)

RAY:	107511170(BABAM2)

MJV:	108387081(BABAM2)

TOD:	119259441(BABAM2)

SARA:

101551519(BRE)

SFUM:

130032003(BABAM2)

SETR:

126023858(BABAM2)

LAV:	100659430(BABAM2)

TMU:

101344382

ETF:	101654433(BABAM2)

DNM:	101443897(BABAM2)

MDO:	100026430(BRE)

GAS:	123237065(BABAM2)

SHR:	100932958(BABAM2)

AFZ:

127548707

PCW:	110206449(BABAM2)

TVP:	118844670(BABAM2)

PBRV:

138149152(BABAM2)

OAA:	100076880(BABAM2)

TACU:

119932246(BABAM2)

GGA:	421417(BABAM2)

PCOC:

116229762(BABAM2)

MGP:	100546696(BABAM2)

CJO:	107311138(BABAM2)

TPAI:

128090140(BABAM2)

LMUT:

125689159(BABAM2)

NMEL:

110396807(BABAM2)

APLA:

101793627(BABAM2)

ACYG:

106029773(BABAM2)

CATA:

118255543(BABAM2)

AFUL:

116487200(BABAM2)

TGU:	100231620(BABAM2)

LSR:	110482766(BABAM2)

SCAN:

103817265(BABAM2)

PMOA:

120496857(BABAM2)

OTC:	121340626(BABAM2)

PRUF:

121358832(BABAM2)

ATRC:

139590410(BABAM2)

GFR:	102032483(BRE)

FAB:	101809786(BRE)

OMA:	130251933(BABAM2)

PHI:	102102908(BRE)

PMAJ:

107201457(BABAM2)

CCAE:

111927628(BABAM2)

CCW:	104685702(BABAM2)

CBRC:

103622735(BRE)

ACOE:

138107922(BABAM2)

ETL:

114064851

ZAB:	102067355(BABAM2)

ZLE:	135445833(BABAM2)

ACHL:

103805648(BRE)

SVG:	106853794(BRE)

MMEA:

130576464(BABAM2)

HRT:	120750496(BABAM2)

SATI:

136359427(BABAM2)

CCIC:

134042127(BABAM2)

FPG:	101916479(BRE)

FCH:	102058139(BABAM2)

CCRI:

104168939(BRE)

SHAB:

115613527(BABAM2)

ACUN:

113478791(BABAM2)

TALA:

104363686(BABAM2)

ACHC:

115350127(BABAM2)

HALD:

104319529(BRE)

HLE:	104837409(BRE)

AGEN:

126052699

HHAR:

128150291(BABAM2)

GCL:

127014320

CSTI:

104560002(BRE)

LDI:	104346565(BRE)

MNB:

103779175

DPUB:

104303712(BRE)

PPUS:

135183394(BABAM2)

BRHI:

104500393(BRE)

EGZ:	104135631(BABAM2)

NNI:	104021495(BRE)

PCRI:

104031256(BRE)

PCAO:

104043148(BRE)

PADL:

103914292(BRE)

AFOR:

103902651(BRE)

CBOY:

140649471(BABAM2)

CLV:	102098832(BABAM2)

MUI:	104540869(BRE)

PGUU:

104467865(BRE)

PLET:

104617894(BRE)

EHS:	104512681(BRE)

CUCA:

104062219(BABAM2)

TEO:	104380203(BRE)

BREG:

104641657 104642173

OHA:	104326665(BRE)

CPEA:

104395245(BRE)

CVF:	104282549(BRE)

RTD:	128907557(BABAM2)

CRID:

134512855(BABAM2)

AAM:	106485490(BRE)

AROW:

112962900(BABAM2)

NPD:	112953210(BABAM2)

TGT:	104565084(BRE)

DNE:	112995922(BABAM2)

SCAM:

104144974(BRE)

ASN:

102371325

AMJ:	102566503(BRE)

CPOO:

109319813(BRE)

GGN:	109304349(BRE)

PSS:	102443885(BABAM2)

CMY:	102948018(BABAM2)

CCAY:

125633736(BABAM2)

DCC:	119853308(BABAM2)

CPIC:

101945264(BABAM2)

TST:	117874547(BABAM2)

CABI:

116830624(BABAM2)

MRV:	120401213(BABAM2)

ACS:	100563067(bre)

ASAO:

132761335(BABAM2)

PVT:	110078704(BABAM2)

SUND:

121935490(BABAM2)

PBI:	103058066(BABAM2)

PMUR:

107288069(BABAM2)

CTIG:

120305350(BABAM2)

TSR:	106544135(BRE)

