Entry Name Epstein-Barr virus infection
Description Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Disease H00367 Infectious mononucleosis
Reference Authors Young LS, Rickinson AB.
Title Epstein-Barr virus: 40 years on.
Journal Reference Authors Saha A, Robertson ES
Title Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal Reference Authors Ning S
Title Innate immune modulation in EBV infection.
Journal Reference Authors Stanfield BA, Luftig MA
Title Recent advances in understanding Epstein-Barr virus.
Journal Reference Authors van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal Reference Authors Rajsbaum R, Garcia-Sastre A
Title Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal Reference Authors Hoffmann HH, Schneider WM, Rice CM
Title Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal Reference Authors Spender LC, Inman GJ
Title Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal Reference Authors Fu Q, He C, Mao ZR
Title Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal Reference Authors Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal Reference Authors Melchjorsen J
Title Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal Reference Authors Hansen TH, Bouvier M
Title MHC class I antigen presentation: learning from viral evasion strategies.
Journal Reference Authors Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal Reference Authors Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal Reference Authors Ghosh Roy S, Robertson ES, Saha A
Title Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal Reference Authors Dawson CW, Port RJ, Young LS
Title The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal Reference Authors Cai Q, Chen K, Young KH
Title Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal Reference Authors Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal Cell Mol Immunol 4:185-96 (2007)
Reference Authors Ersing I, Bernhardt K, Gewurz BE
Title NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal Reference Authors Wang LW, Jiang S, Gewurz BE
Title Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal Reference Authors Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal Reference Authors Edwards RH, Marquitz AR, Raab-Traub N
Title Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal Reference Authors Thorley-Lawson DA
Title Epstein-Barr virus: exploiting the immune system.
Journal Reference Authors Eliopoulos AG, Young LS
Title LMP1 structure and signal transduction.
Journal Reference Authors Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal Reference Authors Kang H, Kiess A, Chung CH
Title Emerging biomarkers in head and neck cancer in the era of genomics.
Journal Reference Authors Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal Reference Authors Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal Reference Authors Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal Reference Authors Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal Reference Authors Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal Reference Authors Longnecker R
Title Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal Reference Authors El-Sharkawy A, Al Zaidan L, Malki A
Title Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal Reference Authors Dolcetti R, Masucci MG
Title Epstein-Barr virus: induction and control of cell transformation.
Journal Reference Authors Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal Related map04612 Antigen processing and presentation
map04620 Toll-like receptor signaling pathway
map04622 RIG-I-like receptor signaling pathway
map04662 B cell receptor signaling pathway
KO pathway
