Mus caroli (Ryukyu mouse): 110299024 Help Entry 110299024         CDS       T05910                                  Symbol Ryr1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism mcal  Mus caroli (Ryukyu mouse) Pathway mcal04020   Calcium signaling pathway mcal04371   Apelin signaling pathway mcal04713   Circadian entrainment mcal04730   Long-term depression mcal04921   Oxytocin signaling pathway mcal05017   Spinocerebellar ataxia mcal05020   Prion disease mcal05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mcal00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     110299024 (Ryr1)    04020 Calcium signaling pathway     110299024 (Ryr1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     110299024 (Ryr1)   09156 Nervous system    04730 Long-term depression     110299024 (Ryr1)   09159 Environmental adaptation    04713 Circadian entrainment     110299024 (Ryr1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     110299024 (Ryr1)    05020 Prion disease     110299024 (Ryr1)    05022 Pathways of neurodegeneration - multiple diseases     110299024 (Ryr1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:mcal01009]     110299024 (Ryr1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mcal04147]     110299024 (Ryr1)    04040 Ion channels [BR:mcal04040]     110299024 (Ryr1) Protein phosphatases and associated proteins [BR:mcal01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      110299024 (Ryr1) Exosome [BR:mcal04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    110299024 (Ryr1) Ion channels [BR:mcal04040]  Voltage-gated cation channels   Ryanodine receptor    110299024 (Ryr1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Serglycin Motif Other DBs NCBI-GeneID:  110299024 NCBI-ProteinID:  XP_021024263 Ensembl:  MGP_CAROLIEiJ_G0029471 UniProt:  A0A6P5Q664 LinkDB All DBs Position 7:complement(28221536..28348572) Genome browser AA seq 5030 aa AA seqDB search MGDGGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVP PDLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLS CLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERY LHLSTASGELQVDASFMQTLWNMNPICSGCEEGFVTGGHVLCLFHGHMDECLTISPSDSD DQRRLVYYEGGPVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLGLTEDQGL VVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTY AAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLD SFSGKPRGSGPPAGSALPIEGVILSLQDLIGYFEPPSEELQHEEKQTKLRSLRNRQSLFQ EEGMLTLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCAL FSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKV LDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQY GKWYFEVMVDEVAPFLTAQATHLRVGWALSEGYSPYPGGGEGWGGNGVGDDLYSYGFDGL HLWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFP VVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLQPIKEYRREGPRGPHL VGPSRCLSHLDFVPCPVDTIQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDD NKRLHPCLVNFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTY MMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNP RLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVDSQSRGDRARIFRAEK SYAVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADDLAYVFNGHRGQRWHLGSEPF GRPWQSGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFRDIEIGDGFLPVCSLGPGQV GHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEPVPLEHPHYEVAR MDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLASPGLQPPA EDEARAAEPDTDYENLRRSAGGWGEAEGGKDGTAKEGTPGGTAQAGVEAQPARAENEKDA TTEKNKKRGFLFKAKKVAMMTQPPSTPALPRLPRDVVPADNRDDPEIILNTTTYYYSVRV FAGQEPSCVWVGWVTPDYHQHDMSFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGD FVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQ NVVQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLHVDTRR AGERLGWAVQCQEPLMMMALHIPEENRCMDILELSERLDLQRFHSHTLSLYRSVCALGNN RVAHALCSHVDQAQLLHALEDARLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLT PETRAITLFPPGRSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCFVVALPAAGATEAPARL SPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGVFSDED VKQILKMIEPEVFREEEEAEEEGEEEEEDEEEKEEDEEEEAHEKEDEEKEEAEDAAEEEK EELEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAECYVDKMQGNQRGRYGL LMKAFTMSAAETARRTREFRSPPQEQINMLLHFKNGADEEECPLPEEIRQDLVNFHQDLL AHCGIQLEGEEEEPEEESTLGSRLMSLLEKVKLVKKTEEKPEEEAAPEEHKPQSLQELVS HTVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISLSSVEDTMSLLECL GQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGE SKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAAS VIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAV FVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRR DRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPETHLIQAGKGEALRIRAILRS LVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLL HVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMV DSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKM PLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDQELYRIA MPCLCAIAGALPPDYVDASYSSKTEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFA EYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAW EWTVEKAREGEEEKTEKKKTRKISQTAQTYDPREGYNPQPPDLSVVTLSRELQAMAEQLA ENYHNTWGRKKKQELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTR GLKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFA KILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGT DAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTR NPYVEKLRPALGECLARLAAAMPVAFLEPELNEYNACSVYTTKSPRERAILGLPNSVEEM CPDIPVLERLMAEIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAG APPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHFI PTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNN RAHWLTEPNPNAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMA KSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIVLAKARYALKD TDEEVREFLQNNLNLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVSAVLY HLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKASWILT EDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMA YADIMAKSCHLEEGGENGEEGGEEEEVEVSFEEKEMEKQRLLYQQSRLHNRGAAEMVLQM ISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVL DLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNY LRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVF NSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKD MVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVT DPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFN VAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNR AQWEMPQVKESKRQFIFDVVNEGGESEKMEMFVSFCEDTIFEMQIAAQISEPEGEPEEDE DEGAEEAEEGAAGSDGSGSAAAAGVWVWLAASAGRTLRGLSYRSLRRRVRRLRRLTAREA