Entry Name Tuberculosis
Description Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Disease Reference Authors Saiga H, Shimada Y, Takeda K
Title Innate immune effectors in mycobacterial infection.
Journal Reference Authors Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
Title The immunology of tuberculosis: from bench to bedside.
Journal Reference Authors van Crevel R, Ottenhoff TH, van der Meer JW
Title Innate immunity to Mycobacterium tuberculosis.
Journal Reference Authors Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
Title Role of C-type lectins in mycobacterial infections.
Journal Reference Authors Jo EK, Yang CS, Choi CH, Harding CV
Title Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Journal Reference Authors Marakalala MJ, Graham LM, Brown GD
Title The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
Journal Reference Authors Koul A, Herget T, Klebl B, Ullrich A
Title Interplay between mycobacteria and host signalling pathways.
Journal Reference Authors Torrelles JB, Schlesinger LS
Title Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
Journal Reference Authors Briken V, Porcelli SA, Besra GS, Kremer L
Title Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Journal Reference Authors Baena A, Porcelli SA
Title Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
Journal Reference Authors Flannagan RS, Cosio G, Grinstein S
Title Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
Journal Reference Authors Pieters J
Title Mycobacterium tuberculosis and the macrophage: maintaining a balance.
Journal Reference Authors Scherr N, Jayachandran R, Mueller P, Pieters J
Title Interference of Mycobacterium tuberculosis with macrophage responses.
Journal Indian J Exp Biol 47:401-6 (2009)
Reference Authors Reith W, LeibundGut-Landmann S, Waldburger JM.
Title Regulation of MHC class II gene expression by the class II transactivator.
Journal Reference Authors Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
Title Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
Journal Reference Authors Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
Title Mycobacterium tuberculosis prevents inflammasome activation.
Journal Reference Authors Shtrichman R, Samuel CE
Title The role of gamma interferon in antimicrobial immunity.
Journal Related map00571 Lipoarabinomannan (LAM) biosynthesis
map04612 Antigen processing and presentation
map04620 Toll-like receptor signaling pathway
map04621 NOD-like receptor signaling pathway
KO pathway