PGUT:

117671805(BABAM2)

APRI:

131188023(BABAM2)

PTEX:

113433193(BABAM2)

NSS:	113421316(BABAM2)

VKO:	123028305(BABAM2)

PMUA:

114594574(BABAM2)

PRAF:

128411022(BABAM2)

ZVI:	118083257(BABAM2)

HCG:	128349525(BABAM2)

GJA:	107109492(BRE)

STOW:

125442298(BABAM2)

EMC:	129337997(BABAM2)

XLA:	444077(babam2.L)

XTR:	448242(babam2)

NPR:	108786339(BRE)

RTEM:

120938137(BABAM2)

BBUF:

120999366(BABAM2)

BGAR:

122923725(BABAM2)

PWL:	138296786(BABAM2)

MUO:	115465432(BABAM2)

GSH:	117357999(BABAM2)

DRE:	550474(babam2)

SRX:	107726087 107737444

SANH:

107656747 107697534

SGH:	107553730 107566109(bre)

CCAR:

109071993 109107309(babam2)

CAUA:

113060452 113117038

CGIB:

127975851 128031745

PTET:

122334877(babam2)

LROH:

127179645(babam2)

OMC:	131523051(babam2)

PPRM:

120464120(babam2)

RKG:	130085152(babam2)

MAMB:

125269158(babam2)

CIDE:

127499148

CERY:

137007001(babam2)

MASI:

127410973

TROS:

130560500

TDW:	130437397(babam2)

MANU:

129417250(babam2)

PDAB:

135778238(babam2)

IPU:	108270148(babam2)

IFU:	128612842(babam2)

PHYP:

113545005(babam2)

SMEO:

124389640(babam2)

TFD:	113656926(babam2)

TVC:	132852150(babam2)

CGAR:

128535701(babam2)

NGRA:

132894635(babam2)

TRN:	134324885(babam2)

AMEX:

103039594(babam2)

CMAO:

118823803(babam2)

EEE:	113572149(babam2)

CHAR:

105888547(babam2)

SPIL:

134068203(babam2)

TRU:	101061624(babam2)

TFS:	130539659(babam2)

TNG:	GSTEN00034746G001 GSTEN00034747G001

LCO:	104923324(babam2)

NCC:

104968080

TBEN:

117486697(babam2)

CGOB:

115027882(babam2)

PGEO:

117467610(babam2)

GACU:

117539698(babam2)

EMAC:

134881894(babam2)

ELY:	117266612(babam2)

EFO:	125901082(babam2)

PLEP:

121953734(babam2)

SLUC:

116065722(babam2)

ECRA:

117935327(babam2)

ESP:	116670688(babam2)

PFLV:

114546374(babam2)

GAT:	120832627(babam2)

PPUG:

119227340(babam2)

AFB:	129103109(babam2)

CLUM:

117725473(babam2)

PSWI:

130201353(babam2)

CANA:

137787745(babam2)

CVE:	137877774(babam2) 137888660

MSAM:

119909823(babam2)

SCHU:

122861475(babam2)

CUD:	121526782(babam2)

SPUL:

138591369(babam2)

LMIX:

132993042(babam2)

ALAT:

119034424(babam2)

ASTR:

137610655(babam2)

MZE:	101469404(babam2)

ONL:	100693521(babam2)

OAU:	116315208(babam2)

OLA:	101162332(babam2)

OML:	112146939(babam2)

CSAI:

133462036(babam2)

XMA:	102218686(babam2)

XCO:	114134541(babam2)

XHE:	116709373(babam2)

PRET:

103458681(bre)

PFOR:

103154202(bre)

PLAI:

106935054(bre)

PMEI:

106929504(bre)

GAF:	122845609(babam2)

PPRL:

129365576(babam2)

CVG:	107091103(bre)

CTUL:

119783580(babam2)

GMU:	124855330(babam2)

NFU:	107395957(bre)

KMR:	108245070(babam2)

ALIM:

106518675(bre)

NWH:	119427774(babam2)

AOCE:

111571190(babam2)

EJA:	138205179(babam2)

BFRE:

138630370(babam2)

MCEP:

125023265(babam2)

CSEM:

103387649(bre)

POV:	109627768(bre)

SSEN:

122783174(babam2)

SSOE:

131444624(babam2)

HHIP:

117756199(babam2)

HSP:	118115922(babam2)

PPLT:

128450405(babam2)

SMAU:

118285836(babam2)

LCF:	108896159(babam2)

SDU:	111225512(babam2)

SLAL:

111656298(babam2)

XGL:	120795044(babam2)

HCQ:	109524307(bre)