ATAVAALLWALVTRAGGAGAGAAAGALRLLWGSLFGGGLVDSAKKVTVTELLAGMPDPTG DEVHGQQPSGAGSDAEGEGEGEGEGDAADGAGDEEAAADQAGTGGADGAVAVADGSPFRP EGAGGLGDMGDTTPVEPPTPEGSPILKRKLGVDGEEEEPPPEPEPEPEPEPEKADTENGE KEVPEPPPEPPKKTPPPPPPKKEGAGGAGLEELWGELEVQRVKFLNYLSRNFYTLRFLAL FLAFAINFILLFYKVSDSPPGEDDIEGSGAGDMSGAGSGDGSGWGSRAGEEVEGDEDENM VYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLY ITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLAS LEITAHNERKPDPPPGLLTWIMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNF FFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSE DEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVI LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLAN YMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 15093 nt NT seq  +upstreamnt  +downstreamnt atgggtgatggaggaggtgaaggcgaggacgaggtccagtttttgcggacggatgatgaa gtggtcctgcagtgcagcgccacggtgctcaaggaacagctgaagttgtgtctggccgct gaggggttcggcaaccgcctttgctttctggaacccaccagcaatgcgcagaatgtaccc cctgatctggccatctgctgcttcatcctggagcagtctctgtcagttcgagccctgcag gagatgctggccaatactgtggaggccggtgtggagtcatcccagggcgggggacacagg acactcttgtatgggcacgccatcctgctccggcacgcacacagccgtatgtacctgagt tgcctcaccacctcccgatccatgactgacaagttggcctttgacgtgggattacaggaa gatgcaacaggggaggcctgttggtggacgatgcacccagcctcaaagcagaggtctgaa ggagagaaggttcgagttggggatgaccttatccttgtgagtgtctcctccgagcgatac ctgcacctgtcaaccgcaagtggggagctccaggttgacgcctcctttatgcagacgctc tggaacatgaatcccatctgctctggctgtgaagagggctttgtgactggaggccatgtc ctgtgcctctttcatggacatatggatgaatgtctgaccatttccccttctgacagtgat gatcaacgcagacttgtctactacgagggagggcccgtgtgcactcatgcccgctcccta tggaggctagagccgctgagaatcagctggagtggaagccatctccgctggggccagcca ctaagaatcagacatgtgaccacagggaggtaccttgggctcactgaggaccaaggcctt gtggtggttgatgccagcaaggcccacaccaaggccacttccttttgcttccgaatctcc aaggagaagctggatgtggcccccaagagagatgtggagggcatgggtccccctgagatc aagtatggagagtcgctctgctttgtacagcatgtggcctcaggcctgtggctcacctat gctgccccagaccctaaggccctgaggcttggggtactcaagaagaaggccatgctgcac caggaaggccacatggatgatgcgttgtcactgacgcgatgccagcaggaggagtcccag gctgcccggatgatatacagcactgccggcctgtacaaccagttcataaagggtctcgat agcttcagcgggaagccacggggctcggggccaccggctgggtcagcactgcccatcgag ggcgtcatcctgagcctacaggacctcatcggctacttcgagccgccttcggaggagctg cagcacgaggagaagcagaccaagctgcgcagcctgcgcaaccgacagagcctcttccag gaggaggggatgctcaccctggtcctgaattgcattgaccgcctcaacgtctacaccacc gctgcccactttgccgagtttgcaggggaggaggcagctgagtcttggaaagagattgtg aacctgctctatgaacttctagcctctctgatccgtggcaatcgcaccaactgtgcgctc ttctccacaaacttggattggctggtcagcaagctggatcgtctggaggcctcatctggc atcctggaggtgttgtactgtgtcctgattgagagtcctgaggtactgaacatcatccag gagaaccacatcaagtctatcatctccctcttagacaagcatgggcggaatcacaaggtc ctggatgtgctgtgctcactctgtgtgtgcaatggtgtggctgtccgctccaaccaggac ctcatcaccgagaacttgctcccgggccgagaacttctgctgcagacaaacctcatcaac tatgtcaccagcatccgtcccaacatctttgtgggccgagcagagggctccacgcagtat ggcaaatggtactttgaggtgatggtggatgaggtggctccatttctgacagctcaggcc acccacctgagggtgggctgggccctcagcgagggctacagcccctaccccggaggcggc gagggctggggcggcaatggggtcggcgatgacctctattcttacggctttgatgggctg catctttggacagggcatgtggcacgcccagtgacttctccgggacaacacctcttggcc ccggaggatgtggtcagctgctgcctggacctcagcgtcccatccatctcctttcgtatc aatggctgccctgtgcagggtgtctttgaatccttcaacctcgatgggctcttcttccct gtcgtgagcttctcggctggtatcaaagtgcgctttctccttggtggccgccatggtgaa