Mus caroli (Ryukyu mouse): 110292727 Help Entry 110292727         CDS       T05910                                  Symbol Irs1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism mcal  Mus caroli (Ryukyu mouse) Pathway mcal04022   cGMP-PKG signaling pathway mcal04068   FoxO signaling pathway mcal04081   Hormone signaling mcal04140   Autophagy - animal mcal04150   mTOR signaling pathway mcal04151   PI3K-Akt signaling pathway mcal04152   AMPK signaling pathway mcal04211   Longevity regulating pathway mcal04213   Longevity regulating pathway - multiple species mcal04722   Neurotrophin signaling pathway mcal04910   Insulin signaling pathway mcal04920   Adipocytokine signaling pathway mcal04923   Regulation of lipolysis in adipocytes mcal04930   Type II diabetes mellitus mcal04931   Insulin resistance mcal04932   Non-alcoholic fatty liver disease mcal04935   Growth hormone synthesis, secretion and action mcal04960   Aldosterone-regulated sodium reabsorption mcal05010   Alzheimer disease mcal05206   MicroRNAs in cancer mcal05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mcal00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     110292727 (Irs1)    04022 cGMP-PKG signaling pathway     110292727 (Irs1)    04151 PI3K-Akt signaling pathway     110292727 (Irs1)    04152 AMPK signaling pathway     110292727 (Irs1)    04150 mTOR signaling pathway     110292727 (Irs1)   09133 Signaling molecules and interaction    04081 Hormone signaling     110292727 (Irs1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     110292727 (Irs1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     110292727 (Irs1)    04923 Regulation of lipolysis in adipocytes     110292727 (Irs1)    04920 Adipocytokine signaling pathway     110292727 (Irs1)    04935 Growth hormone synthesis, secretion and action     110292727 (Irs1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     110292727 (Irs1)   09156 Nervous system    04722 Neurotrophin signaling pathway     110292727 (Irs1)   09149 Aging    04211 Longevity regulating pathway     110292727 (Irs1)    04213 Longevity regulating pathway - multiple species     110292727 (Irs1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     110292727 (Irs1)   09164 Neurodegenerative disease    05010 Alzheimer disease     110292727 (Irs1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     110292727 (Irs1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     110292727 (Irs1)    04932 Non-alcoholic fatty liver disease     110292727 (Irs1)    04931 Insulin resistance     110292727 (Irs1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  110292727 NCBI-ProteinID:  XP_021015916 Ensembl:  MGP_CAROLIEiJ_G0014324 UniProt:  A0A6P5PKI9 LinkDB All DBs Position 1:complement(75425023..75484675) Genome browser AA seq 1230 aa AA seqDB search MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH HDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRL CLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVV AQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRT ESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRL HPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGF ISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYIL SRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSV ASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTS NLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMM MSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKL LPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGAR HQHLRLSSSSGRLRYTTTAEDSSSSTSSDSLGGGYCGARPESNLTHPHHHVLQPHLPRKV DTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQ PGYLAGPATSRSSPSVRCPPPLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIG PAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASL PRPTGAAPPPSSTASSSVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAK VIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGSEDVKRHSSASFENV WLRPGDVGGVSKESAPVCGAAGGLEKSLNYIDLDLAKERSQDCPSQQQSLPPPPPHQPLG SNEGNSPRRSSEDLSNYASISFQKQPEDHQ NT seq 3693 nt NT seq  +upstreamnt  +downstreamnt atggcaagccctccggataccgatggcttctcagacgtgcgcaaggtgggctacctgcgc aaacccaagagtatgcataagcgctttttcgtgctgcgggcggccagcgaggccgggggc ccagcgcgcctggagtattatgagaatgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggctgactccaagaac aagcatctggtggctctctacacccgagacgaacactttgccattgcggcggatagcgag gctgagcaagacagctggtaccaggctcttctgcagctgcataatcgggcaaaggcccac catgacggggctggaggaggctgcggtggtagctgcagcggcagctctggcgttggagag gcaggagaggacttgagctatgacacgggtccaggacccgcgttcaaggaggtctggcag gttatcctgaaacccaagggcctgggtcagacaaagaacctgattggcatctaccgcctc tgcctgaccagcaagaccatcagctttgtgaagctgaactccgaggcagccgctgtggtg ctgcagctgatgaacatcagacgctgtggccactcagagaacttcttcttcatcgaggtg gggcgttccgctgtgacagggcctggcgaattctggatgcaagtggatgactccgtggtg gcccagaacatgcatgagaccattctagaggccatgcgggccatgagcgatgagtttcgc cctcgcagcaaaagccagtcttcatccagttgctccaatcccatcagcgttcccctgcgc aggcaccatctcaacaaccctccacccagccaggtgggactgactcggagatctcgaact gagagcatcactgccacctcccctgccagtatggtgggtgggaaaccaggttccttccgg gtgcgtgcctccagcgatggcgaaggcaccatgtcccgtccagcatcagtggatggcagt cctgtgagccctagcaccaacaggacccacgcccatcggcatcgaggcagctccaggctg caccccccactcaaccacagccgctccatccccatgccttcttcgcgatgctcaccttca gccaccagcccagtgagtctgtcatctagtagtaccagtggccatggctccacttcagac tgtctcttcccaaggcgctctagtgcttccgtgtccggttcgcctagcgatggcggtttc atctcttctgatgagtatggttctagtccctgcgatttccgaagttccttccgcagtgtc accccagattccctggggcacaccccaccagccaggggtgaggaggagctgagcaattat atctgcatgggtggcaagggagcctccaccttggctgctcccaatggccactacattttg tccaggggtggcaacggccatcgctacatcccaggtgctaacttggggacaagcccagcg ctgcctggagatgaagccgcgggtgcagcagatctggataaccggtttcgaaagagaact cactccgcaggcacatctcctaccatttcccatcagaagaccccctcacagtcttcagtg gcttctattgaggaatatacagagatgatgcccgctgcctacccaccaggaggtggcagt ggaggccgactgcccggctaccggcattccgccttcgtgcccacccactcctatcccgaa gagggtctagagatgcaccacttggaacgtcgtggaggccaccaccgtccagacacctcc aacctccacactgatgatggctacatgcccatgtctcctggggtggctccagtgcccagc aaccgcaaaggaaatggggactatatgcccatgagccccaagagtgtatctgccccacag cagatcattaaccccatcagacgccacccacagagagtggaccccaatggctacatgatg atgtcacccagtggtagttgctcccctgacattggaggtgggtccagcagcagtagcagc atcagtgcagccccttctgggagcagctatgggaagccatggacaaatggagtagggggg caccatactcatgcccttcctcatgccaaacctcctgttgagagtggtggcggtaagctc ttgccttgcacaggtgactacatgaacatgtccccagtgggagattccaacaccagcagc ccctcagaatgctactatggcccagaagatccccagcacaagccggtcctctcttactac tcattgccaaggtcctttaagcacacccagcgccctggagagccagaggagggtgccagg caccagcatcttcgtctctcttctagctctggacgccttcgctataccacaactgccgaa gattcctcctcttctaccagcagcgacagtctgggtgggggttactgtggggctaggcca gagtctaacctcacacatccccaccaccatgtcttgcagccccacctgcctcgaaaggta gacacagctgcacagaccaacagccgcctggctcgacccacaaggctgtccttgggggat cccaaggcaagcaccttaccccgggttcgagagcagcaacagcagcaacagtcttccctg caccctcccgagcccaaaagcccaggagaatatgtgaatattgaattcgggagcggccag cctggctatttagctggccctgcaacttcccgtagctctccttcagttcgatgtccaccc ccgctccacccagctcctagagaagagactggctcggaagagtacatgaacatggacttg gggccaggccggagggcaacctggcaggagagtggtggagttgagttgggcagaataggc cctgcacctccagggtctgctacggtttgcaggccaacccgttcggtgccaaatagccgt ggtgactacatgaccatgcagataggttgtcctcgtcaaagctatgtggatacctctcca gtggccccagtcagctatgctgacatgcggacaggcattgctgcagagaaggcgagcctg cctagacccacaggagctgctcctcctccatcctccacagcctcttcttctgttacacct caaggagccaccgctgagcaagctactcactcttccttgctgggaggccctcagggacct gggggcatgagtgcattcaccagggtgaacctcagtcccaaccataaccagagtgccaaa gtgattcgcgcagacactcaagggtgccggaggaggcatagctctgagaccttctcagca cctactcgggctggcaatacggtgccctttggagcaggggctgcagtagggggcagcggt ggtggtggtggcggcagtgaggatgtaaaacgccacagctctgcatcctttgagaatgtg tggctgagacctggggatgtagggggagtctccaaggagtcggctccagtgtgtggggct gctgggggtttggagaagagtcttaactacatagacctggatttggccaaggagcgctct caggactgcccctctcaacagcagtccctaccaccccctccccctcaccagcccttaggc agcaatgagggcaactccccaagacgctccagtgaggatttaagcaactatgccagcatc agcttccagaagcagccagaggatcatcaatag

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