Entry Name Parkinson disease
Description Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class Human Diseases; Neurodegenerative diseaseBRITE hierarchy
Pathway map Disease Reference Authors Abou-Sleiman PM, Muqit MM, Wood NW
Title Expanding insights of mitochondrial dysfunction in Parkinson's disease.
Journal Reference Authors Lim KL, Lim TM
Title Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
Journal Reference Authors Bobela W, Aebischer P, Schneider BL
Title Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
Journal Reference Authors Eriksen JL, Wszolek Z, Petrucelli L
Title Molecular pathogenesis of Parkinson disease.
Journal Reference Authors Olanow CW, McNaught KS
Title Ubiquitin-proteasome system and Parkinson's disease.
Journal Reference Authors Lim KL, Tan JM
Title Role of the ubiquitin proteasome system in Parkinson's disease.
Journal Reference Authors Maiti P, Manna J, Dunbar GL
Title Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
Journal Reference Authors Dev KK, van der Putten H, Sommer B, Rovelli G
Title Part I: parkin-associated proteins and Parkinson's disease.
Journal Reference Authors Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G
Title Missing pieces in the Parkinson's disease puzzle.
Journal Reference Authors Cali T, Ottolini D, Brini M
Title Calcium signaling in Parkinson's disease.
Journal Reference Authors Bezprozvanny I
Title Calcium signaling and neurodegenerative diseases.
Journal Reference Authors Zaichick SV, McGrath KM, Caraveo G
Title The role of Ca(2+) signaling in Parkinson's disease.
Journal Reference Authors Ludtmann MHR, Abramov AY
Title Mitochondrial calcium imbalance in Parkinson's disease.
Journal Reference Authors Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
Title Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
Journal Reference Authors Mercado G, Valdes P, Hetz C
Title An ERcentric view of Parkinson's disease.
Journal Reference Authors Mercado G, Castillo V, Soto P, Sidhu A
Title ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
Journal Reference Authors Tsujii S, Ishisaka M, Hara H
Title Modulation of endoplasmic reticulum stress in Parkinson's disease.
Journal Reference Authors Shah A, Chao J, Legido-Quigley C, Chang RC
Title Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
Journal Reference Authors Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
Title Protective and toxic roles of dopamine in Parkinson's disease.
Journal Reference Authors Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
Title The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
Journal Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference Authors Perez RG, Hastings TG
Title Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
Journal Reference Authors Segura-Aguilar J
Title A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
Journal Reference Authors Bose A, Beal MF
Title Mitochondrial dysfunction in Parkinson's disease.
Journal Reference Authors Cieri D, Brini M, Cali T
Title Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
Journal Reference Authors Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
Title Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
Journal Reference Authors Cali T, Ottolini D, Brini M
Title Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
Journal Reference Authors Gaki GS, Papavassiliou AG
Title Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
Journal Reference Authors Franco-Iborra S, Vila M, Perier C
Title The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
Journal Reference Authors de Vries RL, Przedborski S
Title Mitophagy and Parkinson's disease: be eaten to stay healthy.
Journal Reference Authors Deas E, Wood NW, Plun-Favreau H
Title Mitophagy and Parkinson's disease: the PINK1-parkin link.
Journal Reference Authors Pickrell AM, Youle RJ
Title The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Journal Reference Authors Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
Title PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
Journal Reference Authors Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
Title Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
Journal Reference Authors Oh SE, Mouradian MM
Title Regulation of Signal Transduction by DJ-1.
Journal Reference Authors Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
Title Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
Journal Reference Authors Melo TQ, Copray SJCVM, Ferrari MFR
Title Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
Journal Reference Authors Zhai S, Shen W, Graves SM, Surmeier DJ
Title Dopaminergic modulation of striatal function and Parkinson's disease.
Journal Reference Authors Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
Title Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
Journal Related map04141 Protein processing in endoplasmic reticulum
KO pathway