tttaagttcttgcccccacctggctatgctccatgccatgaagctgtgctccctcgggag cgactccatctccaacccatcaaagagtatcgcagggaggggcctcggggaccccacctg gtgggccccagtcgctgcctctcacatctggactttgtaccttgtcctgtggacaccatc cagatcgtcttgcccccccacctggagcggattcgggagaagctggcagagaacattcat gaactctgggcactgactcgcattgagcaaggatggacctatggtccggttcgggatgac aacaagaggctgcacccatgtcttgtgaatttccacagcttgccagaacctgagcggaat tacaacttgcagatgtcaggggagacactcaagactctgttggccctgggctgccatgtg ggcatggccgatgagaaggcagaagacaacctgaagaagacgaagctccctaagacgtat atgatgagcaatggatacaagccggctcctctggacctgagccacgtgaggctgacgcct gcacagacaactctggtggaccggctggcagagaacgggcacaatgtctgggcgagagac cgcgtggcacagggctggagctacagtgctgtgcaggacattcctgcacgcagaaatcct cgcctcgtgccctaccgcctgctggacgaggccaccaaacgcagcaatagggacagcctc tgccaggctgtgcgcaccctgctgggctatggctacaacatcgagcctcctgaccaggag cccagtcaggtggacagccagtctcgtggtgaccgggcccgcatcttccgggcagagaag tcctatgcagtccagagtggccgatggtactttgagttcgaagcagtcaccacaggagag atgcgagtgggctgggcaaggcctgaactgagacctgatgtggagctgggagcagacgat ttggcctatgtcttcaatgggcaccgaggccagcgctggcacttgggcagtgagccattt gggcgcccctggcagtcgggcgatgtcgtcggctgcatgattgatctcacagagaacacc atcatcttcaccctcaatggcgaggtcctcatgtctgactcgggctcggaaacagccttc cgtgacattgagatcggggacggcttcctgccagtctgcagcttgggacctggtcaggtg ggccacctgaacctgggccaggatgtgagctccctgaggttttttgccatctgtggcctc caggaaggttttgagccgttcgccatcaacatgcaacgcccagttaccacctggtttagc aagagtcttcctcagtttgagcctgtgccccttgaacacccccactatgaggtggcccgc atggatggcactgtggatacacccccctgcctgcgcttgacccaccgcacctggggttca cagaacagtctggtggagatgctgtttctccggctaagccttccggtccagttccaccag cacttccgctgcaccgcaggggccacacccctggcatcccctggcctgcagccacctgct gaagatgaggcccgggcagcagaaccagatacggactatgaaaacctgcgccgctccgct ggaggctggggagaggctgaggggggcaaggatggaactgccaaggaggggacacccgga ggcactgcccaggctggggtagaggctcagcctgcgagggcggagaatgagaaagacgct accaccgagaagaacaagaagagagggttcttgttcaaggccaagaaggttgccatgatg acccaaccaccttctactccggctcttccccgactccctcgagatgtggtacctgctgac aaccgcgacgaccctgagatcatcctcaacaccaccacgtactattactctgtgagggtc ttcgcgggtcaggagcccagctgcgtgtgggtgggctgggtcactcctgactaccatcaa catgacatgagcttcgacctcagcaaagtcagggcggtgacagtgaccatgggagatgaa caaggcaatgtccacagcagcctcaagtgtagcaactgctacatggtgtggggcggagat tttgtgagtcccggacagcagggccggatcagccacacggaccttgtcattggctgcctg gtggatctggccaccggcttgatgaccttcacagccaatggcaaagaaagcaacaccttc ttccaggtggaacccaacacgaagctgtttcctgctgtctttgtgctgcctacccaccag aacgtggtccagtttgagctggggaagcagaagaacatcatgccgctgtcagccgccatg ttcctgagcgagcgcaagaacccagccccacagtgcccaccaaggctggaggtgcagatg ctgatgcccgtctcctggagccgaatgcccaaccacttcctacatgtggacacgcggcgt gctggagagcggctgggctgggcagttcagtgccaggagccgctgatgatgatggcgcta cacatcccggaggagaacaggtgcatggacatcctggagctatctgagcggctggaccta cagcgcttccactcgcacacgctctcgctctaccgctcggtatgtgccctgggcaacaac cgcgtggctcatgccctgtgcagccacgtggaccaggcacagctgttgcatgcgctggag gatgcgcgcttgccaggtcctctgcgagcaggctactacgacctcctcatcagcatccac ctcgaaagtgcctgccgcagccgtcgctccatgctctctgagtacatcgtgccgctcacg ccggagacccgcgccatcacgcttttcccacccgggcgaagtgcggaagatggcccccgc cgccatggcctgcctggcgttggggtcacaacctccctgagacctccacaccatttctcc cccccgtgttttgtggtcgccctgccagctgctggggccacagaagctccagctcgcctc agccctgccatccctctggaggctctgcgagacaaggcgctgagaatgttgggggaagcc gtgcgtgatggaggacagcatgctcgcgacccggttgggggctctgtggagttccagttc gtcccggtgctcaagcttgtgtctaccctcctggtgatgggtgtctttagtgacgaggat