KEGG   Leishmania donovani: LDBPK_060890
Entry
LDBPK_060890      CDS       T02289                                 
Name
(RefSeq) dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
ldo  Leishmania donovani
Pathway
ldo00240  Pyrimidine metabolism
ldo00670  One carbon pool by folate
ldo00790  Folate biosynthesis
ldo01100  Metabolic pathways
ldo01232  Nucleotide metabolism
ldo01240  Biosynthesis of cofactors
Module
ldo_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:ldo00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    LDBPK_060890
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    LDBPK_060890
   00670 One carbon pool by folate
    LDBPK_060890
Enzymes [BR:ldo01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     LDBPK_060890
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     LDBPK_060890
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1 Spo12
Other DBs
NCBI-GeneID: 13391751
NCBI-ProteinID: XP_003858395
UniProt: E9B8U9
LinkDB
Position
6:382839..384401
AA seq 520 aa
MSRAAARFKIPMPATKADFAFPSLRAFSIVVALDKQHGIGDGESIPWRVPEDMAFFKDQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGKR
AAAAQDVVVVNDGLAEALRLLARPPYCSSIETAYCVGGAQVYADAMLSPCVEKLQEVYLT
RIYTTAPACTRFFPFPPENTTTAWDLASSQGRRKSEADGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TNAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIRSIVETIKANPNDRRLLFTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVGALKSQLERVP
HAFPTLVFKEERQFLEDYELTDMEVIDYVPHPPIKMEMAV
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgtccagggcagctgcgaggtttaagattccgatgccggcgacgaaggcggacttcgcc
ttcccctctctgcgcgccttctccatcgttgtggccctcgataagcagcacggcatcggc
gacggcgagtcgatcccgtggcgggtgccggaggacatggcgttcttcaaggaccagacg
acgctgttgcgcaacaaaaagccgccgacggagaagaagcgcaacgctgtcgtgatgggc
cgcaagacgtgggagagcgtcccggtaaagttccgaccactcaagggacggctgaacatt
gtgttgtcctcgaaggccaccgtcgaggagcttctggcgccgctgccggagggaaagcgc
gctgccgcggcgcaggatgtggtggtggtgaacgacggtctggccgaggcgctccgcctc
ctcgcacgcccgccgtactgcagctccatcgagacagcgtattgcgtcgggggtgcgcag
gtttatgcggacgccatgctgtcgccgtgcgtcgagaagctgcaggaggtgtacctgacc
cgcatctacacgacggcgcctgcgtgtacgcgcttctttccgtttccgcccgagaacacc
accacggcgtgggacctggcgtcgtctcagggacgccgcaagagcgaggcggacggcctc
gagttcgagatctgcaagtacgtgccgcgtaaccatgaggagcggcagtaccttgagctg
attgaccgcatcatgaagacggggatcgtgaaggaggaccgcaccggcgtgggcaccatc
agcctcttcggcgcacagatgcgcttctccctacgcgacaaccgcctgccgctgctgacg
acgaagcgtgtcttctggcgcggcgtgtgcgaggagctgctgtggttcctgcgcggggag
acgaacgcgcagctgctggcggacaaggacattcacatctgggacggcaacggctcgcgc
gagtttctcgacagccgcggcttgacagagaataaggagatggacctcggccctgtctac
ggcttccagtggcgccacttcggggcagattacaaggggtttgaagcgaactacgacggc
gaaggggtggaccagatcaggtccatcgtggagacgatcaaggcgaacccgaacgaccgc
cgccttctattcactgcctggaacccgtgcgcgctgcaaaagatggcgctgccgccgtgc
cacttgcttgctcaattctacgtgaacacggacacgagcgagctatcctgcatgctgtac
cagcgctcgtgcgacatgggtctcggcgtccctttcaacatcgcctcctacgcgctgctc
accatcctcattgccaaggcgacgggcctgcggcccggtgagcttgtgcacacccttggt
gacgcccacgtctaccgcaaccacgtcggtgccctcaagtcgcagctcgagcgagtcccg
cacgcgttcccgaccctcgtcttcaaggaggagcgtcagttcctcgaggactacgagtta
acggacatggaggtgatcgactacgttccacacccgccgatcaagatggagatggccgta
tag

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