Entry Name Epstein-Barr virus infection
Description Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map ko05169 Epstein-Barr virus infection
Disease H00367 Infectious mononucleosis
Orthology K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02084 APAF1; apoptotic protease-activating factor
K02159 BAX; apoptosis regulator BAX
K02161 BCL2; apoptosis regulator Bcl-2
K02373 FADD; FAS-associated death domain protein
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K03028 PSMD2, RPN1; 26S proteasome regulatory subunit N1
K03029 PSMD4, RPN10; 26S proteasome regulatory subunit N10
K03030 PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11
K03031 PSMD8, RPN12; 26S proteasome regulatory subunit N12
K03032 PSMD1, RPN2; 26S proteasome regulatory subunit N2
K03033 PSMD3, RPN3; 26S proteasome regulatory subunit N3
K03035 PSMD12, RPN5; 26S proteasome regulatory subunit N5
K03036 PSMD11, RPN6; 26S proteasome regulatory subunit N6
K03037 PSMD6, RPN7; 26S proteasome regulatory subunit N7
K03038 PSMD7, RPN8; 26S proteasome regulatory subunit N8
K03039 PSMD13, RPN9; 26S proteasome regulatory subunit N9
K03061 PSMC2, RPT1; 26S proteasome regulatory subunit T1
K03062 PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03063 PSMC4, RPT3; 26S proteasome regulatory subunit T3
K03064 PSMC6, RPT4; 26S proteasome regulatory subunit T4
K03065 PSMC3, RPT5; 26S proteasome regulatory subunit T5
K03066 PSMC5, RPT6; 26S proteasome regulatory subunit T6
K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03160 TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03174 TRAF3; TNF receptor-associated factor 3
K03875 SKP2, FBXL1; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K04012 CR2, CD21; complement receptor type 2
K04377 MYC; Myc proto-oncogene protein
K04390 TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04430 MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2 ]
K04431 MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2 ]
K04432 MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2 ]
K04433 MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 JUN; transcription factor AP-1
K04451 TP53, P53; tumor protein p53
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25 ]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04503 CCND1; G1/S-specific cyclin-D1
K04692 STAT3; signal transducer and activator of transcription 3
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04726 BID; BH3 interacting domain death agonist
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1 ]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05411 IRF3; interferon regulatory factor 3
K05653 ABCB2, TAP1; ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14 ]
K05654 ABCB3, TAP2; ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14 ]
K05718 ITGAL, CD11a; integrin alpha L
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11 ]
K05872 NFKBIE; NF-kappa-B inhibitor epsilon
K06053 RBPSUH, RBPJK; recombining binding protein suppressor of hairless
K06054 HES1; hairy and enhancer of split 1
K06063 SNW1, SKIIP, SKIP; SNW domain-containing protein 1
K06065 NCOR2, SMRT; nuclear receptor co-repressor 2
K06066 CIR; CBF1 interacting corepressor
K06450 CD3D; T-cell surface glycoprotein CD3 delta chain
K06451 CD3E; T-cell surface glycoprotein CD3 epsilon chain
K06452 CD3G; T-cell surface glycoprotein CD3 gamma chain
K06453 CD3Z, CD247; CD3Z antigen, zeta polypeptide
K06465 CD19; B-lymphocyte antigen CD19
K06468 FCER2, CD23; low affinity immunoglobulin epsilon Fc receptor
K06490 ICAM1, CD54; intercellular adhesion molecule 1
K06492 CD58, LFA3; CD58 antigen
K06618 RB1; retinoblastoma-associated protein
K06620 E2F3; transcription factor E2F3
K06624 CDKN1B, P27, KIP1; cyclin-dependent kinase inhibitor 1B
K06625 CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
K06626 CCNE; G1/S-specific cyclin-E1
K06691 RPN13; 26S proteasome regulatory subunit N13
K06751 MHC1; MHC class I antigen
K06752 MHC2; MHC class II antigen
K06856 IGH; immunoglobulin heavy chain
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K07371 BLNK; B-cell linker protein
K08055 B2M; beta-2-microglobulin
K08058 TAPBP; TAP binding protein (tapasin)
K09253 RELB; transcription factor RelB
K09279 RUNX3, AML2; runt-related transcription factor 3
K09389 E2F2; transcription factor E2F2
K09447 IRF7; interferon regulatory factor 7
K09849 TRAF5; TNF receptor-associated factor 5
K10140 DDB2; DNA damage-binding protein 2
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K10159 TLR2, CD282; toll-like receptor 2
K10784 TRAV; T cell receptor alpha chain V region
K10785 TRBV; T-cell receptor beta chain V region
K10881 SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11644 SIN3A; paired amphipathic helix protein Sin3a
K11859 TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12 ]
K12159 ISG15; ubiquitin cross-reactive protein
K12646 RIGI, DDX58; ATP-dependent RNA helicase DDX58 [EC:5.6.2.6 ]
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K12671 CXCL10, IP10; C-X-C motif chemokine 10
