Leishmania panamensis: LPMP_060820
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Entry
LPMP_060820 CDS
T06539
Symbol
DHFR-TS
Name
(RefSeq) dihydrofolate reductase-thymidylate synthase
KO
K13998
dihydrofolate reductase / thymidylate synthase [EC:
1.5.1.3
2.1.1.45
]
Organism
lpan
Leishmania panamensis
Pathway
lpan00240
Pyrimidine metabolism
lpan00670
One carbon pool by folate
lpan00790
Folate biosynthesis
lpan01100
Metabolic pathways
lpan01232
Nucleotide metabolism
lpan01240
Biosynthesis of cofactors
Module
lpan_M00938
Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:
lpan00001
]
09100 Metabolism
09104 Nucleotide metabolism
00240 Pyrimidine metabolism
LPMP_060820 (DHFR-TS)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
LPMP_060820 (DHFR-TS)
00670 One carbon pool by folate
LPMP_060820 (DHFR-TS)
Enzymes [BR:
lpan01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
LPMP_060820 (DHFR-TS)
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.45 thymidylate synthase
LPMP_060820 (DHFR-TS)
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Gene cluster
GFIT
Motif
Pfam:
Thymidylat_synt
DHFR_1
Motif
Other DBs
NCBI-GeneID:
22572288
NCBI-ProteinID:
XP_010703963
UniProt:
A0A088S2I0
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Position
6:361483..363048
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AA seq
521 aa
AA seq
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MSRAAARFKIPMSVTKDCFAFPSLRCFSIIVAVDEQHGIGDGKTIPWQVPEDMAFFKDQT
TLLRNKKPPTEKKRNAVVMGRQTWESVPLKYRPLKGRLNVVLSSKATVDELLAPLPEGKR
AAAAQDLVVVNGGLAEALHLLARPPHCSSIETAYCVGGAQVYSDAMTAPCVEKLQEVYLT
RIYATAPECTRFYPFPPTNAAAAAWDLAWTQGRQRSETGGVEYEIRKYVPHNHEERQYLE
LIDRIMKTGIVKEDRTGVGILSLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRG
ETNAQLLADKDIHIWDGNGSREFLDSRGLTANKEMDLGPVYGFQWRHFGAQYKGFEANYD
GEGVDQIKSIVETIKVNPNDRRLLLTAWNPCALHEMALPPCHLLAQFYVNTDAKELSCML
YQRSCDMGLGVPFNIASYALLTILMAKATGLRPGELVHTLGDAHVYRNHIDALKVQLERT
PNAFPTLVFKREREFLEDYELSDMEVIDYAPYPPIKMEMAV
NT seq
1566 nt
NT seq
+upstream
nt +downstream
nt
atgtccagggcagctgcgaggtttaagatcccgatgtcggtgacgaaggactgctttgcc
ttcccctcccttcgctgcttctccatcattgtcgccgttgatgagcagcacggcatcggc
gacggaaagacaatcccgtggcaggtgccggaggacatggcgttcttcaaagaccaaacc
acgctgctacgcaacaagaaaccgccgacagagaagaagcgcaacgccgtcgtgatgggc
cgccagacgtgggaaagcgttccgctcaagtaccggccactcaagggtcggctgaacgtg
gtgctttcctcgaaggccaccgtggacgagcttctggcgccactgccggagggaaagcgg
gccgcagcggcgcaggatctggtggtggtgaacggcggactcgccgaggcgctccatctc
ctcgcacggccgccgcactgcagctccattgaaacagcgtactgcgtcggtggcgcgcag
gtttactccgacgccatgacggcgccgtgcgttgagaagctgcaggaagtgtacctgacc
cgcatctacgcgacggcgccggagtgtacgcgcttctacccgttcccgcccacgaacgcc
gccgccgccgcgtgggacctggcatggactcagggacgccagcggagcgagactggcggt
gtcgagtacgagatccgaaaatacgtgccacacaaccacgaggagcggcagtacctcgaa
ctgattgaccgcatcatgaagactggtattgtgaaggaggaccgcaccggagtgggcatt
ctcagcctcttcggcgcgcagatgcgcttctccttgcgagacaaccgcctgccgctgttg
acaacgaagcgcgttttctggcgcggcgtgtgcgaggagctgctgtggttcctgcgcggc
gaaacaaacgcccagttgctggcggacaaggacattcacatctgggatggtaacggctcg
cgcgagtttctcgacagccgcggcttgacggcgaataaggagatggatctcggtcctgtc
tacggattccagtggcgccacttcggagcacagtacaaggggtttgaggcgaattacgat
ggcgaaggggtggaccagatcaaatccatcgtggagaccatcaaggtgaacccaaacgac
cgccgcctcctgttaactgcctggaacccatgcgcgctgcacgagatggcgctgccgccc
tgtcacttgcttgctcagttctacgtgaacacggacgcgaaggagctgtcctgcatgctg
taccagcgctcgtgcgacatggggctcggcgtccccttcaacatcgcctcctacgcgctg
ctcaccatccttatggcaaaagccacgggtctgcggcctggggaactcgtgcacacgctc
ggcgacgcccatgtctaccgcaaccacatcgatgctctgaaagtgcagctcgagcgaacc
ccgaacgccttcccgaccctcgtgttcaagagggaacgggagttcctggaggactacgag
ttgtcagacatggaggtgatcgactacgcgccatacccgcctattaagatggagatggcc
gtatag
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