KEGG   Mus caroli (Ryukyu mouse): 110291292
Entry
110291292         CDS       T05910                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6 isoform X2
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mcal  Mus caroli (Ryukyu mouse)
Pathway
mcal00140  Steroid hormone biosynthesis
mcal01100  Metabolic pathways
mcal04913  Ovarian steroidogenesis
mcal04925  Aldosterone synthesis and secretion
mcal04927  Cortisol synthesis and secretion
mcal04934  Cushing syndrome
Module
mcal_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mcal_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mcal_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mcal_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mcal00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    110291292
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    110291292
   04925 Aldosterone synthesis and secretion
    110291292
   04927 Cortisol synthesis and secretion
    110291292
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110291292
Enzymes [BR:mcal01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     110291292
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     110291292
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR
Other DBs
NCBI-GeneID: 110291292
NCBI-ProteinID: XP_021014011
UniProt: A0A6P5PGH7
LinkDB
Position
3:complement(92988687..93002196)
AA seq 375 aa
MPGWGYLETGAGGFLGQRIIKILMQENELQEVKALDKVFRSETKKKFSKLQTKAKVTVLE
GDILDAQCLRRACQGIGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLXACIQASVP
AFIFSSSVDVAGPNSYKDIVLNGHEDEHRESAWSDPYPYSKKMAEKAVLAANGSMLKNGG
TLHTCALRPMYIYGERSRFISNTIITALKNKNILGCTGKFSTANPVYVGNVAWAHILAAR
GLRDPKKSPNIQGEFYYISDDTPHQSYDDLSYTLSKEWGFCLDSNWSLPVPLLYWLAFLL
ETVSFLLSPIYRYIPPFNRHLVTLSNSTFTFSYKKAQRDLGYEPLVSWEKAKQKTSEWIG
TLVMKHRETLDTKSQ
NT seq 1128 nt   +upstreamnt  +downstreamnt
atgcctggatggggctacctggaaacaggagcaggaggattcctgggccagaggatcatc
aagatattgatgcaagagaacgaactgcaggaggtaaaagctctggacaaagtcttcagg
tcagaaaccaaaaagaaattctccaagctgcagacaaaggccaaggtgacagtgttggaa
ggagacattctggatgcccagtgcctgaggagagcctgccagggcatcggcatctctgtt
gtcatccacactgctgctgtcattgatgtcacaggtgtcattcccaggcagaccatccta
gatgtcaatctgaaaggtacccagaacttattggangcctgtatccaagccagtgtgcca
gccttcatcttttccagctcagttgatgttgcagggcccaactcgtacaaagacattgtc
ctgaatggccacgaggatgagcatcgtgaaagtgcatggtctgacccatacccatacagc
aaaaagatggctgagaaggcagtgctggcagccaatgggagcatgctgaaaaatggtggc
actttgcatacttgtgcattaaggcccatgtacatttatggagagagaagtcgattcatt
tctaacacaataattacagccctcaaaaataagaatattctgggttgtacaggcaaattc
tctacagccaacccagtatatgtgggtaatgtggcctgggcacacattctggctgccagg
ggccttcgagaccccaagaagtcaccaaatatccaaggagagttctactacatctcagat
gacacccctcaccaaagctatgatgatttaagttacaccctgagcaaggagtggggcttc
tgccttgattccaactggagccttcctgtgcccttactgtactggcttgccttcctgctg
gaaactgtgagcttcctgctgagtccaatctacaggtatatacctccctttaaccgccac
ttggtcacactgtcaaatagcacattcactttctcctacaagaaagctcagcgagatctg
ggctatgagccactagtcagctgggagaaagccaaacagaaaacctcagagtggatcggg
acactagtgatgaagcacagggagaccctggacacaaagtctcagtga

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