K14021 BAK, BAK1; Bcl-2 homologous antagonist/killer
K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1 ]
K16341 BCL2L11, BIM; Bcl-2-like protein 11
K17454 E2F1; transcription factor E2F1
K19202 SAP30; histone deacetylase complex subunit SAP30
K19450 BLLF1; Lymphocryptovirus envelope glycoprotein GP350
K19451 gH; Lymphocryptovirus envelope glycoprotein H
K19452 gL; Lymphocryptovirus envelope glycoprotein L
K19453 BBRF2; Lymphocryptovirus virion egress protein UL7
K19455 BGLF4; Lymphocryptovirus serine/threonine-protein kinase BGLF4 [EC:2.7.11.1 ]
K19456 EBNALP; Lymphocryptovirus nuclear antigen leader protein
K19457 EBNA2; Lymphocryptovirus nuclear antigen 2
K19458 EBNA6, EBNA3C; Lymphocryptovirus nuclear antigen 6
K19459 LMP1; Lymphocryptovirus latent membrane protein 1
K19460 LMP2A; Lymphocryptovirus latent membrane protein 2A
K19461 EBNA1, BKRF1; Lymphocryptovirus nuclear antigen 1
K19462 BZLF1; Lymphocryptovirus trans-activator protein BZLF1
K19463 BHRF1; Lymphocryptovirus apoptosis regulator BHRF1
K21855 EBNA3, EBNA3A; Lymphocryptovirus nuclear antigen 3
K21856 EBNA4, EBNA3B; Lymphocryptovirus nuclear antigen 4
K22972 BPLF1; Lymphocryptovirus large tegment protein deneddylase
K22973 BARF1; Lymphocryptovirus secreted protein BARF1
K22974 BNLF2A; Lymphocryptovirus protein BNLF2a
K22975 BILF1; Lymphocryptovirus G-protein coupled receptor BILF1
K23074 LMP2B; Lymphocryptovirus latent membrane protein 2B
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Young LS, Rickinson AB.
Title Epstein-Barr virus: 40 years on.
Journal Reference Authors Saha A, Robertson ES
Title Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal Reference Authors Ning S
Title Innate immune modulation in EBV infection.
Journal Reference Authors Stanfield BA, Luftig MA
Title Recent advances in understanding Epstein-Barr virus.
Journal Reference Authors van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal Reference Authors Rajsbaum R, Garcia-Sastre A
Title Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal Reference Authors Hoffmann HH, Schneider WM, Rice CM
Title Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal Reference Authors Spender LC, Inman GJ
Title Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal Reference Authors Fu Q, He C, Mao ZR
Title Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal Reference Authors Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal Reference Authors Melchjorsen J
Title Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal Reference Authors Hansen TH, Bouvier M
Title MHC class I antigen presentation: learning from viral evasion strategies.
Journal Reference Authors Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal Reference Authors Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal Reference Authors Ghosh Roy S, Robertson ES, Saha A
Title Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal Reference Authors Dawson CW, Port RJ, Young LS
Title The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal Reference Authors Cai Q, Chen K, Young KH
Title Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal Reference Authors Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal Cell Mol Immunol 4:185-96 (2007)
Reference Authors Ersing I, Bernhardt K, Gewurz BE
Title NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal Reference Authors Wang LW, Jiang S, Gewurz BE
Title Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal Reference Authors Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal Reference Authors Edwards RH, Marquitz AR, Raab-Traub N
Title Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal Reference Authors Thorley-Lawson DA
Title Epstein-Barr virus: exploiting the immune system.
Journal Reference Authors Eliopoulos AG, Young LS
Title LMP1 structure and signal transduction.
Journal Reference Authors Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal Reference Authors Kang H, Kiess A, Chung CH
Title Emerging biomarkers in head and neck cancer in the era of genomics.
Journal Reference Authors Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal Reference Authors Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal Reference Authors Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal Reference Authors Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal Reference Authors Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal Reference Authors Longnecker R
Title Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal Reference Authors El-Sharkawy A, Al Zaidan L, Malki A
Title Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal Reference Authors Dolcetti R, Masucci MG
Title Epstein-Barr virus: induction and control of cell transformation.
Journal Reference Authors Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal Related ko04064 NF-kappa B signaling pathway
ko04612 Antigen processing and presentation
ko04620 Toll-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04662 B cell receptor signaling pathway