SSCV:

125981422(babam2)

SBIA:

133512979(babam2)

PEE:	133412480(babam2)

PTAO:

133487429(babam2)

BPEC:

110155546(babam2)

ENY:	140370758(babam2)

BSPL:

114849104(babam2)

SJO:	128374820(babam2)

SSCO:

134000558(babam2)

GMH:	115543421(babam2)

SASA:

106610606(bre)

STRU:

115162617(babam2)

OTW:	112255717(babam2)

OMY:	110505232(babam2)

OGO:	124046235(babam2)

ONE:	115138253(babam2)

OKI:	109903836(babam2)

OKE:	118368569(babam2)

OMM:	135526139(babam2)

OCLA:

139383749

SALP:

112068334 112068772(babam2)

SNH:	120023087(babam2)

CCLU:

121539656 121545181(babam2)

ELS:	105023284(babam2)

OEP:	134026362(babam2)

SFM:	108922568(babam2)

PKI:	111834111(babam2)

AANG:

118220467(babam2)

AROT:

135236821(babam2)

CCOG:

133140767(babam2)

LOC:	102696236(bre)

PSPA:

121316216(babam2)

ARUT:

117403128 117410668

PSEX:

120526393(babam2)

CMK:	103189612(babam2)

RTP:	109912372(babam2)

CPLA:

122548495(babam2)

HOC:	132836673(babam2)

LERI:

129694335(babam2)

PMRN:

116941553(BABAM2)

LRJ:	133344271(BABAM2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

TLN:	139820528 139824502

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

TPRE:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:	111413695 139431891

BMOR:

101740057

BMAN:

114253449

MSEX:

115453345

DPL:	KGM_207547

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CCRN:

BTAB:

DCI:

NLU:	111049053 120351067 120355521

FOC:

TPAL:

ZNE:

CSEC:

PAME:

BROR:

IEL:

HAMR:

DPX:	DAPPUDRAFT_308966

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

CVS:

PTEP:

ABRU:

129958079 129958081 129958082 129981550

UDV:

129223423

SDM:	118198329 118200030

LPOL:

106469058

TSP:

Tsp_03084

HRO:	HELRODRAFT_193162

LGI:	LOTGIDRAFT_236527

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106177228 106180822

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

TAD:	TRIADDRAFT_52680

AQU:	105313757 105313973 109580106

ATH:

AT5G42470

ALY:

9301589

CRB:

17876620

CSAT:

104725243 104760722 104771365

EUS:	EUTSA_v10003229mg

BRP:

103828022

BNA:	106349523 111205105

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10001496mg

PVY:

MINC:

TCC:

GRA:

GHI:	107918164 121205059

GAB:

108467899

HSYR:

120145828 120160186 120195279

DZI:	111312811 111315296

EGR:	104448850 104449561

RARG:

115738629

GMX:	100794341 100814793

GSJ:	114367914 114386283

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:	101490421 101499060

PSAT:

127075747

VVO:	131622484 131625716

LJA:

130725909

ADU:

107483115

AIP:

107638805

AHF:	112741425 112796129

LANG:

109334892

PCIN:

129317204

QSA:	O6P43_016276 O6P43_018688

FVE:

101305530

AANS:

126783148

RCN:	112170421 112198856

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103413829 103420862

MSYL:

PXB:

PCOX:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110655881 110673832

MESC:

110616185

POP:	7490649 7493974

PEU:	105128868 105140092

PALZ:

118052698 118062027

PNZ:	133690880 133695169

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:	119999876 120009060

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107791086 107815757

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121778513 121781244 121807179

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130768029 130776054 130783917

BVG:

104905121

SOE:

110786350

CQI:	110686433 110733420

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119329433 119337209

TAES:

123148295 123157368 123165304

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

136520511 136520524 136528535

SITA:

101758790

SVS:	117851325 117851328

PVIR:

PHAI:

PAUA:

PDA:

EGU:

MUS:

ZOF:	121967457 122052687

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_178578 SELMODRAFT_445185

PPP:

112281548

SRE:	PTSG_06607

NGR:	NAEGRDRAFT_69708

GTT:	GUITHDRAFT_100349

» show all

Reference

PMID:14636569

Authors

Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R

Title

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.

Journal

Mol Cell 12:1087-99 (2003)
DOI:10.1016/S1097-2765(03)00424-6

Sequence

[hsa:9577]

Reference

PMID:15465831

Authors

Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL

Title

A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.

Journal

J Biol Chem 279:52106-16 (2004)
DOI:10.1074/jbc.M408678200

Sequence

[hsa:9577]

LinkDB

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