KEGG PATHWAY: lavi03070

PATHWAY: lavi03070

Entry

lavi03070                   Pathway

Name

Bacterial secretion system - Novilysobacter avium

Description

Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.

Class

Environmental Information Processing; Membrane transport

Pathway map

lavi03070

Bacterial secretion system

Other DBs

GO:	0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953

Organism

Novilysobacter avium [GN:lavi]

Gene

INQ42_00265

[KO:K11904]

INQ42_00470

secB; protein-export chaperone SecB [KO:K03071]

INQ42_00530

tssM; type VI secretion system membrane subunit TssM [KO:K11891]

INQ42_00745

[KO:K11892]

INQ42_00755

tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]

INQ42_00775

[KO:K11903]

INQ42_00795

tssH; type VI secretion system ATPase TssH [KO:K11907]

INQ42_02040

[KO:K12340]

INQ42_02250

gspE; type II secretion system ATPase GspE [KO:K02454] [EC:7.4.2.8]

INQ42_02255

[KO:K02455]

INQ42_02260

gspG; type II secretion system major pseudopilin GspG [KO:K02456]

INQ42_02265

[KO:K02457]

INQ42_02270

[KO:K02458]

INQ42_02275

[KO:K02459]

INQ42_02280

[KO:K02460]

INQ42_02285

[KO:K02461]

INQ42_02290

[KO:K02462]

INQ42_02300

gspD; type II secretion system secretin GspD [KO:K02453]

INQ42_02495

secE; preprotein translocase subunit SecE [KO:K03073]

INQ42_02660

secY; preprotein translocase subunit SecY [KO:K03076]

INQ42_04360

ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]

INQ42_04530

[KO:K03224] [EC:7.4.2.8]

INQ42_04535

[KO:K03223]

INQ42_04545

sctJ; type III secretion inner membrane ring lipoprotein SctJ [KO:K03222]

INQ42_04565

sctV; type III secretion system export apparatus subunit SctV [KO:K03230]

INQ42_04585

sctQ; type III secretion system cytoplasmic ring protein SctQ [KO:K03225]

INQ42_04590

[KO:K03226]

INQ42_04595

sctS; type III secretion system export apparatus subunit SctS [KO:K03227]

INQ42_04600

sctT; type III secretion system export apparatus subunit SctT [KO:K03228]

INQ42_04605

sctU; type III secretion system export apparatus subunit SctU [KO:K03229]

INQ42_04715

ftsY; signal recognition particle-docking protein FtsY [KO:K03110]

INQ42_04775

yajC; preprotein translocase subunit YajC [KO:K03210]

INQ42_04780

secD; protein translocase subunit SecD [KO:K03072]

INQ42_04785

secF; protein translocase subunit SecF [KO:K03074]

INQ42_07980

secG; preprotein translocase subunit SecG [KO:K03075]

INQ42_08200

[KO:K11912] [EC:2.7.11.1]

INQ42_08545

[KO:K12340]

INQ42_09830

[KO:K11904]

INQ42_09895

secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]

INQ42_10685

[KO:K02455]

INQ42_10690

tadA; Flp pilus assembly complex ATPase component TadA [KO:K02454] [EC:7.4.2.8]

INQ42_12035

tatA; Sec-independent protein translocase subunit TatA [KO:K03116]

INQ42_12040

tatB; twin-arginine translocase subunit TatB [KO:K03117]

INQ42_12045

tatC; twin-arginine translocase subunit TatC [KO:K03118]

INQ42_12825

yidC; membrane protein insertase YidC [KO:K03217]

Compound

C00002

ATP

Reference

PMID:11173102

Authors

Kim JF.

Title

Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.

Journal

Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2

Reference

PMID:11309112

Authors

Plano GV, Day JB, Ferracci F.

Title

Type III export: new uses for an old pathway.

Journal

Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x

Reference

PMID:11413015

Authors

Gauthier A, Finlay BB.

Title

Bacterial pathogenesis: the answer to virulence is in the pore.

Journal

Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8

Reference

PMID:10047550

Authors

Burns DL.

Title

Biochemistry of type IV secretion.

Journal

Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6

Reference

PMID:10920394

Authors

Christie PJ, Vogel JP.

Title

Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.

Journal

Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3

Reference

PMID:11309113

Authors

Christie PJ.

Title

Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.

Journal

Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x

Reference

PMID:10481178

Authors

Nunn D.

Title

Bacterial type II protein export and pilus biogenesis: more than just homologies?

Journal

Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7

Reference

PMID:11309111

Authors

Sandkvist M.

Title

Biology of type II secretion.

Journal

Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x

Reference

PMID:11349009

Authors

Sandkvist M.

Title

Type II secretion and pathogenesis.

Journal

Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001

Reference

PMID:15546664

Authors

Delepelaire P

Title

Type I secretion in gram-negative bacteria.

Journal

Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001

Reference

PMID:18406342

Authors

Hazes B, Frost L

Title

Towards a systems biology approach to study type II/IV secretion systems.

Journal

Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011

Reference

PMID:16448494

Authors

Johnson TL, Abendroth J, Hol WG, Sandkvist M

Title

Type II secretion: from structure to function.

Journal

FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x

Reference

PMID:15546665

Authors

Filloux A

Title

The underlying mechanisms of type II protein secretion.

Journal

Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003

Reference

PMID:19396170

Authors

Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC

Title

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.

Journal

Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603

Reference

PMID:15590783

Authors

Ghosh P

Title

Process of protein transport by the type III secretion system.

Journal

Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004

Reference

PMID:12360191

Authors

Cornelis GR

Title

The Yersinia Ysc-Yop 'type III' weaponry.

Journal

Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932

Reference

PMID:17215876

Authors

Baron C

Title

VirB8: a conserved type IV secretion system assembly factor and drug target.

Journal

Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148

Reference

PMID:17943123

Authors

Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S

Title

Helicobacter exploits integrin for type IV secretion and kinase activation.

Journal

Nature 449:862-6 (2007)
DOI:10.1038/nature06187

Reference

PMID:16092524

Authors

Christie PJ, Cascales E

Title

Structural and dynamic properties of bacterial type IV secretion systems (review).

Journal

Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316

Reference

PMID:15546668

Authors

Christie PJ

Title

Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.

Journal

Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013

Reference

PMID:15590781

Authors

Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D

Title

Type V protein secretion pathway: the autotransporter story.

Journal

Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004

Reference

PMID:9778731

Authors

Henderson IR, Navarro-Garcia F, Nataro JP

Title

The great escape: structure and function of the autotransporter proteins.

Journal

Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3

Reference

PMID:18524912

Authors

Filloux A, Hachani A, Bleves S

Title

The bacterial type VI secretion machine: yet another player for protein transport across membranes.

Journal

Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0

Reference

PMID:19251641

Authors

Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ

Title

Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.

Journal

Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106

Reference

PMID:17603507

Authors

Kulasekara HD, Miller SI

Title

Threonine phosphorylation times bacterial secretion.

Journal

Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734

Reference

PMID:18078384

Authors

Driessen AJ, Nouwen N

Title

Protein translocation across the bacterial cytoplasmic membrane.

Journal

Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747

Reference

PMID:14641032

Authors

Pool MR

Title

Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?

Journal

Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232

Reference

PMID:19299134

Authors

Desvaux M, Hebraud M, Talon R, Henderson IR

Title

Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.

Journal

Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004

Reference

PMID:15063851

Authors

Nakatogawa H, Murakami A, Ito K

Title

Control of SecA and SecM translation by protein secretion.

Journal

Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001

KO pathway

ko03070

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