gtgaagcagatcctgaagatgattgagcctgaagtcttcagggaggaagaagaggcggag gaggagggagaggaggaagaggaagatgaggaggagaaagaggaggatgaagaagaggag gcacacgagaaggaagatgaggaaaaagaagaggcagaggatgccgcagaagaggagaag gaggagcttgaggaggggctgctgcagatgaagctgcccgagtctgtgaaattacagatg tgccacctcctggagtatttctgtgaccaagagctgcagcaccgggtggagtccttggca gcctttgcagagtgttatgtggacaagatgcagggcaaccagcggggtcgctacggcctc ctcatgaaagccttcaccatgagcgcggccgagaccgcaaggcgcacccgagagttccgt tctccaccccaggagcagatcaacatgctattgcacttcaaaaatggcgcagatgaggaa gagtgccctctccctgaagagatccgacaggatttagtcaacttccaccaagacctgctg gcacattgtggaatccagctggagggagaggaggaggagcccgaggaggagagcactctg ggaagccgcctcatgagcttgttggaaaaagtaaagctggtgaagaagacagaggagaag cctgaggaggaggcggcacctgaggagcacaagcctcagtccttgcaggagctggtgtcc cacacagtggtgcgctgggcccaggaggacttcgttcagagcccggagctggtccgtgcc atgttcagcctcctgcaccggcagtacgacgggctcggagagctgctgcgtgccctgccc cgggcctacacaatctctctgtcctcggtggaggataccatgagcctgctggagtgcctg ggccagatccgctcactgctcattgtgcagatgggtccccaggaggagaaccttatgatc cagagcattgggaacatcatgaacaacaaagtcttctaccaacacccaaacctgatgaga gcgctgggtatgcatgaaacagtcatggaggttatggtgaacgtccttgggggcggcgag tcaaaggagatccgcttccccaagatggtgacaagctgctgccgcttcctctgctacttc tgccgaatcagccggcagaaccagcgctccatgtttgaccacctgagctacctgctggag aacagcggcattggcctgggcatgcagggctccacacccttggatgtagctgctgcttct gtcattgacaacaatgagctagccttggcattacaagagcaagacttggaaaaggttgtg tcatacctggcagggtgtggcttacaaagctgccccatgctcctggccaaaggctatcct gacatcggatggaatccctgtgggggcgaacgctaccttgacttcctgcgctttgccgtc tttgtcaacggtgagagcgtggaagagaatgctaacgtggtcgtgcggctgttgatccgc aagcccgagtgctttggacctgccctgcggggtgagggtggctcagggctgttggctgcc atcgaagaggccatccgaatctctgaggatcccgcacgggatgggccgggtgtccgcagg gaccggcgacgtgagcactttggtgaggagccccctgaagaaaaccgggtacacctggga catgccatcatgtccttctatgctgccttgattgacctgctaggacgctgtgcacctgag acgcatctgattcaagccggtaagggtgaggccctgaggatccgtgccatccttcggtcc ctcgtgcccttggatgacctcgtgggcatcatcagcctcccactgcagatccccaccctg ggcaaagatggcgccctggttcagccaaagatgtctgcatccttcgtgcctgaccacaag gcatccatggtgcttttcctggaccgagtgtatggcattgagaaccaggacttcttgctg catgtgctggatgtggggttccttcctgacatgagggcggctgcttcactggacacggct actttcagcaccacggagatggcgctggcactgaaccgctacctctgtctggctgtgctg ccgctcatcaccaagtgcgcgccactctttgcgggcaccgagcaccgcgccatcatggtg gactccatgctgcacacagtgtacaggctgtcgcggggccgctcgctcaccaaagcacag cgcgatgtcatcgaggactgcctcatggcgctgtgcaggtatatccgaccgtccatgctg cagcacctgcttcgacgcctggtgttcgatgtgcccatcctcaatgagttcgccaagatg ccactcaagctccttaccaaccactatgagcgctgctggaagtactactgcctccccaca ggctgggccaacttcggggtcacctctgaggaagagctgcacctcacacgcaagctcttc tggggcatctttgattctctggcgcataagaaatacgaccaggagctttaccgaatagcc atgccttgcctgtgtgccatcgcgggcgcactgccccctgactacgtggacgcctcatac tcatccaagacggagaaaaaagccacagtggacgctgaaggcaactttgatccccggcct gtggagaccctcaacgtcatcatccccgagaagctggactccttcattaacaagttcgca gagtacactcatgagaagtgggccttcgacaagattcagaacaattggtcctatggtgag aacattgatgaagaattgaagacccaccccatgctgagaccctacaagaccttctcagag aaggacaaagagatttaccgttggcccatcaaggagtctttgaaggccatgattgcctgg gaatggacagtagagaaggccagggaaggcgaggaggagaagacggaaaagaaaaaaaca agaaagatatcccaaaccgcccagacatatgacccccgagaaggctataatccccagcca ccagacctcagcgtggttaccttgtcccgggagctgcaggccatggccgaacaactggca gaaaattaccacaacacttgggggcgaaagaagaagcaagagctggaggctaaaggaggt gggtctcatcctctactggttccctacgacacgctcacggccaaggagaaggcacgggat