| Entry |
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| Symbol |
TH
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| Name |
(RefSeq) tyrosine 3-monooxygenase isoform X1
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| KO |
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| Organism |
mcf Macaca fascicularis (crab-eating macaque)
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| Pathway |
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| Module |
| mcf_M00042 | Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline |
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| Brite |
KEGG Orthology (KO) [BR:mcf00001]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
102134074 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
102134074 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
102134074 (TH)
09156 Nervous system
04728 Dopaminergic synapse
102134074 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
102134074 (TH)
09165 Substance dependence
05030 Cocaine addiction
102134074 (TH)
05031 Amphetamine addiction
102134074 (TH)
05034 Alcoholism
102134074 (TH)
Enzymes [BR:mcf01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
102134074 (TH)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
14:complement(join(2081870..2082029,2082877..2083010,2083313..2083408,2083646..2083702,2084125..2084194,2084278..2084413,2084546..2084691,2085089..2085139,2085521..2085588,2085747..2085835,2086148..2086322,2087288..2087509,2089268..2089369))
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| AA seq |
501 aa
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQSPRFVGRRQSLIEDARKEREAAVAAA
AAAAPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIQHLETR
PAQRLRVGGPHLEYFVRLEVPRGDLAALLSGVRQVSEDVRSPAEPKVPWFPRKVSELDKC
HHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY
TTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSA
RDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASL
GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA
AAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVR
RSLEGVQDELDTLAHALSAIG |
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| NT seq |
1506 nt +upstreamnt +downstreamnt
atgcccacccccgacgccaccacaccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatggtaagaggacagtccccgcggttcgttggg
cgacggcagagcctcatcgaggacgcccgcaaggagcgggaggcagcggtggcagcagca
gctgctgcagccccctcggagcccggggaccccctggaggccgtggcctttgaggaaaag
gaggggaaggccgtgctaaacctgctcttctccccgagggccaccaagccctcagcgctg
tcccgagctgtgaaggtatttgagacgtttgaagccaaaatccaacacctagagacccgg
cctgcccagaggctgcgagtcgggggcccccacctggagtactttgtgcgcctcgaggtg
ccccgaggggacctggccgccctgctcagtggtgtgcgccaggtgtcagaggacgtgcgc
agccccgcggagcccaaggtcccctggttcccaagaaaagtgtcagagctggacaagtgt
catcatctggtcaccaagtttgaccctgacctggacttggaccacccgggcttctcggac
caggtgtaccgccagcgcaggaagctgattgctgagatcgccttccagtacaggcacggt
gacccgattccccgtgtggagtacactgccgaggagattgccacctggaaggaggtctac
accacgctgaagggcctctacgccacgcacgcctgcggggagcacctggaggcctttgct
ctgctggagcgcttcagcggctaccgggaagacaacatcccccagctggaggatgtttcc
cgcttcctgaaggagcgcacgggcttccagctgcggcctgtggctggcctgctgtccgcc
cgggacttcctggccagcctggccttccgcgtgttccagtgcacccagtatatccggcac
gcgtcctcgcccatgcactcccctgagccggactgctgccacgagctgctggggcacgtg
cccatgctggccgaccgcaccttcgcgcagttctcccaggacatcggcctggcatccctg
ggggcctcggatgaggaaattgagaagttgtccacgctgtactggtttaccgtggagttt
gggctgtgcaaacagaacggggaggtgaaggcctatggcgccgggctgctgtcctcctat
ggggagctactgcactgcctgtctgaggagcccgagattcgagccttcgaccctgaagca
gcggctgtgcagccctaccaagaccagacgtaccagtcagtctactttgtgtctgagagc
ttcagcgatgccaaggacaagctcaggagctatgcgtcacgcatccagcgccccttctcc
gtgaagttcgacccgtacaccctggccatcgacgtgctggacagcccccaggccgtgcgg
cgctccctggagggtgtccaggatgagctggacaccctggcccatgcgctgagtgccatt
ggctag |
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