cgagagaaggcccaggagctgctgaagtttctgcagatgaatggctatgctgtcaccagg ggtcttaaggacatggaactggacacatcctccattgagaagcgatttgccttcggcttc ctgcagcagctgcttcgctggatggacatctcccaggagttcatcgcccacctggaggct gtggttagcagtggacgggtggagaaatccccacatgaacaggagattaaattctttgct aagattctgctgcctttgatcaatcaatacttcaccaaccactgtctctacttcctatcc acaccagccaaagtgctgggcagtggtggccacgcctccaacaaggagaaggaaatgatc accagcctcttctgtaaacttgctgcccttgttcgccaccgagtctccctcttcgggacg gatgccccagctgtggtcaactgtcttcatatattggcacgctctctagatgccagaacg gtgatgaaatcgggccctgagatcgtaaaggcgggtctgcgctccttcttcgagagtgcc tccgaggacattgagaagatggtggagaacctgcggctaggaaaggtgtcgcaggcgcgc acgcaggtgaagggtgtgggccagaacctcacctacaccacggtggctctgctgcccgtc ctcaccaccctcttccagcacatcgcccagcaccagttcggagacgatgtcatcctggat gacgtacaagtgtcttgctaccgaacgctctgcagtatctactctctgggaaccaccagg aacccctacgtggaaaagctgcggccagctctcggggaatgcctggcccgcctggctgca gccatgccagtggcattcctggagcctgagctgaatgaatacaacgcctgctctgtctac accaccaagtctcctcgagagcgggccatcctggggcttcccaacagcgtggaggagatg tgtcctgacatcccagtgctagaaaggctcatggcagaaatcggggggctggccgagtcc ggagcacgctacacagagatgccgcatgtcatcgagattaccttgcctatgctgtgcagc tacctgccccgctggtgggagcgagggcctgaggcgcccccaccagccctgcctgcgggc gccccgccaccctgtacagcggtcacctccgaccacctcaattccctcctggggaacatc ctccgaatcatcgtgaacaacctgggcatcgatgaggcctcgtggatgaagcggctggcc gtgtttgcccagcccattgtgagccgtgccaggccagagctcctacgctcccacttcatc cctaccatcgggcgattgcgtaagcgggcagggaaggtggtggctgaggaggagcagctg cgcctggaggccaaagcagaagctgaggagggtgagctcctggtccgggatgagttctcc gtgctctgccgcgacctgtatgccctctacccactactcatccgctacgtagacaacaac agggcacactggctgacagagcccaaccccaatgcggaggagctgttcaggatggtggga gaaatcttcatctattggtccaagtcccacaactttaagcgtgaagaacagaacttcgtg gtccagaatgaaatcaacaacatgtcctttttgacagctgacaacaagagcaaaatggcc aagtcaggtggctcagatcaggaacgcaccaagaagaagcgccggggggaccgctactct gtgcagacatctttgatcgtggccacactcaagaagatgttgccgatcggactaaacatg tgtgctcccaccgaccaggacctcattgtgctggccaaagcccgctatgccctgaaagat acagatgaggaggtccgtgaattccttcaaaacaaccttaaccttcagggaaaggtggaa ggctcaccatctcttcgctggcaaatggcactgtaccgcggcgtcccaggccgcgaggaa gatgcggatgatcccgagaaaatcgtgcgcagagtccaggaagtgtcggcagtgctctat cacctggaccagacggagcatccttacaagtccaagaaggcggtgtggcataaacttctg tccaagcagcgccggagggctgtggtggcctgtttccgcatgacgcccctgtacaacttg cccacgcaccgagcgtgtaacatgttcttggagagctacaaagcctcctggatcctgact gaggaccacagtttcgaggaccgcatgatagatgacctatcgaaagctggagagcaggaa gaagaggaggaagaggtggaggaaaagaagccagacccactacaccagttggtcctacac ttcagccgcacagctctaactgaaaagagcaaactggacgaggactacctatacatggct tatgctgacatcatggcaaagagctgccacctggaggagggcggggaaaatggcgaagaa ggaggtgaagaagaggaagtggaggtgtcctttgaggagaaggagatggagaagcagagg ctcctgtaccagcagtcgaggctgcacaaccggggtgccgctgagatggtactgcagatg atcagtgcctgcaaaggagagacgggtgccatggtgtcttccaccctgaagctgggtatc tccatccttaacggagggaacgctgaagtgcagcagaaaatgctggattacctgaaggac aagaaggaagtgggcttcttccagagtatccaggcgctgatgcaaacgtgcagcgtcctg gacctcaatgccttcgagaggcagaacaaggcagaggggctgggcatggtgaacgaggac ggaactgtcatcaatcgccaaaacggagagaaagtcatggcggatgacgagttcacacag gacctgttccgcttcctgcagctgctctgcgaggggcacaacaatgatttccaaaactac ctacggacacagactgggaacacgaccaccatcaatatcatcatctgcacagtggactac ctcctgcggctgcaggaatccatcagtgacttctactggtattactcgggcaaggatgtc atcgaggaacagggaaagagaaacttctccaaagccatgtcggtagctaaacaagtgttc aacagcctcaccgagtacatccagggaccctgtaccggaaaccagcagagtctggcgcac agtcgcctctgggatgccgtggtgggcttcctgcacgtgttcgcgcacatgatgatgaag ctggctcaggactccagccagatagagctactgaaggagctgctggacctacagaaggac atggtggtgatgctgttgtccctcctggaaggaaacgtggtgaacggtatgatcgcgcgg cagatggtggacatgctcgtggaatcttcgtccaacgtggagatgattctcaagttcttc gacatgtttctgaaactcaaggacatcgtaggctctgaggccttccaggactacgtcaca gacccccgtggcctcatctccaagaaggacttccagaaggccatggacagccagaagcag ttcactggtccagagatccagttcctgctctcgtgttccgaagcagatgagaatgagatg atcaactgcgaagagtttgcgaaccgcttccaggaaccagcgcgggacattggcttcaat gtggcggtgctgcttaccaacctgtcagagcatgtgccccacgacccgcgcctgcgcaac ttcctggagctggctgagagcatcctggagtacttccggccttacctgggccgcatcgaa atcatgggcgcatcgcgtcgcatagaacggatctattttgagatctcagagaccaaccgt gcccagtgggagatgccccaggtgaaggagtccaagcgccagttcatcttcgacgtggtg aacgagggcggcgagtcggagaagatggagatgttcgtgagtttctgcgaggacacgatc ttcgagatgcagatcgccgctcagatctcggagcctgagggcgagccggaggaggacgag gacgagggcgccgaggaggctgaggagggcgcggcgggttccgacgggtcgggctctgca gcggccgcgggcgtgtgggtgtggctggcagcgagtgcgggccgaacgctgcggggtctg agctaccggagcctgcggcgacgcgtgcggaggctgcggcggctgacggcgcgggaggct gccacggcggtggccgcgctgctctgggcgctggtgacccgcgcggggggtgcgggcgcg ggcgcggcagccggggcgctgcggctgctctggggctcgctgttcggtggtgggctggta gacagcgccaagaaagtgacagtgaccgagctcctggcaggcatgccggaccccaccggc gacgaggtgcacggccagcagccgagcggcgctggcagcgatgcagagggcgagggtgag ggtgaaggcgaaggcgatgctgccgacggcgccggagatgaagaggctgcagcggaccag gctggcacgggaggtgccgacggtgcggtggccgtggccgatgggagtcccttccggcca gaaggcgccggtggtctcggagatatgggtgacacgacgccagtggagccccccacgcca gaaggctcgcccatcctcaagaggaagctgggggtggatggagaagaggaggagccgccc ccggagccagagccagagccggagcccgaaccggagaaagctgatacagagaatggagag aaggaagtccccgagccacctccagagccccccaagaagacaccacctccaccccctcca aagaaagagggagccggaggagcaggcctggaagagctctggggcgaactggaagtacag agagtaaagtttttgaactacttgtcgaggaatttctacacattgcggttcctggccctc ttcctagcatttgccatcaacttcatcttactgttttataaggtctcagactctccacca ggggaggatgacatagaaggttccggtgccggggacatgtcaggggcagggtctggtgat ggctctggctggggctccagggccggcgaggaggtagagggcgatgaagatgagaacatg gtgtactacttcctggaggagagcaccggctacatggaacctgccctgaggtgcttgagc ctgctgcacacgctggtggcctttctctgcatcattggctacaactgtctcaaggtgccc cttgtcatcttcaagcgggagaaggagctggcccggaagctggagtttgatggtctctac attacagagcagccagaggatgacgacgtgaagggacagtgggaccgcctggtgctcaac acgccgtctttccctagcaactactgggacaagtttgtcaagcggaaggttctggacaaa cacggggacatctttgggcgggagcggattgcggagctgctgggcatggatctggcctct ctggagatcacagcccacaacgaacgcaaacctgaccctccaccgggcctgctgacatgg atcatgtctatcgatgtcaaataccagatctggaagtttggagtcatcttcacagacaat tctttcctgtatctgggctggtacatggtgatgtccctcctggggcactacaataacttc ttctttgctgcccacctcctggacatcgccatgggagtcaagacgctccgcaccatcctt tcatctgtcactcacaatggaaaacagctcgtgatgaccgtagggctcctggccgtagtg gtctacttgtatacagtggtggccttcaacttcttccgcaaattctacaacaagagcgaa gatgaggacgagcctgacatgaagtgtgatgacatgatgacgtgctacctgttccacatg tatgtgggcgtccgggccggtggagggatcggggacgagatcgaggacccggccggtgat gaatatgaactttaccgggtcgtcttcgacatcacctttttcttcttcgttatcgtcatc ctgctggccatcattcagggtctgattatcgatgcttttggggagctccgagaccaacaa gagcaagtgaaggaagacatggagaccaagtgcttcatctgtggaataggcagtgactac ttcgacacaaccccacatgggtttgagacccacactctagaagagcacaacctagccaat tacatgtttttcctgatgtatttgataaataaggatgagacagagcacactggtcaggag tcgtatgtctggaagatgtaccaggaaaggtgctgggatttctttcctgctggagactgt ttccgcaagcagtatgaggaccagcttagctga

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